lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9788
Symbol	MTSS1
Synonymous	MIM\|MIMA\|MIMB
Full name	metastasis suppressor 1
Gene description	metastasis suppressor YGL-1\|metastasis suppressor protein 1\|missing in metastasis protein
Cytoband	8p22
Gene type	protein-coding
Synonymous	MIM:608486; HGNC:HGNC:20443; Ensembl:ENSG00000170873; HPRD:12243; Vega:OTTHUMG00000048189

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1916A>G; p.E639G; 8:124553344-124553344	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2183G>A; p.G728E; 8:124553077-124553077	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1141C>T; p.R381W; 8:124557770-124557770	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1093G>A; p.G365S; 8:124557818-124557818	skin	malignant_melanoma	Substitution - Missense
c.1520C>T; p.T507I; 8:124555789-124555789	breast	carcinoma	Substitution - Missense
c.565A>G; p.I189V; 8:124568432-124568432	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.565A>G; p.I189V; 8:124568432-124568432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1983C>A; p.P661P; 8:124553277-124553277	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.565A>G; p.I189V; 8:124568432-124568432	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1649G>C; p.R550T; 8:124553611-124553611	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.99C>T; p.F33F; 8:124704165-124704165	skin	malignant_melanoma	Substitution - coding silent
c.459_460insA; p.G154fs*4; 8:124585087-124585088	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.618+2T>C; p.?; 8:124568377-124568377	lung	carcinoma; adenocarcinoma	Unknown
c.1283G>A; p.R428H; 8:124556353-124556353	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1733G>A; p.G578E; 8:124553527-124553527	skin	malignant_melanoma	Substitution - Missense
c.1798C>T; p.R600C; 8:124553462-124553462	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1798C>T; p.R600C; 8:124553462-124553462	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1798C>T; p.R600C; 8:124553462-124553462	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918C>T; p.R640W; 8:124553342-124553342	breast	carcinoma	Substitution - Missense
c.1400C>A; p.T467N; 8:124556236-124556236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918C>T; p.R640W; 8:124553342-124553342	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1638C>A; p.S546S; 8:124553622-124553622	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.240C>T; p.T80T; 8:124591204-124591204	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.168C>T; p.D56D; 8:124699566-124699566	breast	carcinoma	Substitution - coding silent
c.2129G>A; p.G710D; 8:124553131-124553131	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2217G>A; p.V739V; 8:124553043-124553043	parathyroid	carcinoma	Substitution - coding silent
c.294C>A; p.S98R; 8:124589711-124589711	breast	carcinoma	Substitution - Missense
c.40G>T; p.G14C; 8:124727916-124727916	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.759C>T; p.S253S; 8:124565727-124565727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.873C>G; p.H291Q; 8:124562944-124562944	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1015C>T; p.P339S; 8:124562802-124562802	skin	malignant_melanoma	Substitution - Missense
c.1804G>A; p.G602R; 8:124553456-124553456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1804G>A; p.G602R; 8:124553456-124553456	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.773C>T; p.T258M; 8:124565713-124565713	prostate	carcinoma	Substitution - Missense
c.773C>T; p.T258M; 8:124565713-124565713	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2173A>G; p.T725A; 8:124553087-124553087	thyroid	other; neoplasm	Substitution - Missense
c.1332C>T; p.T444T; 8:124556304-124556304	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1769G>A; p.R590Q; 8:124553491-124553491	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1769G>A; p.R590Q; 8:124553491-124553491	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.1867G>A; p.V623I; 8:124553393-124553393	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.2132A>G; p.Q711R; 8:124553128-124553128	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.984T>C; p.D328D; 8:124562833-124562833	thyroid	other; neoplasm	Substitution - coding silent
c.899G>A; p.R300H; 8:124562918-124562918	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.423C>A; p.S141S; 8:124585124-124585124	skin	malignant_melanoma	Substitution - coding silent
c.745G>A; p.G249S; 8:124565741-124565741	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1883G>T; p.G628V; 8:124553377-124553377	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2196G>A; p.L732L; 8:124553064-124553064	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.935T>C; p.V312A; 8:124562882-124562882	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1842C>T; p.P614P; 8:124553418-124553418	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1967G>T; p.G656V; 8:124553293-124553293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1998C>T; p.S666S; 8:124553262-124553262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.401G>A; p.R134H; 8:124585146-124585146	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.212G>T; p.G71V; 8:124591232-124591232	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1187T>C; p.I396T; 8:124557724-124557724	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.266T>C; p.I89T; 8:124591178-124591178	liver	carcinoma	Substitution - Missense
c.2215G>A; p.V739M; 8:124553045-124553045	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>A; p.G349R; 8:124557866-124557866	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1805G>A; p.G602E; 8:124553455-124553455	skin	malignant_melanoma	Substitution - Missense
c.1017G>A; p.P339P; 8:124562800-124562800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1906G>A; p.G636R; 8:124553354-124553354	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1718T>C; p.L573P; 8:124553542-124553542	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.114A>G; p.G38G; 8:124704150-124704150	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.834_835delCA; p.N278fs*6; 8:124562982-124562983	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.216C>A; p.T72T; 8:124591228-124591228	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.938G>T; p.R313M; 8:124562879-124562879	NS	malignant_melanoma	Substitution - Missense
c.1293G>T; p.E431D; 8:124556343-124556343	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1153G>A; p.V385I; 8:124557758-124557758	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.938G>T; p.R313M; 8:124562879-124562879	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1377G>A; p.R459R; 8:124556259-124556259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1915G>A; p.E639K; 8:124553345-124553345	skin	malignant_melanoma	Substitution - Missense
c.400C>T; p.R134C; 8:124585147-124585147	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1972A>G; p.T658A; 8:124553288-124553288	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1959C>T; p.G653G; 8:124553301-124553301	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1959C>T; p.G653G; 8:124553301-124553301	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2234C>T; p.T745M; 8:124553026-124553026	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2234C>T; p.T745M; 8:124553026-124553026	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203Q; 8:124568389-124568389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.608G>A; p.R203Q; 8:124568389-124568389	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.501A>C; p.Q167H; 8:124568496-124568496	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1537T>C; p.C513R; 8:124555772-124555772	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1828C>A; p.P610T; 8:124553432-124553432	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.957C>A; p.S319S; 8:124562860-124562860	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.580C>T; p.R194*; 8:124568417-124568417	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2118T>G; p.T706T; 8:124553142-124553142	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.290C>T; p.S97L; 8:124591154-124591154	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1339G>A; p.G447S; 8:124556297-124556297	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2114C>T; p.A705V; 8:124553146-124553146	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.426G>A; p.S142S; 8:124585121-124585121	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2115C>A; p.A705A; 8:124553145-124553145	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1394C>T; p.A465V; 8:124556242-124556242	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2168G>A; p.R723K; 8:124553092-124553092	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.345G>A; p.W115*; 8:124589660-124589660	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.94G>T; p.D32Y; 8:124704170-124704170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.417G>T; p.K139N; 8:124585130-124585130	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1206G>A; p.P402P; 8:124557705-124557705	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2000G>A; p.G667D; 8:124553260-124553260	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2000G>A; p.G667D; 8:124553260-124553260	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.716C>G; p.S239*; 8:124567081-124567081	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.276G>T; p.K92N; 8:124591168-124591168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.966A>T; p.S322S; 8:124562851-124562851	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2192T>G; p.M731R; 8:124553068-124553068	liver	carcinoma	Substitution - Missense
c.2192T>G; p.M731R; 8:124553068-124553068	liver	carcinoma	Substitution - Missense
c.1657G>A; p.D553N; 8:124553603-124553603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2192T>G; p.M731R; 8:124553068-124553068	liver	carcinoma	Substitution - Missense
c.2125C>A; p.P709T; 8:124553135-124553135	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2192T>G; p.M731R; 8:124553068-124553068	liver	carcinoma	Substitution - Missense
c.205C>T; p.R69C; 8:124699529-124699529	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.205C>T; p.R69C; 8:124699529-124699529	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.517T>C; p.Y173H; 8:124568480-124568480	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.517T>C; p.Y173H; 8:124568480-124568480	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2144G>A; p.S715N; 8:124553116-124553116	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1317G>T; p.G439G; 8:124556319-124556319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1169A>T; p.Y390F; 8:124557742-124557742	pancreas	carcinoma	Substitution - Missense
c.1352C>T; p.A451V; 8:124556284-124556284	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.801G>A; p.M267I; 8:124565685-124565685	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.379G>A; p.A127T; 8:124589626-124589626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1316G>A; p.G439E; 8:124556320-124556320	skin	malignant_melanoma	Substitution - Missense
c.1614T>A; p.D538E; 8:124553646-124553646	skin	malignant_melanoma	Substitution - Missense
c.151G>T; p.A51S; 8:124699583-124699583	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.41G>T; p.G14V; 8:124727915-124727915	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>T; p.E90*; 8:124591176-124591176	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1374A>T; p.P458P; 8:124556262-124556262	liver	carcinoma	Substitution - coding silent
c.1374A>T; p.P458P; 8:124556262-124556262	liver	carcinoma	Substitution - coding silent
c.2069T>A; p.I690N; 8:124553191-124553191	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.566T>C; p.I189T; 8:124568431-124568431	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1130G>A; p.R377H; 8:124557781-124557781	pancreas	carcinoma	Substitution - Missense
c.566T>C; p.I189T; 8:124568431-124568431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898C>T; p.R300C; 8:124562919-124562919	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.911C>G; p.S304C; 8:124562906-124562906	breast	carcinoma	Substitution - Missense
c.134G>A; p.R45Q; 8:124704130-124704130	skin	malignant_melanoma	Substitution - Missense
c.792C>T; p.S264S; 8:124565694-124565694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.792C>T; p.S264S; 8:124565694-124565694	breast	carcinoma	Substitution - coding silent
c.1676G>A; p.R559Q; 8:124553584-124553584	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.459delA; p.R155fs*34; 8:124585088-124585088	stomach	adenocarcinoma	Deletion - Frameshift
c.459delA; p.R155fs*34; 8:124585088-124585088	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.459delA; p.R155fs*34; 8:124585088-124585088	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.459delA; p.R155fs*34; 8:124585088-124585088	liver	carcinoma	Deletion - Frameshift
c.459delA; p.R155fs*34; 8:124585088-124585088	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1247G>T; p.G416V; 8:124556389-124556389	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1138C>T; p.P380S; 8:124557773-124557773	skin	malignant_melanoma	Substitution - Missense
c.875C>A; p.S292*; 8:124562942-124562942	ovary	other; neoplasm	Substitution - Nonsense
c.403C>G; p.Q135E; 8:124585144-124585144	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.819C>G; p.V273V; 8:124565667-124565667	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1741A>G; p.M581V; 8:124553519-124553519	liver	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation