lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9575
Symbol	CLOCK
Synonymous	KAT13D\|bHLHe8
Full name	clock circadian regulator
Gene description	circadian locomoter output cycles kaput protein\|circadian locomoter output cycles protein kaput\|class E basic helix-loop-helix protein 8\|clock homolog
Cytoband	4q12
Gene type	protein-coding
Synonymous	MIM:601851; HGNC:HGNC:2082; Ensembl:ENSG00000134852; HPRD:03508; Vega:OTTHUMG00000102141

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1319C>A; p.S440*; 4:55450120-55450120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.769T>G; p.L257V; 4:55458915-55458915	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1A>G; p.M1V; 4:55482785-55482785	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1764T>C; p.N588N; 4:55443825-55443825	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1709C>G; p.S570*; 4:55443880-55443880	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1539+2T>C; p.?; 4:55448777-55448777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.662C>A; p.S221Y; 4:55459159-55459159	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2157T>C; p.A719A; 4:55438486-55438486	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1789A>G; p.M597V; 4:55443800-55443800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>T; p.S336L; 4:55453800-55453800	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.1954C>G; p.Q652E; 4:55442583-55442583	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1460C>T; p.S487F; 4:55448858-55448858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>G; p.T88S; 4:55476048-55476048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>T; p.D17Y; 4:55479698-55479698	breast	carcinoma	Substitution - Missense
c.1459T>C; p.S487P; 4:55448859-55448859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1895C>T; p.S632L; 4:55443694-55443694	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2135A>C; p.K712T; 4:55438508-55438508	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367_368delTT; p.L123fs*13; 4:55470787-55470788	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.12C>T; p.T4T; 4:55482774-55482774	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.12C>T; p.T4T; 4:55482774-55482774	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1327_1328delAC; p.T443fs*28; 4:55450111-55450112	breast	carcinoma	Deletion - Frameshift
c.718A>G; p.T240A; 4:55458966-55458966	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.569A>G; p.Q190R; 4:55459252-55459252	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2261C>T; p.T754M; 4:55438382-55438382	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1833G>A; p.M611I; 4:55443756-55443756	liver	carcinoma	Substitution - Missense
c.2430G>C; p.Q810H; 4:55435526-55435526	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.175T>C; p.S59P; 4:55478896-55478896	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1408C>T; p.H470Y; 4:55449437-55449437	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1408C>T; p.H470Y; 4:55449437-55449437	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2342C>A; p.P781Q; 4:55438301-55438301	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.616G>A; p.E206K; 4:55459205-55459205	skin	malignant_melanoma	Substitution - Missense
c.1539+1G>T; p.?; 4:55448778-55448778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2460A>G; p.Q820Q; 4:55435496-55435496	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2355T>A; p.F785L; 4:55438288-55438288	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.875G>T; p.R292M; 4:55456218-55456218	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.355G>A; p.D119N; 4:55470800-55470800	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2482C>A; p.Q828K; 4:55435474-55435474	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1337C>G; p.S446*; 4:55450102-55450102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.645T>A; p.F215L; 4:55459176-55459176	liver	carcinoma	Substitution - Missense
c.395T>C; p.I132T; 4:55470760-55470760	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.2063A>G; p.Q688R; 4:55442474-55442474	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.416C>A; p.T139N; 4:55470739-55470739	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.416C>A; p.T139N; 4:55470739-55470739	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1926G>A; p.G642G; 4:55442611-55442611	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	NS	malignant_melanoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	liver	carcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2515G>A; p.D839N; 4:55435441-55435441	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2355T>G; p.F785L; 4:55438288-55438288	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1540-3C>A; p.?; 4:55444788-55444788	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368delT; p.L123fs*1; 4:55470787-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.66T>C; p.F22F; 4:55479681-55479681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1923T>G; p.S641R; 4:55442614-55442614	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.53A>C; p.D18A; 4:55479694-55479694	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.82G>A; p.E28K; 4:55479665-55479665	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.359G>T; p.G120V; 4:55470796-55470796	breast	carcinoma	Substitution - Missense
c.2017G>A; p.G673R; 4:55442520-55442520	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2017G>A; p.G673R; 4:55442520-55442520	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1283C>G; p.P428R; 4:55450156-55450156	ovary	other; neoplasm	Substitution - Missense
c.646A>T; p.I216L; 4:55459175-55459175	liver	carcinoma	Substitution - Missense
c.1297T>C; p.S433P; 4:55450142-55450142	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.475C>T; p.P159S; 4:55463769-55463769	skin	malignant_melanoma	Substitution - Missense
c.1024C>T; p.L342L; 4:55453783-55453783	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.188G>A; p.G63D; 4:55478883-55478883	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2375T>C; p.L792P; 4:55435581-55435581	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1945C>T; p.L649L; 4:55442592-55442592	breast	carcinoma	Substitution - coding silent
c.1662A>T; p.Q554H; 4:55444663-55444663	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1662A>T; p.Q554H; 4:55444663-55444663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1662A>T; p.Q554H; 4:55444663-55444663	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.815C>T; p.P272L; 4:55456278-55456278	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2134A>G; p.K712E; 4:55438509-55438509	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438T>G; p.F480V; 4:55449407-55449407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.566_567insA; p.N189fs*23; 4:55459254-55459255	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.265G>T; p.A89S; 4:55476046-55476046	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.392T>C; p.I131T; 4:55470763-55470763	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1291T>G; p.S431A; 4:55450148-55450148	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1397A>T; p.H466L; 4:55449448-55449448	liver	carcinoma	Substitution - Missense
c.1975G>A; p.A659T; 4:55442562-55442562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1397A>T; p.H466L; 4:55449448-55449448	liver	carcinoma	Substitution - Missense
c.1079A>G; p.H360R; 4:55453728-55453728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1234A>G; p.I412V; 4:55450205-55450205	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1588T>G; p.L530V; 4:55444737-55444737	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>G; p.F104L; 4:55475999-55475999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1367C>T; p.P456L; 4:55449478-55449478	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1714C>T; p.P572S; 4:55443875-55443875	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1304G>A; p.R435Q; 4:55450135-55450135	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.526G>C; p.E176Q; 4:55463718-55463718	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>A; p.D316N; 4:55455933-55455933	skin	malignant_melanoma	Substitution - Missense
c.859C>A; p.L287M; 4:55456234-55456234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1267A>G; p.R423G; 4:55450172-55450172	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1183C>T; p.L395F; 4:55453077-55453077	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.136C>T; p.R46C; 4:55478935-55478935	pancreas	carcinoma	Substitution - Missense
c.346G>T; p.E116*; 4:55475965-55475965	skin	malignant_melanoma	Substitution - Nonsense
c.1140A>C; p.E380D; 4:55453120-55453120	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.368_369insT; p.L123fs*14; 4:55470786-55470787	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.368_369insT; p.L123fs*14; 4:55470786-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.368_369insT; p.L123fs*14; 4:55470786-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.368_369insT; p.L123fs*14; 4:55470786-55470787	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.368_369insT; p.L123fs*14; 4:55470786-55470787	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.438+2T>C; p.?; 4:55470715-55470715	stomach	carcinoma; adenocarcinoma	Unknown
c.55A>G; p.S19G; 4:55479692-55479692	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1371G>A; p.T457T; 4:55449474-55449474	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1412A>G; p.E471G; 4:55449433-55449433	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.618G>A; p.E206E; 4:55459203-55459203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.514A>G; p.T172A; 4:55463730-55463730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1329G>A; p.T443T; 4:55450110-55450110	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2520_2521insGA; p.S841fs*>7; 4:55435435-55435436	lung	carcinoid-endocrine_tumour; atypical	Insertion - Frameshift
c.35C>T; p.S12L; 4:55482751-55482751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.352C>G; p.L118V; 4:55470803-55470803	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1706A>T; p.Q569L; 4:55443883-55443883	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.890T>C; p.I297T; 4:55455989-55455989	prostate	carcinoma	Substitution - Missense
c.1159C>T; p.R387*; 4:55453101-55453101	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.763G>A; p.V255I; 4:55458921-55458921	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.763G>A; p.V255I; 4:55458921-55458921	pancreas	carcinoma	Substitution - Missense
c.566A>G; p.N189S; 4:55459255-55459255	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2475A>G; p.Q825Q; 4:55435481-55435481	central_nervous_system; brain	glioma	Substitution - coding silent
c.94G>C; p.D32H; 4:55479653-55479653	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.I158I; 4:55463770-55463770	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.474C>T; p.I158I; 4:55463770-55463770	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1539+1_1539+2GT>TC; p.?; 4:55448777-55448778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2434A>G; p.T812A; 4:55435522-55435522	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2211A>G; p.A737A; 4:55438432-55438432	liver	carcinoma	Substitution - coding silent
c.244C>T; p.R82*; 4:55478827-55478827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation