| Gene ID | 925 |
| Symbol | CD8A |
| Synonymous | CD8|Leu2|MAL|p32 |
| Full name | CD8a molecule |
| Gene description | CD8 antigen, alpha polypeptide (p32)|Leu2 T-lymphocyte antigen|OKT8 T-cell antigen|T cell co-receptor|T-cell antigen Leu2|T-cell surface glycoprotein CD8 alpha chain|T-lymphocyte differentiation antigen T8/Leu-2|T8 T-cell antigen |
| Cytoband | 2p12 |
| Gene type | protein-coding |
| Synonymous | MIM:186910; HGNC:HGNC:1706; Ensembl:ENSG00000153563; HPRD:01737; Vega:OTTHUMG00000130265 |
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.671C>A; p.S224*; 2:86785957-86785957 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; essential_thrombocythaemia | Substitution - Nonsense |
c.310G>T; p.D104Y; 2:86790421-86790421 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.306G>C; p.L102L; 2:86790425-86790425 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.486G>T; p.E162D; 2:86789668-86789668 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.187G>A; p.A63T; 2:86790544-86790544 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.187G>A; p.A63T; 2:86790544-86790544 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.251T>C; p.L84P; 2:86790480-86790480 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.109G>C; p.E37Q; 2:86790622-86790622 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.551A>G; p.Y184C; 2:86789397-86789397 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.211C>G; p.L71V; 2:86790520-86790520 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.603T>G; p.V201V; 2:86789345-86789345 |
skin | malignant_melanoma | Substitution - coding silent |
c.540C>T; p.A180A; 2:86789408-86789408 |
skin | malignant_melanoma | Substitution - coding silent |
c.145A>G; p.N49D; 2:86790586-86790586 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.111G>AG; p.T38fs*145; 2:86790620-86790620 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Complex - frameshift |
c.426G>A; p.A142A; 2:86789728-86789728 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.656G>A; p.R219Q; 2:86788530-86788530 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.521C>T; p.T174M; 2:86789427-86789427 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.479G>A; p.R160H; 2:86789675-86789675 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.192C>A; p.A64A; 2:86790539-86790539 |
thyroid | other; neoplasm | Substitution - coding silent |
c.192C>A; p.A64A; 2:86790539-86790539 |
thyroid | other; neoplasm | Substitution - coding silent |
c.316C>T; p.R106C; 2:86790415-86790415 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.109G>A; p.E37K; 2:86790622-86790622 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.118G>A; p.E40K; 2:86790613-86790613 |
skin | malignant_melanoma | Substitution - Missense |
c.98G>C; p.W33S; 2:86790633-86790633 |
prostate | carcinoma | Substitution - Missense |
c.118G>A; p.E40K; 2:86790613-86790613 |
skin | malignant_melanoma | Substitution - Missense |
c.111G>A; p.E37E; 2:86790620-86790620 |
skin | malignant_melanoma | Substitution - coding silent |
c.384C>T; p.F128F; 2:86790347-86790347 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.417G>A; p.T139T; 2:86789737-86789737 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.425C>T; p.A142V; 2:86789729-86789729 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.571G>A; p.G191R; 2:86789377-86789377 |
ovary | other; neoplasm | Substitution - Missense |
c.310G>A; p.D104N; 2:86790421-86790421 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.565T>C; p.L189L; 2:86789383-86789383 |
thyroid | other; neoplasm | Substitution - coding silent |
c.565T>C; p.L189L; 2:86789383-86789383 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.565T>C; p.L189L; 2:86789383-86789383 |
thyroid | other; neoplasm | Substitution - coding silent |
c.331G>T; p.G111C; 2:86790400-86790400 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.635G>A; p.R212K; 2:86788551-86788551 |
breast | carcinoma | Substitution - Missense |
c.561G>T; p.A187A; 2:86789387-86789387 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.237_238GG>AT; p.A80S; 2:86790493-86790494 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.347C>A; p.S116*; 2:86790384-86790384 |
liver | carcinoma | Substitution - Nonsense |
c.347C>A; p.S116*; 2:86790384-86790384 |
liver | carcinoma | Substitution - Nonsense |
c.637C>T; p.R213C; 2:86788549-86788549 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.695C>T; p.A232V; 2:86785933-86785933 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.695C>T; p.A232V; 2:86785933-86785933 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.150G>A; p.P50P; 2:86790581-86790581 |
autonomic_ganglia | neuroblastoma | Substitution - coding silent |
c.428C>T; p.P143L; 2:86789726-86789726 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.696G>A; p.A232A; 2:86785932-86785932 |
skin | malignant_melanoma | Substitution - coding silent |
c.60G>A; p.R20R; 2:86790671-86790671 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.384C>A; p.F128L; 2:86790347-86790347 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.384C>A; p.F128L; 2:86790347-86790347 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.110_111insA; p.T38fs*145; 2:86790620-86790621 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Insertion - Frameshift |
c.549C>G; p.I183M; 2:86789399-86789399 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.51C>T; p.H17H; 2:86790680-86790680 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.317G>A; p.R106H; 2:86790414-86790414 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.605T>A; p.I202N; 2:86789343-86789343 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia | Substitution - Missense |
c.279G>A; p.R93R; 2:86790452-86790452 |
thyroid | other; neoplasm | Substitution - coding silent |
c.674G>A; p.G225E; 2:86785954-86785954 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.276G>C; p.K92N; 2:86790455-86790455 |
breast | carcinoma | Substitution - Missense |
c.347C>T; p.S116L; 2:86790384-86790384 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.655C>T; p.R219W; 2:86788531-86788531 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.559G>T; p.A187S; 2:86789389-86789389 |
breast | carcinoma | Substitution - Missense |
c.351C>T; p.A117A; 2:86790380-86790380 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.573G>T; p.G191G; 2:86789375-86789375 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.653C>T; p.P218L; 2:86788533-86788533 |
skin | malignant_melanoma | Substitution - Missense |
c.196A>G; p.S66G; 2:86790535-86790535 |
breast | carcinoma | Substitution - Missense |