lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9770
Symbol	RASSF2
Synonymous	CENP-34\|RASFADIN
Full name	Ras association (RalGDS/AF-6) domain family member 2
Gene description	Ras association (RalGDS/AF-6) domain family 2\|centromere protein 34\|ras association domain-containing protein 2
Cytoband	20p13
Gene type	protein-coding
Synonymous	MIM:609492; HGNC:HGNC:9883; Ensembl:ENSG00000101265; HPRD:15218; Vega:OTTHUMG00000031790

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.933G>A; p.M311I; 20:4784321-4784321	skin	malignant_melanoma	Substitution - Missense
c.241C>G; p.P81A; 20:4795861-4795861	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.580C>G; p.R194G; 20:4789655-4789655	skin	malignant_melanoma	Substitution - Missense
c.862C>G; p.Q288E; 20:4786280-4786280	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.154G>T; p.V52L; 20:4795948-4795948	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.579C>A; p.V193V; 20:4789656-4789656	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.692-1G>C; p.?; 20:4787755-4787755	breast	carcinoma	Unknown
c.227G>A; p.R76H; 20:4795875-4795875	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.576C>T; p.N192N; 20:4789659-4789659	liver	carcinoma	Substitution - coding silent
c.576C>T; p.N192N; 20:4789659-4789659	liver	carcinoma	Substitution - coding silent
c.519C>T; p.G173G; 20:4790469-4790469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.576C>T; p.N192N; 20:4789659-4789659	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.227G>A; p.R76H; 20:4795875-4795875	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.356A>G; p.D119G; 20:4792559-4792559	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.356A>G; p.D119G; 20:4792559-4792559	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.452G>A; p.R151H; 20:4790536-4790536	liver	carcinoma	Substitution - Missense
c.232C>T; p.R78*; 20:4795870-4795870	skin	malignant_melanoma	Substitution - Nonsense
c.232C>T; p.R78*; 20:4795870-4795870	pancreas	carcinoma	Substitution - Nonsense
c.232C>T; p.R78*; 20:4795870-4795870	pancreas	carcinoma	Substitution - Nonsense
c.452G>A; p.R151H; 20:4790536-4790536	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.R78*; 20:4795870-4795870	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.232C>T; p.R78*; 20:4795870-4795870	liver	carcinoma	Substitution - Nonsense
c.232C>T; p.R78*; 20:4795870-4795870	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.452G>A; p.R151H; 20:4790536-4790536	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.452G>A; p.R151H; 20:4790536-4790536	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>A; p.V225M; 20:4788235-4788235	urinary_tract; bladder	carcinoma	Substitution - Missense
c.673G>A; p.V225M; 20:4788235-4788235	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.78T>A; p.H26Q; 20:4798067-4798067	urinary_tract; bladder	carcinoma	Substitution - Missense
c.743_744AG>CA; p.Q248P; 20:4787702-4787703	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.635T>G; p.F212C; 20:4789600-4789600	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.684G>A; p.T228T; 20:4788224-4788224	skin	malignant_melanoma	Substitution - coding silent
c.424C>T; p.R142C; 20:4790564-4790564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.787G>A; p.D263N; 20:4787659-4787659	skin; neck	malignant_melanoma	Substitution - Missense
c.99C>T; p.Y33Y; 20:4798046-4798046	skin	malignant_melanoma	Substitution - coding silent
c.560A>T; p.Y187F; 20:4789675-4789675	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.277G>A; p.G93R; 20:4795825-4795825	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.560A>T; p.Y187F; 20:4789675-4789675	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.772T>C; p.F258L; 20:4787674-4787674	skin	malignant_melanoma	Substitution - Missense
c.237C>A; p.P79P; 20:4795865-4795865	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.938G>A; p.R313Q; 20:4784316-4784316	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.653C>A; p.A218E; 20:4788255-4788255	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.938G>A; p.R313Q; 20:4784316-4784316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.938G>A; p.R313Q; 20:4784316-4784316	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.672C>T; p.Y224Y; 20:4788236-4788236	thyroid	carcinoma	Substitution - coding silent
c.248C>T; p.S83F; 20:4795854-4795854	skin; mucosal	malignant_melanoma	Substitution - Missense
c.908G>A; p.R303H; 20:4786234-4786234	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>T; p.E318*; 20:4784302-4784302	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.176C>A; p.S59Y; 20:4795926-4795926	kidney	other; neoplasm	Substitution - Missense
c.811G>A; p.D271N; 20:4787635-4787635	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.604C>T; p.P202S; 20:4789631-4789631	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.136-1G>A; p.?; 20:4795967-4795967	skin; face	carcinoma; squamous_cell_carcinoma	Unknown
c.497G>A; p.R166H; 20:4790491-4790491	breast	carcinoma	Substitution - Missense
c.286G>A; p.G96R; 20:4795816-4795816	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.286G>A; p.G96R; 20:4795816-4795816	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.464T>C; p.V155A; 20:4790524-4790524	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.D239N; 20:4787731-4787731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.348G>A; p.P116P; 20:4792567-4792567	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.210G>T; p.M70I; 20:4795892-4795892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.916A>G; p.T306A; 20:4784338-4784338	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.187C>T; p.R63C; 20:4795915-4795915	thyroid	carcinoma	Substitution - Missense
c.136-4G>A; p.?; 20:4795970-4795970	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.937C>T; p.R313*; 20:4784317-4784317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.699G>A; p.Q233Q; 20:4787747-4787747	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.525C>G; p.F175L; 20:4790463-4790463	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.470C>T; p.T157M; 20:4790518-4790518	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.226C>T; p.R76C; 20:4795876-4795876	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.739C>T; p.L247F; 20:4787707-4787707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.398T>C; p.L133P; 20:4790590-4790590	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.R166C; 20:4790492-4790492	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.213G>A; p.Q71Q; 20:4795889-4795889	liver	carcinoma	Substitution - coding silent
c.213G>A; p.Q71Q; 20:4795889-4795889	liver	carcinoma	Substitution - coding silent
c.492C>G; p.I164M; 20:4790496-4790496	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.734G>A; p.R245Q; 20:4787712-4787712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>A; p.E75K; 20:4795879-4795879	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.131G>A; p.R44Q; 20:4798014-4798014	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.834C>T; p.F278F; 20:4786308-4786308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.516C>T; p.N172N; 20:4790472-4790472	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.834C>T; p.F278F; 20:4786308-4786308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.834C>T; p.F278F; 20:4786308-4786308	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.834C>T; p.F278F; 20:4786308-4786308	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.834C>T; p.F278F; 20:4786308-4786308	liver	carcinoma	Substitution - coding silent
c.144C>T; p.D48D; 20:4795958-4795958	breast	carcinoma	Substitution - coding silent
c.733C>T; p.R245*; 20:4787713-4787713	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.183C>A; p.G61G; 20:4795919-4795919	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.252C>T; p.S84S; 20:4795850-4795850	skin; arm	malignant_melanoma	Substitution - coding silent
c.317A>C; p.K106T; 20:4792598-4792598	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.862C>T; p.Q288*; 20:4786280-4786280	skin	malignant_melanoma	Substitution - Nonsense
c.239delC; p.P80fs*20; 20:4795863-4795863	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.810C>T; p.Y270Y; 20:4787636-4787636	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.222C>T; p.N74N; 20:4795880-4795880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.222C>T; p.N74N; 20:4795880-4795880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.156G>T; p.V52V; 20:4795946-4795946	ovary	other; neoplasm	Substitution - coding silent
c.107G>A; p.G36D; 20:4798038-4798038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.448C>T; p.R150C; 20:4790540-4790540	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.448C>T; p.R150C; 20:4790540-4790540	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.707delA; p.K236fs*7; 20:4787739-4787739	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.714C>T; p.T238T; 20:4787732-4787732	pancreas	carcinoma; adenocarcinoma	Substitution - coding silent
c.849T>C; p.L283L; 20:4786293-4786293	prostate	carcinoma	Substitution - coding silent
c.431G>A; p.R144H; 20:4790557-4790557	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.249C>T; p.S83S; 20:4795853-4795853	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.632A>C; p.K211T; 20:4789603-4789603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.518G>T; p.G173V; 20:4790470-4790470	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.207G>T; p.Q69H; 20:4795895-4795895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>T; p.D126Y; 20:4792539-4792539	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.693G>T; p.E231D; 20:4787753-4787753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.507C>T; p.F169F; 20:4790481-4790481	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.507C>T; p.F169F; 20:4790481-4790481	skin	malignant_melanoma	Substitution - coding silent
c.425G>A; p.R142H; 20:4790563-4790563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344C>T; p.P115L; 20:4792571-4792571	pancreas	carcinoma	Substitution - Missense
c.194C>A; p.P65H; 20:4795908-4795908	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.449G>A; p.R150H; 20:4790539-4790539	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.722C>G; p.P241R; 20:4787724-4787724	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.20C>T; p.T7M; 20:4801011-4801011	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.188G>A; p.R63H; 20:4795914-4795914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.188G>A; p.R63H; 20:4795914-4795914	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.455G>A; p.R152H; 20:4790533-4790533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.324G>T; p.Q108H; 20:4792591-4792591	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.581G>A; p.R194H; 20:4789654-4789654	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.538-3C>A; p.?; 20:4789700-4789700	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.351G>A; p.E117E; 20:4792564-4792564	breast	carcinoma	Substitution - coding silent
c.119A>T; p.Q40L; 20:4798026-4798026	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.581G>T; p.R194L; 20:4789654-4789654	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.692-1G>A; p.?; 20:4787755-4787755	skin	malignant_melanoma	Unknown
c.581G>T; p.R194L; 20:4789654-4789654	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation