lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	959
Symbol	CD40LG
Synonymous	CD154\|CD40L\|HIGM1\|IGM\|IMD3\|T-BAM\|TNFSF5\|TRAP\|gp39\|hCD40L
Full name	CD40 ligand
Gene description	CD40 antigen ligand\|CD40-L\|T-B cell-activating molecule\|T-cell antigen Gp39\|TNF-related activation protein\|tumor necrosis factor (ligand) superfamily member 5
Cytoband	Xq26
Gene type	protein-coding
Synonymous	MIM:300386; HGNC:HGNC:11935; Ensembl:ENSG00000102245; HPRD:02311; Vega:OTTHUMG00000022512

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.48A>G; p.G16G; 23:136648296-136648296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.226G>T; p.E76*; 23:136650335-136650335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.316A>T; p.K106*; 23:136654400-136654400	ovary	other; neoplasm	Substitution - Nonsense
c.546_573del28; p.S185fs*2; 23:136659175-136659202	stomach	carcinoma; adenocarcinoma	Deletion - Frameshift
c.277delG; p.G93fs*3; 23:136650386-136650386	thyroid	carcinoma; medullary_carcinoma	Deletion - Frameshift
c.466G>A; p.E156K; 23:136659095-136659095	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.414_415insA; p.Q139fs*4; 23:136659043-136659044	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.677G>A; p.G226E; 23:136659306-136659306	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.368C>T; p.A123V; 23:136656377-136656377	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.335A>C; p.E112A; 23:136654419-136654419	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.465G>A; p.L155L; 23:136659094-136659094	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.224G>A; p.G75E; 23:136650333-136650333	skin	malignant_melanoma	Substitution - Missense
c.178C>A; p.H60N; 23:136650287-136650287	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.178C>A; p.H60N; 23:136650287-136650287	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.403A>G; p.T135A; 23:136656412-136656412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.655G>A; p.G219R; 23:136659284-136659284	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>A; p.V153I; 23:136659086-136659086	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.369G>A; p.A123A; 23:136656378-136656378	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.390C>T; p.A130A; 23:136656399-136656399	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.33A>G; p.R11R; 23:136648281-136648281	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.139C>T; p.H47Y; 23:136648387-136648387	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.346+2T>A; p.?; 23:136654432-136654432	lung	carcinoma; adenocarcinoma	Unknown
c.153C>T; p.D51D; 23:136648401-136648401	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.761C>A; p.T254K; 23:136659390-136659390	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.583C>G; p.L195V; 23:136659212-136659212	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.618C>A; p.L206L; 23:136659247-136659247	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.6C>T; p.I2I; 23:136648254-136648254	skin	malignant_melanoma	Substitution - coding silent
c.485C>A; p.T162N; 23:136659114-136659114	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.262A>G; p.K88E; 23:136650371-136650371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.7G>A; p.E3K; 23:136648255-136648255	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.148T>C; p.L50L; 23:136648396-136648396	thyroid	other; neoplasm	Substitution - coding silent
c.148T>C; p.L50L; 23:136648396-136648396	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.148T>C; p.L50L; 23:136648396-136648396	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.322G>T; p.E108*; 23:136654406-136654406	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.40G>A; p.A14T; 23:136648288-136648288	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.762G>T; p.T254T; 23:136659391-136659391	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.151G>C; p.D51H; 23:136648399-136648399	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102C>A; p.T34T; 23:136648350-136648350	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.782T>A; p.L261H; 23:136659411-136659411	prostate	adenoma	Substitution - Missense
c.160G>T; p.E54*; 23:136650269-136650269	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.414A>G; p.L138L; 23:136659043-136659043	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.370G>T; p.A124S; 23:136656379-136656379	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.170G>A; p.R57K; 23:136650279-136650279	breast	carcinoma	Substitution - Missense
c.642C>T; p.S214S; 23:136659271-136659271	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.32G>A; p.R11Q; 23:136648280-136648280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.32G>A; p.R11Q; 23:136648280-136648280	skin	malignant_melanoma	Substitution - Missense
c.53C>G; p.P18R; 23:136648301-136648301	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.170G>T; p.R57M; 23:136650279-136650279	skin	malignant_melanoma	Substitution - Missense
c.274G>A; p.E92K; 23:136650383-136650383	skin	malignant_melanoma	Substitution - Missense
c.340C>G; p.Q114E; 23:136654424-136654424	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>A; p.T105T; 23:136654399-136654399	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.287A>G; p.K96R; 23:136650396-136650396	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.749G>T; p.G250V; 23:136659378-136659378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>A; p.A215T; 23:136659272-136659272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.328A>T; p.S110C; 23:136654412-136654412	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.654C>T; p.C218C; 23:136659283-136659283	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.654C>T; p.C218C; 23:136659283-136659283	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>G; p.N150K; 23:136659079-136659079	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.542G>A; p.R181Q; 23:136659171-136659171	thyroid	carcinoma	Substitution - Missense
c.425delA; p.G144fs*5; 23:136659054-136659054	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.430G>A; p.G144R; 23:136659059-136659059	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.430G>A; p.G144R; 23:136659059-136659059	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.204G>A; p.T68T; 23:136650313-136650313	skin	malignant_melanoma	Substitution - coding silent
c.608G>T; p.R203I; 23:136659237-136659237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.707C>T; p.S236L; 23:136659336-136659336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.498A>C; p.Q166H; 23:136659127-136659127	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524T>C; p.V175A; 23:136659153-136659153	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.498A>C; p.Q166H; 23:136659127-136659127	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 23:136659356-136659356	skin	malignant_melanoma	Substitution - Missense
c.632C>A; p.T211N; 23:136659261-136659261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.646A>G; p.K216E; 23:136659275-136659275	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.31C>T; p.R11*; 23:136648279-136648279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.542G>T; p.R181L; 23:136659171-136659171	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.31C>T; p.R11*; 23:136648279-136648279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation