lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9610
Symbol	RIN1
Synonymous	-
Full name	Ras and Rab interactor 1
Gene description	ras and Rab interactor 1\|ras inhibitor 1\|ras inhibitor JC99\|ras inhibitor RIN1\|ras interaction/interference protein 1
Cytoband	11q13.2
Gene type	protein-coding
Synonymous	MIM:605965; HGNC:HGNC:18749; Ensembl:ENSG00000174791; HPRD:05813; Vega:OTTHUMG00000167085

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1944A>G; p.P648P; 11:66332684-66332684	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1873C>T; p.Q625*; 11:66333260-66333260	skin	malignant_melanoma	Substitution - Nonsense
c.542G>A; p.G181D; 11:66335412-66335412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2151G>A; p.E717E; 11:66332477-66332477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2335C>T; p.R779W; 11:66332293-66332293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2146G>T; p.E716*; 11:66332482-66332482	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1511G>A; p.R504H; 11:66333999-66333999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.57C>T; p.S19S; 11:66336346-66336346	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.87-5C>T; p.?; 11:66336163-66336163	liver	carcinoma	Unknown
c.87-5C>T; p.?; 11:66336163-66336163	liver	carcinoma	Unknown
c.1751C>T; p.A584V; 11:66333382-66333382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1846C>T; p.R616C; 11:66333287-66333287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.443A>G; p.Y148C; 11:66335622-66335622	skin; acral	malignant_melanoma	Substitution - Missense
c.1611C>T; p.D537D; 11:66333639-66333639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1886G>A; p.R629Q; 11:66332742-66332742	urinary_tract; bladder	carcinoma	Substitution - Missense
c.82G>C; p.E28Q; 11:66336321-66336321	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2184G>A; p.G728G; 11:66332444-66332444	ovary	other; neoplasm	Substitution - coding silent
c.1210C>T; p.Q404*; 11:66334589-66334589	lung	carcinoma; undifferentiated_carcinoma	Substitution - Nonsense
c.2197T>C; p.C733R; 11:66332431-66332431	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1540C>T; p.R514W; 11:66333970-66333970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1540C>T; p.R514W; 11:66333970-66333970	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.761C>T; p.S254F; 11:66335038-66335038	skin	malignant_melanoma	Substitution - Missense
c.1645C>A; p.H549N; 11:66333605-66333605	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2336G>A; p.R779Q; 11:66332292-66332292	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2336G>A; p.R779Q; 11:66332292-66332292	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2082C>T; p.P694P; 11:66332546-66332546	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2255C>T; p.S752F; 11:66332373-66332373	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2097C>T; p.L699L; 11:66332531-66332531	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2242A>T; p.I748F; 11:66332386-66332386	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.155C>T; p.P52L; 11:66336090-66336090	breast	carcinoma	Substitution - Missense
c.32C>T; p.S11F; 11:66336371-66336371	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.610C>T; p.P204S; 11:66335189-66335189	skin	malignant_melanoma	Substitution - Missense
c.1148T>G; p.V383G; 11:66334651-66334651	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.87-6C>T; p.?; 11:66336164-66336164	liver	carcinoma	Unknown
c.87-6C>T; p.?; 11:66336164-66336164	liver	carcinoma	Unknown
c.745G>A; p.V249M; 11:66335054-66335054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.470_472delTCC; p.L157delL; 11:66335482-66335484	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.470_472delTCC; p.L157delL; 11:66335482-66335484	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.745G>A; p.V249M; 11:66335054-66335054	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2257G>C; p.E753Q; 11:66332371-66332371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2257G>C; p.E753Q; 11:66332371-66332371	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2347G>C; p.E783Q; 11:66332281-66332281	urinary_tract; bladder	carcinoma	Substitution - Missense
c.547+8C>T; p.?; 11:66335399-66335399	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2128C>T; p.Q710*; 11:66332500-66332500	skin	malignant_melanoma	Substitution - Nonsense
c.2104C>T; p.R702C; 11:66332524-66332524	skin	malignant_melanoma	Substitution - Missense
c.1823G>A; p.R608H; 11:66333310-66333310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.911G>A; p.S304N; 11:66334888-66334888	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.731G>A; p.S244N; 11:66335068-66335068	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.742C>T; p.R248C; 11:66335057-66335057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2143G>A; p.E715K; 11:66332485-66332485	skin	malignant_melanoma	Substitution - Missense
c.420C>T; p.D140D; 11:66335645-66335645	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.905G>A; p.G302D; 11:66334894-66334894	skin	malignant_melanoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653C>T; p.T218I; 11:66335146-66335146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.805G>A; p.V269M; 11:66334994-66334994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1955T>C; p.I652T; 11:66332673-66332673	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>G; p.P268R; 11:66334996-66334996	breast	carcinoma	Substitution - Missense
c.1761C>G; p.A587A; 11:66333372-66333372	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1116G>A; p.M372I; 11:66334683-66334683	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.348C>T; p.F116F; 11:66335796-66335796	skin	malignant_melanoma	Substitution - coding silent
c.1409G>A; p.R470H; 11:66334101-66334101	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2213A>G; p.D738G; 11:66332415-66332415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1409G>A; p.R470H; 11:66334101-66334101	liver	carcinoma	Substitution - Missense
c.769C>T; p.L257L; 11:66335030-66335030	NS	malignant_melanoma	Substitution - coding silent
c.769C>T; p.L257L; 11:66335030-66335030	NS	malignant_melanoma	Substitution - coding silent
c.1791C>T; p.T597T; 11:66333342-66333342	skin	malignant_melanoma	Substitution - coding silent
c.1091T>G; p.V364G; 11:66334708-66334708	central_nervous_system; brain	glioma; oligodendroglioma_Grade_II	Substitution - Missense
c.1612G>A; p.E538K; 11:66333638-66333638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1947A>G; p.E649E; 11:66332681-66332681	thyroid	other; neoplasm	Substitution - coding silent
c.776C>T; p.P259L; 11:66335023-66335023	skin	malignant_melanoma	Substitution - Missense
c.969G>A; p.E323E; 11:66334830-66334830	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.401C>G; p.S134W; 11:66335664-66335664	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1821G>T; p.R607R; 11:66333312-66333312	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2278C>A; p.Q760K; 11:66332350-66332350	thyroid	other; neoplasm	Substitution - Missense
c.1845G>A; p.Q615Q; 11:66333288-66333288	pancreas	carcinoma	Substitution - coding silent
c.626G>A; p.R209Q; 11:66335173-66335173	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.626G>A; p.R209Q; 11:66335173-66335173	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2098G>A; p.V700I; 11:66332530-66332530	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1024C>T; p.R342C; 11:66334775-66334775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1024C>T; p.R342C; 11:66334775-66334775	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1928C>T; p.T643I; 11:66332700-66332700	skin	malignant_melanoma	Substitution - Missense
c.1928C>T; p.T643I; 11:66332700-66332700	skin	malignant_melanoma	Substitution - Missense
c.1031G>A; p.R344Q; 11:66334768-66334768	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.266G>A; p.G89E; 11:66335979-66335979	liver	carcinoma	Substitution - Missense
c.1702C>T; p.P568S; 11:66333548-66333548	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.501C>T; p.H167H; 11:66335453-66335453	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.635A>G; p.Q212R; 11:66335164-66335164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.527C>T; p.A176V; 11:66335427-66335427	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1442G>T; p.G481V; 11:66334068-66334068	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.777A>C; p.P259P; 11:66335022-66335022	liver	carcinoma	Substitution - coding silent
c.2112G>A; p.A704A; 11:66332516-66332516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.73C>G; p.L25V; 11:66336330-66336330	breast	carcinoma	Substitution - Missense
c.1601C>T; p.A534V; 11:66333649-66333649	liver	carcinoma	Substitution - Missense
c.1601C>T; p.A534V; 11:66333649-66333649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1601C>T; p.A534V; 11:66333649-66333649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1601C>T; p.A534V; 11:66333649-66333649	liver	carcinoma	Substitution - Missense
c.331G>A; p.A111T; 11:66335813-66335813	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2058T>G; p.P686P; 11:66332570-66332570	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.538C>A; p.L180M; 11:66335416-66335416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1441G>A; p.G481R; 11:66334069-66334069	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.940_941insG; p.V314fs*107; 11:66334858-66334859	prostate	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2296G>T; p.G766C; 11:66332332-66332332	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1079C>T; p.P360L; 11:66334720-66334720	breast	carcinoma	Substitution - Missense
c.1971G>T; p.Q657H; 11:66332657-66332657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.368T>G; p.L123R; 11:66335776-66335776	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2261C>T; p.T754I; 11:66332367-66332367	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.583C>T; p.R195W; 11:66335216-66335216	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1258G>A; p.E420K; 11:66334541-66334541	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1531C>T; p.Q511*; 11:66333979-66333979	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1746C>A; p.L582L; 11:66333387-66333387	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2056C>T; p.P686S; 11:66332572-66332572	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2056C>T; p.P686S; 11:66332572-66332572	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2056C>T; p.P686S; 11:66332572-66332572	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.394G>C; p.E132Q; 11:66335671-66335671	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation