Cancer metastasis database

Annotation category 5

Gene information

Gene ID 958
Symbol

CD40

Synonymous

Bp50|CDW40|TNFRSF5|p50

Full name

CD40 molecule, TNF receptor superfamily member 5

Gene description

B cell surface antigen CD40|B cell-associated molecule|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|nerve growth factor receptor-related B-lymphocyte activation molecule|tumor necrosis factor receptor superfamily me

Cytoband

20q12-q13.2

Gene type

protein-coding

Synonymous

MIM:109535; HGNC:HGNC:11919; Ensembl:ENSG00000101017; HPRD:00178; Vega:OTTHUMG00000033053

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.421A>C; p.T141P; 20:46123143-46123143

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.560G>A; p.G187D; 20:46128138-46128138

 livercarcinomaSubstitution - Missense

c.368G>A; p.R123H; 20:46122721-46122721

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.774C>T; p.C258C; 20:46128980-46128980

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.294A>G; p.E98E; 20:46122647-46122647

 central_nervous_system; braingliomaSubstitution - coding silent

c.715C>T; p.P239S; 20:46128921-46128921

 skinmalignant_melanomaSubstitution - Missense

c.364C>A; p.H122N; 20:46122717-46122717

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.721G>A; p.D241N; 20:46128927-46128927

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.717C>T; p.P239P; 20:46128923-46128923

 pancreascarcinomaSubstitution - coding silent

c.312C>T; p.T104T; 20:46122665-46122665

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.69C>T; p.P23P; 20:46121837-46121837

 large_intestine; colonadenomaSubstitution - coding silent

c.780G>A; p.P260P; 20:46128986-46128986

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.475G>A; p.E159K; 20:46123197-46123197

 skinmalignant_melanomaSubstitution - Missense

c.475G>A; p.E159K; 20:46123197-46123197

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.483T>C; p.C161C; 20:46123205-46123205

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.483T>C; p.C161C; 20:46123205-46123205

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.647A>G; p.K216R; 20:46128330-46128330

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.653T>G; p.V218G; 20:46128336-46128336

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.477A>T; p.E159D; 20:46123199-46123199

 skinmalignant_melanomaSubstitution - Missense

c.401T>C; p.I134T; 20:46122754-46122754

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.106C>T; p.Q36*; 20:46121874-46121874

 breastcarcinomaSubstitution - Nonsense

c.268C>T; p.R90W; 20:46122621-46122621

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.796G>A; p.G266S; 20:46129002-46129002

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.612C>A; p.I204I; 20:46128190-46128190

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.444C>T; p.V148V; 20:46123166-46123166

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.652G>T; p.V218L; 20:46128335-46128335

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.128C>T; p.P43L; 20:46121896-46121896

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.336G>A; p.T112T; 20:46122689-46122689

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.504G>T; p.E168D; 20:46126646-46126646

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.327G>A; p.W109*; 20:46122680-46122680

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.363G>T; p.L121L; 20:46122716-46122716

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.131G>T; p.G44V; 20:46122233-46122233

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.304A>T; p.I102F; 20:46122657-46122657

 pancreascarcinomaSubstitution - Missense

c.210C>T; p.T70T; 20:46122312-46122312

 skinmalignant_melanomaSubstitution - coding silent

c.526C>T; p.Q176*; 20:46126668-46126668

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.273C>A; p.V91V; 20:46122626-46122626

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.769G>A; p.G257R; 20:46128975-46128975

 skinmalignant_melanomaSubstitution - Missense

c.769G>A; p.G257R; 20:46128975-46128975

 skinmalignant_melanomaSubstitution - Missense

c.249C>T; p.C83C; 20:46122351-46122351

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.249C>T; p.C83C; 20:46122351-46122351

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.676_677insC; p.H228fs*>51; 20:46128882-46128883

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.676_677insC; p.H228fs*>51; 20:46128882-46128883

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.603C>T; p.I201I; 20:46128181-46128181

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.8G>A; p.R3H; 20:46118351-46118351

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.797G>A; p.G266D; 20:46129003-46129003

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.797G>A; p.G266D; 20:46129003-46129003

 skinmalignant_melanomaSubstitution - Missense

c.36C>T; p.G12G; 20:46118379-46118379

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.279G>C; p.Q93H; 20:46122632-46122632

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.130+1G>A; p.?; 20:46121899-46121899

 skinmalignant_melanomaUnknown

c.14C>A; p.P5H; 20:46118357-46118357

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.316G>A; p.E106K; 20:46122669-46122669

 breastcarcinomaSubstitution - Missense

c.713T>C; p.F238S; 20:46128919-46128919

 skin; acralmalignant_melanomaSubstitution - Missense

c.570T>A; p.D190E; 20:46128148-46128148

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.49G>A; p.A17T; 20:46118392-46118392

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.607G>A; p.G203R; 20:46128185-46128185

 pancreascarcinomaSubstitution - Missense

c.244T>C; p.Y82H; 20:46122346-46122346

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.362T>C; p.L121P; 20:46122715-46122715

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.648A>G; p.K216K; 20:46128331-46128331

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.505A>C; p.T169P; 20:46126647-46126647

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense