lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	90780
Symbol	PYGO2
Synonymous	1190004M21Rik
Full name	pygopus family PHD finger 2
Gene description	pygopus 2\|pygopus homolog 2
Cytoband	1q21.3
Gene type	protein-coding
Synonymous	MIM:606903; HGNC:HGNC:30257; Ensembl:ENSG00000163348; HPRD:06065; Vega:OTTHUMG00000037370

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1126G>A; p.V376I; 1:154958874-154958874	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145A>C; p.N49H; 1:154960985-154960985	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.574C>T; p.P192S; 1:154959426-154959426	skin	malignant_melanoma	Substitution - Missense
c.495A>G; p.Q165Q; 1:154959505-154959505	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.574C>T; p.P192S; 1:154959426-154959426	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.194delC; p.P65fs*96; 1:154959806-154959806	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.157C>T; p.P53S; 1:154959843-154959843	urinary_tract; bladder	carcinoma	Substitution - Missense
c.153+2T>G; p.?; 1:154960975-154960975	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.727C>A; p.P243T; 1:154959273-154959273	liver	carcinoma	Substitution - Missense
c.488C>T; p.P163L; 1:154959512-154959512	breast	carcinoma	Substitution - Missense
c.376C>T; p.P126S; 1:154959624-154959624	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.571G>T; p.G191C; 1:154959429-154959429	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.330G>C; p.M110I; 1:154959670-154959670	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.945T>G; p.G315G; 1:154959055-154959055	thyroid	other; neoplasm	Substitution - coding silent
c.967C>T; p.P323S; 1:154959033-154959033	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1066C>T; p.R356C; 1:154958934-154958934	large_intestine; colon	adenoma	Substitution - Missense
c.405delC; p.F136fs*25; 1:154959595-154959595	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.129G>T; p.K43N; 1:154961001-154961001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.803C>T; p.S268F; 1:154959197-154959197	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.G142G; 1:154959574-154959574	skin	malignant_melanoma	Substitution - coding silent
c.389G>A; p.R130H; 1:154959611-154959611	liver	carcinoma	Substitution - Missense
c.677C>T; p.P226L; 1:154959323-154959323	skin	malignant_melanoma	Substitution - Missense
c.448delC; p.Q150fs*11; 1:154959552-154959552	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.448delC; p.Q150fs*11; 1:154959552-154959552	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.448delC; p.Q150fs*11; 1:154959552-154959552	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.448delC; p.Q150fs*11; 1:154959552-154959552	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.448delC; p.Q150fs*11; 1:154959552-154959552	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.640C>T; p.R214*; 1:154959360-154959360	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1067G>C; p.R356P; 1:154958933-154958933	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1001G>A; p.R334Q; 1:154958999-154958999	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.333G>A; p.A111A; 1:154959667-154959667	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.839C>T; p.P280L; 1:154959161-154959161	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.616C>A; p.L206M; 1:154959384-154959384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.486T>C; p.F162F; 1:154959514-154959514	oesophagus	carcinoma	Substitution - coding silent
c.1101G>A; p.G367G; 1:154958899-154958899	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.409C>G; p.P137A; 1:154959591-154959591	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.840G>A; p.P280P; 1:154959160-154959160	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.991G>A; p.G331S; 1:154959009-154959009	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.446C>T; p.P149L; 1:154959554-154959554	skin	malignant_melanoma	Substitution - Missense
c.646G>A; p.A216T; 1:154959354-154959354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.446C>T; p.P149L; 1:154959554-154959554	skin	malignant_melanoma	Substitution - Missense
c.468C>T; p.P156P; 1:154959532-154959532	skin	malignant_melanoma	Substitution - coding silent
c.1105C>T; p.L369L; 1:154958895-154958895	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.641G>A; p.R214Q; 1:154959359-154959359	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.374G>C; p.G125A; 1:154959626-154959626	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.374G>C; p.G125A; 1:154959626-154959626	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.550C>A; p.P184T; 1:154959450-154959450	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.550C>A; p.P184T; 1:154959450-154959450	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.346C>T; p.P116S; 1:154959654-154959654	urinary_tract; bladder	carcinoma	Substitution - Missense
c.122C>T; p.P41L; 1:154961008-154961008	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.385C>T; p.L129F; 1:154959615-154959615	skin	malignant_melanoma	Substitution - Missense
c.702C>T; p.L234L; 1:154959298-154959298	skin	malignant_melanoma	Substitution - coding silent
c.230C>T; p.P77L; 1:154959770-154959770	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.866_867CC>TT; p.P289L; 1:154959133-154959134	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282C>T; p.F94F; 1:154959718-154959718	skin	malignant_melanoma	Substitution - coding silent
c.530C>A; p.P177H; 1:154959470-154959470	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>T; p.F104F; 1:154959688-154959688	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.138G>T; p.R46S; 1:154960992-154960992	thyroid	other; neoplasm	Substitution - Missense
c.138G>T; p.R46S; 1:154960992-154960992	urinary_tract; bladder	carcinoma	Substitution - Missense
c.138G>C; p.R46S; 1:154960992-154960992	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.970C>A; p.P324T; 1:154959030-154959030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.448_449insC; p.Q150fs*27; 1:154959551-154959552	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.331G>A; p.A111T; 1:154959669-154959669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.448_449insC; p.Q150fs*27; 1:154959551-154959552	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.448_449insC; p.Q150fs*27; 1:154959551-154959552	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.448_449insC; p.Q150fs*27; 1:154959551-154959552	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.530C>T; p.P177L; 1:154959470-154959470	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.954C>T; p.S318S; 1:154959046-154959046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation