lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9306
Symbol	SOCS6
Synonymous	CIS-4\|CIS4\|HSPC060\|SOCS-4\|SOCS-6\|SOCS4\|SSI4\|STAI4\|STATI4
Full name	suppressor of cytokine signaling 6
Gene description	STAT induced STAT inhibitor-4\|cytokine-inducible SH2 protein 4\|suppressor of cytokine signaling 4
Cytoband	18q22.2
Gene type	protein-coding
Synonymous	MIM:605118; HGNC:HGNC:16833; Ensembl:ENSG00000170677; HPRD:05491; Vega:OTTHUMG00000132816

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.346G>A; p.V116M; 18:70325014-70325014	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1160G>A; p.G387E; 18:70325828-70325828	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1082T>C; p.V361A; 18:70325750-70325750	liver	carcinoma	Substitution - Missense
c.595G>T; p.G199*; 18:70325263-70325263	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.408G>T; p.P136P; 18:70325076-70325076	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.126A>G; p.L42L; 18:70324794-70324794	ovary	other; neoplasm	Substitution - coding silent
c.840C>T; p.F280F; 18:70325508-70325508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.324A>T; p.S108S; 18:70324992-70324992	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1458A>G; p.R486R; 18:70326126-70326126	liver	carcinoma	Substitution - coding silent
c.1154A>G; p.Y385C; 18:70325822-70325822	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1370T>G; p.L457R; 18:70326038-70326038	stomach	adenocarcinoma	Substitution - Missense
c.904G>T; p.A302S; 18:70325572-70325572	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.D177N; 18:70325197-70325197	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1214C>A; p.S405Y; 18:70325882-70325882	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1427G>A; p.R476Q; 18:70326095-70326095	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.612C>A; p.H204Q; 18:70325280-70325280	ovary	other; neoplasm	Substitution - Missense
c.976T>G; p.F326V; 18:70325644-70325644	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.976T>G; p.F326V; 18:70325644-70325644	liver	carcinoma	Substitution - Missense
c.677C>T; p.P226L; 18:70325345-70325345	skin	malignant_melanoma	Substitution - Missense
c.274G>T; p.G92C; 18:70324942-70324942	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1004A>T; p.H335L; 18:70325672-70325672	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.778C>T; p.R260C; 18:70325446-70325446	breast	carcinoma	Substitution - Missense
c.778C>T; p.R260C; 18:70325446-70325446	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.92C>T; p.S31L; 18:70324760-70324760	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1201G>T; p.V401L; 18:70325869-70325869	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1513C>T; p.R505C; 18:70326181-70326181	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1357T>C; p.S453P; 18:70326025-70326025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.134G>T; p.S45I; 18:70324802-70324802	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.656A>G; p.D219G; 18:70325324-70325324	prostate	carcinoma	Substitution - Missense
c.964A>C; p.I322L; 18:70325632-70325632	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.166A>G; p.I56V; 18:70324834-70324834	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.166A>G; p.I56V; 18:70324834-70324834	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1079C>T; p.S360L; 18:70325747-70325747	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1079C>T; p.S360L; 18:70325747-70325747	urinary_tract; bladder	carcinoma	Substitution - Missense
c.500C>T; p.A167V; 18:70325168-70325168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.51A>T; p.K17N; 18:70324719-70324719	prostate	carcinoma	Substitution - Missense
c.573G>A; p.L191L; 18:70325241-70325241	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.317C>T; p.S106F; 18:70324985-70324985	skin	malignant_melanoma	Substitution - Missense
c.755C>T; p.A252V; 18:70325423-70325423	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432C>T; p.S144S; 18:70325100-70325100	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.592A>G; p.N198D; 18:70325260-70325260	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1473G>T; p.V491V; 18:70326141-70326141	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.900G>A; p.P300P; 18:70325568-70325568	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.419G>A; p.R140Q; 18:70325087-70325087	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.371C>T; p.S124F; 18:70325039-70325039	skin	malignant_melanoma	Substitution - Missense
c.1061T>A; p.V354D; 18:70325729-70325729	breast	carcinoma	Substitution - Missense
c.856A>G; p.N286D; 18:70325524-70325524	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.853G>A; p.V285M; 18:70325521-70325521	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.518A>C; p.K173T; 18:70325186-70325186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1241A>G; p.D414G; 18:70325909-70325909	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.198C>T; p.N66N; 18:70324866-70324866	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.254_255delAG; p.K86fs*28; 18:70324922-70324923	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.916G>T; p.D306Y; 18:70325584-70325584	NS	NS	Substitution - Missense
c.1214C>T; p.S405F; 18:70325882-70325882	skin	malignant_melanoma	Substitution - Missense
c.781G>A; p.A261T; 18:70325449-70325449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1214C>T; p.S405F; 18:70325882-70325882	breast	carcinoma	Substitution - Missense
c.1399A>G; p.N467D; 18:70326067-70326067	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.270G>T; p.K90N; 18:70324938-70324938	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.298G>A; p.D100N; 18:70324966-70324966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>T; p.R80W; 18:70324906-70324906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.817C>T; p.L273L; 18:70325485-70325485	skin	malignant_melanoma	Substitution - coding silent
c.231A>T; p.L77L; 18:70324899-70324899	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.876C>A; p.T292T; 18:70325544-70325544	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.763C>T; p.P255S; 18:70325431-70325431	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469G>A; p.A157T; 18:70325137-70325137	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1603T>C; p.Y535H; 18:70326271-70326271	ovary	other; neoplasm	Substitution - Missense
c.511G>A; p.V171I; 18:70325179-70325179	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1446T>C; p.T482T; 18:70326114-70326114	skin	malignant_melanoma	Substitution - coding silent
c.982G>T; p.G328*; 18:70325650-70325650	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.224G>T; p.G75V; 18:70324892-70324892	breast	carcinoma	Substitution - Missense
c.756G>A; p.A252A; 18:70325424-70325424	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1207G>C; p.D403H; 18:70325875-70325875	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1218T>C; p.F406F; 18:70325886-70325886	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1578G>A; p.M526I; 18:70326246-70326246	breast	carcinoma	Substitution - Missense
c.1453G>A; p.V485I; 18:70326121-70326121	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1304A>G; p.H435R; 18:70325972-70325972	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1526G>A; p.R509H; 18:70326194-70326194	central_nervous_system; brain	glioma	Substitution - Missense
c.1526G>A; p.R509H; 18:70326194-70326194	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.826G>A; p.A276T; 18:70325494-70325494	liver	carcinoma	Substitution - Missense
c.826G>A; p.A276T; 18:70325494-70325494	liver	carcinoma	Substitution - Missense
c.826G>A; p.A276T; 18:70325494-70325494	liver	carcinoma	Substitution - Missense
c.1022G>A; p.R341H; 18:70325690-70325690	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.181G>C; p.E61Q; 18:70324849-70324849	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.826G>A; p.A276T; 18:70325494-70325494	breast	carcinoma	Substitution - Missense
c.1358C>T; p.S453F; 18:70326026-70326026	breast	carcinoma	Substitution - Missense
c.1477C>T; p.R493W; 18:70326145-70326145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.115G>T; p.D39Y; 18:70324783-70324783	breast	carcinoma	Substitution - Missense
c.1315A>G; p.R439G; 18:70325983-70325983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1496C>T; p.S499L; 18:70326164-70326164	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1264T>C; p.F422L; 18:70325932-70325932	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.348G>A; p.V116V; 18:70325016-70325016	urinary_tract; bladder	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation