lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	920
Symbol	CD4
Synonymous	CD4mut
Full name	CD4 molecule
Gene description	CD4 antigen (p55)\|CD4 receptor\|T-cell surface antigen T4/Leu-3\|T-cell surface glycoprotein CD4
Cytoband	12p13.31
Gene type	protein-coding
Synonymous	MIM:186940; HGNC:HGNC:1678; Ensembl:ENSG00000010610; HPRD:01740; Vega:OTTHUMG00000168514

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.515C>T; p.S172F; 12:6814900-6814900	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.539G>A; p.G180D; 12:6814924-6814924	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1171T>G; p.S391A; 12:6818435-6818435	thyroid	other; neoplasm	Substitution - Missense
c.365T>C; p.V122A; 12:6814292-6814292	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.516T>A; p.S172S; 12:6814901-6814901	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.672A>T; p.P224P; 12:6816120-6816120	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1219G>A; p.G407S; 12:6818483-6818483	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.606_607+8delAGGTAAGGGA; p.?; 12:6814991-6815000	breast	carcinoma	Unknown
c.167C>T; p.S56F; 12:6800424-6800424	skin	malignant_melanoma	Substitution - Missense
c.167C>T; p.S56F; 12:6800424-6800424	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.573G>A; p.K191K; 12:6814958-6814958	skin	malignant_melanoma	Substitution - coding silent
c.1065G>T; p.E355D; 12:6817239-6817239	breast	carcinoma	Substitution - Missense
c.92G>A; p.G31D; 12:6800349-6800349	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.97A>T; p.K33*; 12:6800354-6800354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.846C>T; p.L282L; 12:6816294-6816294	meninges	meningioma	Substitution - coding silent
c.1173C>T; p.S391S; 12:6818437-6818437	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1330A>C; p.T444P; 12:6818898-6818898	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.683C>A; p.T228K; 12:6816131-6816131	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.218C>T; p.P73L; 12:6814145-6814145	skin	malignant_melanoma	Substitution - Missense
c.709G>A; p.E237K; 12:6816157-6816157	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>T; p.N55N; 12:6800422-6800422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.807C>T; p.D269D; 12:6816255-6816255	skin	malignant_melanoma	Substitution - coding silent
c.58C>T; p.P20S; 12:6800315-6800315	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.836C>T; p.P279L; 12:6816284-6816284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1163C>A; p.P388H; 12:6818427-6818427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1026G>A; p.L342L; 12:6817200-6817200	skin	malignant_melanoma	Substitution - coding silent
c.492delG; p.K167fs*31; 12:6814877-6814877	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.492delG; p.K167fs*31; 12:6814877-6814877	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.492delG; p.K167fs*31; 12:6814877-6814877	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.492delG; p.K167fs*31; 12:6814877-6814877	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.492delG; p.K167fs*31; 12:6814877-6814877	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.492delG; p.K167fs*31; 12:6814877-6814877	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.378T>C; p.T126T; 12:6814763-6814763	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.277C>A; p.P93T; 12:6814204-6814204	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.808C>T; p.P270S; 12:6816256-6816256	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1038C>G; p.N346K; 12:6817212-6817212	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.561G>A; p.L187L; 12:6814946-6814946	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.752G>T; p.W251L; 12:6816200-6816200	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.72G>T; p.Q24H; 12:6800329-6800329	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.509C>T; p.S170F; 12:6814894-6814894	urinary_tract; bladder	carcinoma	Substitution - Missense
c.765C>T; p.D255D; 12:6816213-6816213	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.472C>T; p.P158S; 12:6814857-6814857	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.589A>G; p.I197V; 12:6814974-6814974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>T; p.V37L; 12:6800366-6800366	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.E102K; 12:6814231-6814231	breast	carcinoma	Substitution - Missense
c.1278G>A; p.R426R; 12:6818542-6818542	skin	malignant_melanoma	Substitution - coding silent
c.956-2A>T; p.?; 12:6817128-6817128	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.956-2A>T; p.?; 12:6817128-6817128	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.511G>T; p.V171L; 12:6814896-6814896	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1055C>T; p.S352L; 12:6817229-6817229	kidney	other; neoplasm	Substitution - Missense
c.1055C>T; p.S352L; 12:6817229-6817229	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.345G>A; p.K115K; 12:6814272-6814272	skin	malignant_melanoma	Substitution - coding silent
c.1095G>A; p.A365A; 12:6817269-6817269	breast	carcinoma	Substitution - coding silent
c.676G>T; p.A226S; 12:6816124-6816124	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.237C>T; p.R79R; 12:6814164-6814164	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1077G>T; p.W359C; 12:6817251-6817251	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.522G>A; p.L174L; 12:6814907-6814907	skin	malignant_melanoma	Substitution - coding silent
c.1213G>A; p.V405I; 12:6818477-6818477	thyroid	carcinoma	Substitution - Missense
c.154C>T; p.H52Y; 12:6800411-6800411	skin	malignant_melanoma	Substitution - Missense
c.1233C>T; p.F411F; 12:6818497-6818497	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.675C>T; p.L225L; 12:6816123-6816123	skin	malignant_melanoma	Substitution - coding silent
c.675C>T; p.L225L; 12:6816123-6816123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.346G>A; p.E116K; 12:6814273-6814273	skin	malignant_melanoma	Substitution - Missense
c.520C>G; p.L174V; 12:6814905-6814905	breast	carcinoma	Substitution - Missense
c.286A>G; p.I96V; 12:6814213-6814213	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1371C>A; p.P457P; 12:6819323-6819323	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.268G>A; p.G90R; 12:6814195-6814195	skin	malignant_melanoma	Substitution - Missense
c.639G>T; p.K213N; 12:6816087-6816087	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.408G>A; p.G136G; 12:6814793-6814793	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1279C>T; p.R427C; 12:6818847-6818847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.756C>T; p.I252I; 12:6816204-6816204	breast	carcinoma	Substitution - coding silent
c.872A>G; p.Y291C; 12:6816320-6816320	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1212C>T; p.G404G; 12:6818476-6818476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.344_346delAGG; p.E117delE; 12:6814271-6814273	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1020G>T; p.L340L; 12:6817194-6817194	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1317C>T; p.L439L; 12:6818885-6818885	skin	malignant_melanoma	Substitution - coding silent
c.731G>A; p.R244K; 12:6816179-6816179	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.856C>T; p.Q286*; 12:6816304-6816304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.807C>A; p.D269E; 12:6816255-6816255	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.809C>A; p.P270H; 12:6816257-6816257	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1238G>C; p.G413A; 12:6818502-6818502	skin	malignant_melanoma	Substitution - Missense
c.597C>T; p.I199I; 12:6814982-6814982	ovary	other; neoplasm	Substitution - coding silent
c.379G>A; p.A127T; 12:6814764-6814764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1042G>A; p.E348K; 12:6817216-6817216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.481A>C; p.K161Q; 12:6814866-6814866	pancreas	carcinoma	Substitution - Missense
c.1347-1G>A; p.?; 12:6819298-6819298	breast	carcinoma	Unknown
c.844C>T; p.L282F; 12:6816292-6816292	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.837G>A; p.P279P; 12:6816285-6816285	breast	carcinoma	Substitution - coding silent
c.1358A>G; p.K453R; 12:6819310-6819310	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1086C>T; p.N362N; 12:6817260-6817260	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.944T>C; p.V315A; 12:6816392-6816392	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.230A>T; p.N77I; 12:6814157-6814157	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.168C>T; p.S56S; 12:6800425-6800425	skin	malignant_melanoma	Substitution - coding silent
c.1191G>A; p.M397I; 12:6818455-6818455	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.513G>A; p.V171V; 12:6814898-6814898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.236G>A; p.R79H; 12:6814163-6814163	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1341T>C; p.C447C; 12:6818909-6818909	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.269G>A; p.G90E; 12:6814196-6814196	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.Q268H; 12:6816252-6816252	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1089T>C; p.P363P; 12:6817263-6817263	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1035G>A; p.E345E; 12:6817209-6817209	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1216G>A; p.A406T; 12:6818480-6818480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.665C>T; p.S222F; 12:6816113-6816113	skin	malignant_melanoma	Substitution - Missense
c.697A>T; p.T233S; 12:6816145-6816145	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.793C>T; p.R265W; 12:6816241-6816241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation