lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9122
Symbol	SLC16A4
Synonymous	MCT4\|MCT5
Full name	solute carrier family 16, member 4
Gene description	MCT 4\|MCT 5\|monocarboxylate transporter 4\|monocarboxylate transporter 5\|solute carrier family 16 (monocarboxylic acid transporters), member 4\|solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
Cytoband	1p13.3
Gene type	protein-coding
Synonymous	MIM:603878; HGNC:HGNC:10925; Ensembl:ENSG00000168679; HPRD:04855; Vega:OTTHUMG00000011285

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.989G>T; p.G330V; 1:110378894-110378894	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1187C>A; p.T396N; 1:110377005-110377005	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1319C>A; p.S440Y; 1:110375475-110375475	oesophagus	carcinoma	Substitution - Missense
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1056T>G; p.I352M; 1:110377136-110377136	breast	carcinoma	Substitution - Missense
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425delT; p.F475fs*12; 1:110363805-110363805	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.428G>A; p.R143Q; 1:110381080-110381080	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.471G>A; p.L157L; 1:110381037-110381037	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.88-1G>A; p.?; 1:110382967-110382967	skin	malignant_melanoma	Unknown
c.646T>C; p.S216P; 1:110379237-110379237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.642T>C; p.S214S; 1:110379241-110379241	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.912T>C; p.F304F; 1:110378971-110378971	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.183G>C; p.W61C; 1:110382871-110382871	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.907A>G; p.I303V; 1:110378976-110378976	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.307A>T; p.I103F; 1:110381709-110381709	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.723T>G; p.T241T; 1:110379160-110379160	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.768A>C; p.Q256H; 1:110379115-110379115	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.11G>A; p.R4K; 1:110389313-110389313	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455G>A; p.R152H; 1:110381053-110381053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.92A>G; p.N31S; 1:110382962-110382962	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.398_399delCT; p.A133fs*40; 1:110381109-110381110	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1357delC; p.Q453fs*34; 1:110363873-110363873	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1207G>A; p.A403T; 1:110376985-110376985	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.285C>T; p.F95F; 1:110381731-110381731	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.285C>T; p.F95F; 1:110381731-110381731	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.145C>T; p.Q49*; 1:110382909-110382909	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.345G>A; p.V115V; 1:110381671-110381671	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1437C>G; p.A479A; 1:110363793-110363793	skin	malignant_melanoma	Substitution - coding silent
c.1383C>A; p.F461L; 1:110363847-110363847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1424_1425delTT; p.F475fs*>13; 1:110363805-110363806	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.157G>A; p.E53K; 1:110382897-110382897	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.920C>G; p.S307C; 1:110378963-110378963	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1296C>G; p.F432L; 1:110375498-110375498	oesophagus	carcinoma	Substitution - Missense
c.1044G>A; p.T348T; 1:110377148-110377148	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.294T>C; p.T98T; 1:110381722-110381722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.294T>C; p.T98T; 1:110381722-110381722	liver	carcinoma	Substitution - coding silent
c.294T>C; p.T98T; 1:110381722-110381722	liver	carcinoma	Substitution - coding silent
c.919T>C; p.S307P; 1:110378964-110378964	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1015C>T; p.L339F; 1:110378868-110378868	breast	carcinoma	Substitution - Missense
c.284T>C; p.F95S; 1:110381732-110381732	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.87+3A>G; p.?; 1:110389234-110389234	liver	carcinoma	Unknown
c.599T>C; p.I200T; 1:110379284-110379284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.466G>A; p.G156R; 1:110381042-110381042	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.600C>G; p.I200M; 1:110379283-110379283	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.12G>A; p.R4R; 1:110389312-110389312	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.548C>G; p.A183G; 1:110379335-110379335	breast	carcinoma	Substitution - Missense
c.195C>T; p.I65I; 1:110382859-110382859	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.790A>C; p.N264H; 1:110379093-110379093	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.790A>C; p.N264H; 1:110379093-110379093	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.220+4T>C; p.?; 1:110382830-110382830	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Unknown
c.685T>A; p.C229S; 1:110379198-110379198	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.415T>A; p.Y139N; 1:110381093-110381093	skin	malignant_melanoma	Substitution - Missense
c.221G>C; p.G74A; 1:110381795-110381795	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.470T>C; p.L157P; 1:110381038-110381038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.293C>T; p.T98I; 1:110381723-110381723	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.149A>G; p.E50G; 1:110382905-110382905	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.149A>G; p.E50G; 1:110382905-110382905	stomach	adenocarcinoma	Substitution - Missense
c.1426_1427insT; p.P477fs*>12; 1:110363803-110363804	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.1453A>G; p.S485G; 1:110363777-110363777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.526+2T>C; p.?; 1:110380980-110380980	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.180_181insA; p.W61fs*22; 1:110382873-110382874	pancreas	carcinoma	Insertion - Frameshift
c.180_181insA; p.W61fs*22; 1:110382873-110382874	pancreas	carcinoma	Insertion - Frameshift
c.1430C>T; p.P477L; 1:110363800-110363800	skin; mucosal	malignant_melanoma	Substitution - Missense
c.723T>C; p.T241T; 1:110379160-110379160	liver	carcinoma	Substitution - coding silent
c.755T>G; p.L252*; 1:110379128-110379128	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.921T>C; p.S307S; 1:110378962-110378962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.921T>C; p.S307S; 1:110378962-110378962	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.921T>C; p.S307S; 1:110378962-110378962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.921T>C; p.S307S; 1:110378962-110378962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.179_180insA; p.W61fs*22; 1:110382874-110382875	pancreas	carcinoma; ductal_carcinoma	Insertion - Frameshift
c.179_180insA; p.W61fs*22; 1:110382874-110382875	pancreas	carcinoma; ductal_carcinoma	Insertion - Frameshift
c.1194C>T; p.C398C; 1:110376998-110376998	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026A>G; p.V342V; 1:110378857-110378857	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.364G>A; p.G122S; 1:110381652-110381652	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1425_1426insT; p.V476fs*>13; 1:110363804-110363805	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation