lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9219
Symbol	MTA2
Synonymous	MTA1L1\|PID
Full name	metastasis associated 1 family, member 2
Gene description	MTA1-L1 protein\|metastasis -associated gene 1-like 1\|metastasis associated gene family, member 2\|metastasis-associated 1-like 1\|metastasis-associated protein 2\|metastasis-associated protein MTA2\|p53 target protein in deacetylase complex
Cytoband	11q12-q13.1
Gene type	protein-coding
Synonymous	MIM:603947; HGNC:HGNC:7411; Ensembl:ENSG00000149480; HPRD:07233; Vega:OTTHUMG00000167684

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.881T>C; p.F294S; 11:62596638-62596638	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.466G>T; p.E156*; 11:62598048-62598048	thyroid	other; neoplasm	Substitution - Nonsense
c.1409G>T; p.R470M; 11:62595338-62595338	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.385delT; p.Y129fs*33; 11:62598129-62598129	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.479G>A; p.R160H; 11:62598035-62598035	large_intestine; colon	NS	Substitution - Missense
c.385delT; p.Y129fs*33; 11:62598129-62598129	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1678C>T; p.R560W; 11:62594530-62594530	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.299C>T; p.T100I; 11:62598531-62598531	skin; arm	malignant_melanoma	Substitution - Missense
c.307C>T; p.R103W; 11:62598523-62598523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1683C>T; p.A561A; 11:62594525-62594525	skin	malignant_melanoma	Substitution - coding silent
c.307C>T; p.R103W; 11:62598523-62598523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>T; p.Q144*; 11:62598084-62598084	breast	carcinoma	Substitution - Nonsense
c.1986G>A; p.E662E; 11:62593896-62593896	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1603C>T; p.P535S; 11:62594605-62594605	skin	malignant_melanoma	Substitution - Missense
c.1718C>T; p.S573F; 11:62594382-62594382	skin	malignant_melanoma	Substitution - Missense
c.1016+5G>A; p.?; 11:62596274-62596274	liver	carcinoma	Unknown
c.1016+5G>A; p.?; 11:62596274-62596274	liver	carcinoma	Unknown
c.1609G>A; p.G537S; 11:62594599-62594599	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.93C>T; p.N31N; 11:62600625-62600625	skin	malignant_melanoma	Substitution - coding silent
c.1382T>C; p.L461P; 11:62595365-62595365	lung; left_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1906C>T; p.L636L; 11:62593976-62593976	skin	malignant_melanoma	Substitution - coding silent
c.1507G>A; p.A503T; 11:62595047-62595047	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.1017-1G>A; p.?; 11:62596108-62596108	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1068G>A; p.M356I; 11:62596056-62596056	breast	carcinoma	Substitution - Missense
c.1017-1G>A; p.?; 11:62596108-62596108	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.823C>T; p.L275L; 11:62596696-62596696	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.910G>T; p.V304F; 11:62596505-62596505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.82G>C; p.E28Q; 11:62600636-62600636	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1438C>T; p.R480*; 11:62595309-62595309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.188C>T; p.A63V; 11:62600168-62600168	urinary_tract; bladder	carcinoma	Substitution - Missense
c.188C>T; p.A63V; 11:62600168-62600168	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.354C>T; p.S118S; 11:62598345-62598345	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.373G>T; p.D125Y; 11:62598141-62598141	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.373G>T; p.D125Y; 11:62598141-62598141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.337G>T; p.E113*; 11:62598362-62598362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1493G>A; p.R498Q; 11:62595061-62595061	liver	carcinoma	Substitution - Missense
c.694-1G>C; p.?; 11:62596826-62596826	ovary	carcinoma; serous_carcinoma	Unknown
c.1493G>A; p.R498Q; 11:62595061-62595061	liver	carcinoma	Substitution - Missense
c.790G>A; p.E264K; 11:62596729-62596729	urinary_tract; bladder	carcinoma	Substitution - Missense
c.343G>C; p.D115H; 11:62598356-62598356	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>T; p.I190I; 11:62597633-62597633	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.457T>C; p.Y153H; 11:62598057-62598057	skin	malignant_melanoma	Substitution - Missense
c.438G>A; p.E146E; 11:62598076-62598076	breast	carcinoma	Substitution - coding silent
c.139C>T; p.R47W; 11:62600217-62600217	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1600delA; p.T534fs*25; 11:62594608-62594608	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.222G>C; p.G74G; 11:62598608-62598608	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1323C>T; p.A441A; 11:62595424-62595424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1913T>G; p.V638G; 11:62593969-62593969	breast	carcinoma	Substitution - Missense
c.656A>C; p.H219P; 11:62597353-62597353	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1070A>G; p.N357S; 11:62596054-62596054	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1321G>A; p.A441T; 11:62595426-62595426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1531C>T; p.P511S; 11:62595023-62595023	skin	malignant_melanoma	Substitution - Missense
c.657C>G; p.H219Q; 11:62597352-62597352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1889G>C; p.R630P; 11:62593993-62593993	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1151C>G; p.P384R; 11:62595855-62595855	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1846C>A; p.L616I; 11:62594036-62594036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.406G>A; p.V136M; 11:62598108-62598108	prostate	carcinoma	Substitution - Missense
c.1176T>G; p.A392A; 11:62595830-62595830	skin	malignant_melanoma	Substitution - coding silent
c.238C>T; p.R80C; 11:62598592-62598592	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.325A>G; p.T109A; 11:62598374-62598374	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718delA; p.R240fs*41; 11:62596801-62596801	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1965A>C; p.S655S; 11:62593917-62593917	thyroid	other; neoplasm	Substitution - coding silent
c.1142G>A; p.W381*; 11:62595864-62595864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1923G>A; p.T641T; 11:62593959-62593959	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.256C>A; p.R86R; 11:62598574-62598574	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.373-6T>C; p.?; 11:62598147-62598147	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1843G>C; p.A615P; 11:62594039-62594039	prostate	carcinoma	Substitution - Missense
c.1375A>G; p.T459A; 11:62595372-62595372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1232A>G; p.E411G; 11:62595774-62595774	prostate	adenoma	Substitution - Missense
c.809C>T; p.A270V; 11:62596710-62596710	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.A270V; 11:62596710-62596710	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.A270V; 11:62596710-62596710	large_intestine; colon	carcinoma	Substitution - Missense
c.809C>T; p.A270V; 11:62596710-62596710	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.301delC; p.H101fs*8; 11:62598529-62598529	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1041C>T; p.I347I; 11:62596083-62596083	skin	malignant_melanoma	Substitution - coding silent
c.1463C>T; p.A488V; 11:62595284-62595284	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.92A>G; p.N31S; 11:62600626-62600626	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1298G>A; p.S433N; 11:62595449-62595449	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1488C>T; p.S496S; 11:62595066-62595066	skin	malignant_melanoma	Substitution - coding silent
c.122A>C; p.K41T; 11:62600234-62600234	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.L141F; 11:62598093-62598093	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.848A>G; p.Y283C; 11:62596671-62596671	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.848A>G; p.Y283C; 11:62596671-62596671	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.339G>T; p.E113D; 11:62598360-62598360	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1453C>T; p.P485S; 11:62595294-62595294	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1357A>C; p.T453P; 11:62595390-62595390	thyroid	other; neoplasm	Substitution - Missense
c.1567G>T; p.D523Y; 11:62594987-62594987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.889T>C; p.W297R; 11:62596526-62596526	central_nervous_system; brain	glioma	Substitution - Missense
c.133C>T; p.L45F; 11:62600223-62600223	skin	malignant_melanoma	Substitution - Missense
c.1578C>T; p.A526A; 11:62594630-62594630	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1874T>G; p.M625R; 11:62594008-62594008	central_nervous_system; brain	glioma	Substitution - Missense
c.1664delG; p.G555fs*4; 11:62594544-62594544	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1664delG; p.G555fs*4; 11:62594544-62594544	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1936C>T; p.R646W; 11:62593946-62593946	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.221G>A; p.G74E; 11:62598609-62598609	urinary_tract; bladder	carcinoma	Substitution - Missense
c.221G>A; p.G74E; 11:62598609-62598609	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1853A>G; p.K618R; 11:62594029-62594029	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1850G>A; p.R617Q; 11:62594032-62594032	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.405C>T; p.P135P; 11:62598109-62598109	pancreas	carcinoma	Substitution - coding silent
c.405C>T; p.P135P; 11:62598109-62598109	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1916A>C; p.K639T; 11:62593966-62593966	thyroid	other; neoplasm	Substitution - Missense
c.982G>C; p.D328H; 11:62596313-62596313	urinary_tract; bladder	carcinoma	Substitution - Missense
c.319A>T; p.S107C; 11:62598380-62598380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1746G>C; p.G582G; 11:62594354-62594354	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.311G>A; p.G104E; 11:62598388-62598388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.311G>A; p.G104E; 11:62598388-62598388	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1832A>T; p.K611M; 11:62594268-62594268	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1832A>T; p.K611M; 11:62594268-62594268	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1255-2A>G; p.?; 11:62595494-62595494	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1994T>A; p.V665D; 11:62593888-62593888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1996C>T; p.L666L; 11:62593886-62593886	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1782G>A; p.Q594Q; 11:62594318-62594318	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1442G>A; p.R481Q; 11:62595305-62595305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1664_1665insG; p.I556fs*8; 11:62594543-62594544	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.765G>T; p.Q255H; 11:62596754-62596754	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1560C>T; p.I520I; 11:62594994-62594994	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.785G>A; p.R262Q; 11:62596734-62596734	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.785G>A; p.R262Q; 11:62596734-62596734	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2005T>A; p.*669R; 11:62593877-62593877	stomach	carcinoma; adenocarcinoma	Nonstop extension
c.593+9T>G; p.?; 11:62597601-62597601	ovary	other; neoplasm	Unknown
c.534C>T; p.V178V; 11:62597669-62597669	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.317G>A; p.C106Y; 11:62598382-62598382	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.435C>T; p.G145G; 11:62598079-62598079	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.866A>G; p.D289G; 11:62596653-62596653	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1701G>A; p.G567G; 11:62594399-62594399	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation