lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	940
Symbol	CD28
Synonymous	Tp44
Full name	CD28 molecule
Gene description	CD28 antigen\|T-cell-specific surface glycoprotein CD28
Cytoband	2q33
Gene type	protein-coding
Synonymous	MIM:186760; HGNC:HGNC:1653; Ensembl:ENSG00000178562; HPRD:01727; Vega:OTTHUMG00000132878

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.383G>T; p.S128I; 2:203726963-203726963	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.97G>A; p.D33N; 2:203726677-203726677	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.97G>A; p.D33N; 2:203726677-203726677	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.439C>T; p.P147S; 2:203729677-203729677	skin	malignant_melanoma	Substitution - Missense
c.300G>T; p.Q100H; 2:203726880-203726880	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.655C>T; p.R219C; 2:203734904-203734904	breast	carcinoma	Substitution - Missense
c.210G>T; p.G70G; 2:203726790-203726790	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.624C>T; p.P208P; 2:203734873-203734873	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.629C>T; p.A210V; 2:203734878-203734878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.645C>T; p.F215F; 2:203734894-203734894	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.645C>T; p.F215F; 2:203734894-203734894	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.656G>A; p.R219H; 2:203734905-203734905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.R219H; 2:203734905-203734905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.R219H; 2:203734905-203734905	large_intestine; colon	carcinoma	Substitution - Missense
c.656G>A; p.R219H; 2:203734905-203734905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>T; p.V116F; 2:203726926-203726926	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.80C>T; p.P27L; 2:203726660-203726660	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.356C>A; p.P119H; 2:203726936-203726936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>A; p.S94*; 2:203726861-203726861	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.71A>G; p.K24R; 2:203726651-203726651	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.461G>T; p.W154L; 2:203729699-203729699	liver	carcinoma	Substitution - Missense
c.381G>A; p.K127K; 2:203726961-203726961	skin	malignant_melanoma	Substitution - coding silent
c.426A>G; p.P142P; 2:203729664-203729664	liver	carcinoma	Substitution - coding silent
c.607C>T; p.R203C; 2:203734856-203734856	breast	carcinoma	Substitution - Missense
c.449C>T; p.S150F; 2:203729687-203729687	urinary_tract; bladder	carcinoma	Substitution - Missense
c.74A>T; p.Q25L; 2:203726654-203726654	ovary	other; neoplasm	Substitution - Missense
c.473T>C; p.V158A; 2:203729711-203729711	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.361C>T; p.P121S; 2:203726941-203726941	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.146_147GG>AA; p.R49K; 2:203726726-203726727	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.595C>T; p.P199S; 2:203734844-203734844	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>A; p.D190E; 2:203734819-203734819	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.151T>G; p.F51V; 2:203726731-203726731	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Substitution - Missense
c.402T>C; p.H134H; 2:203726982-203726982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.609C>G; p.R203R; 2:203734858-203734858	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.370G>T; p.D124Y; 2:203726950-203726950	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.53-5C>T; p.?; 2:203726628-203726628	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.457T>C; p.F153L; 2:203729695-203729695	thyroid	carcinoma	Substitution - Missense
c.78G>A; p.S26S; 2:203726658-203726658	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.589C>T; p.R197C; 2:203734838-203734838	central_nervous_system; brain	glioma	Substitution - Missense
c.172G>A; p.G58R; 2:203726752-203726752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.589C>T; p.R197C; 2:203734838-203734838	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.589C>T; p.R197C; 2:203734838-203734838	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.275A>G; p.N92S; 2:203726855-203726855	urinary_tract; bladder	carcinoma	Substitution - Missense
c.122A>G; p.K41R; 2:203726702-203726702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.640G>A; p.D214N; 2:203734889-203734889	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.77C>G; p.S26W; 2:203726657-203726657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.155G>A; p.R52Q; 2:203726735-203726735	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.593G>A; p.R198H; 2:203734842-203734842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.593G>A; p.R198H; 2:203734842-203734842	prostate	carcinoma	Substitution - Missense
c.583A>G; p.T195A; 2:203734832-203734832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.417C>T; p.H139H; 2:203729655-203729655	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.417C>T; p.H139H; 2:203729655-203729655	skin	malignant_melanoma	Substitution - coding silent
c.240delA; p.T82fs*14; 2:203726820-203726820	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.646G>A; p.A216T; 2:203734895-203734895	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.539G>A; p.R180K; 2:203734788-203734788	skin	malignant_melanoma	Substitution - Missense
c.639C>T; p.R213R; 2:203734888-203734888	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.586delC; p.R197fs*>24; 2:203734835-203734835	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.604A>C; p.T202P; 2:203734853-203734853	breast	carcinoma	Substitution - Missense
c.171A>C; p.K57N; 2:203726751-203726751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.66G>A; p.L22L; 2:203726646-203726646	skin	malignant_melanoma	Substitution - coding silent
c.106G>T; p.V36F; 2:203726686-203726686	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation