lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9075
Symbol	CLDN2
Synonymous	-
Full name	claudin 2
Gene description	SP82\|claudin-2
Cytoband	Xq22.3-q23
Gene type	protein-coding
Synonymous	MIM:300520; HGNC:HGNC:2041; Ensembl:ENSG00000165376; HPRD:06471; Vega:OTTHUMG00000022154

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.618G>A; p.R206R; 23:106928846-106928846	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.468G>T; p.M156I; 23:106928696-106928696	skin	malignant_melanoma	Substitution - Missense
c.156G>A; p.M52I; 23:106928384-106928384	skin	malignant_melanoma	Substitution - Missense
c.217C>A; p.L73M; 23:106928445-106928445	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.258_259insT; p.S87fs*68; 23:106928486-106928487	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.258_259insT; p.S87fs*68; 23:106928486-106928487	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.548T>A; p.F183Y; 23:106928776-106928776	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.323G>T; p.C108F; 23:106928551-106928551	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.682G>A; p.G228R; 23:106928910-106928910	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.414G>C; p.W138C; 23:106928642-106928642	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.433C>T; p.R145W; 23:106928661-106928661	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.468G>A; p.M156I; 23:106928696-106928696	urinary_tract; bladder	carcinoma	Substitution - Missense
c.468G>A; p.M156I; 23:106928696-106928696	skin	malignant_melanoma	Substitution - Missense
c.101C>A; p.S34Y; 23:106928329-106928329	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.366A>G; p.G122G; 23:106928594-106928594	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.167C>A; p.T56K; 23:106928395-106928395	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.167C>A; p.T56K; 23:106928395-106928395	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.161G>A; p.C54Y; 23:106928389-106928389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.100T>C; p.S34P; 23:106928328-106928328	kidney	other; neoplasm	Substitution - Missense
c.10C>A; p.L4I; 23:106928238-106928238	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.171_172delCA; p.H57fs*8; 23:106928399-106928400	large_intestine; colon	carcinoma	Deletion - Frameshift
c.385G>A; p.G129S; 23:106928613-106928613	skin	malignant_melanoma	Substitution - Missense
c.566G>T; p.R189I; 23:106928794-106928794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.150C>G; p.L50L; 23:106928378-106928378	breast	carcinoma	Substitution - coding silent
c.490_494delCTTTA; p.Y165fs*54; 23:106928718-106928722	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.369C>G; p.V123V; 23:106928597-106928597	breast	carcinoma	Substitution - coding silent
c.221_222CC>TT; p.P74L; 23:106928449-106928450	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.227A>G; p.D76G; 23:106928455-106928455	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.646A>C; p.K216Q; 23:106928874-106928874	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.363T>G; p.G121G; 23:106928591-106928591	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.16C>A; p.L6I; 23:106928244-106928244	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.165_166delCA; p.H57fs*8; 23:106928393-106928394	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.215G>A; p.G72D; 23:106928443-106928443	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.60C>A; p.G20G; 23:106928288-106928288	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.426G>A; p.G142G; 23:106928654-106928654	skin	malignant_melanoma	Substitution - coding silent
c.166A>G; p.T56A; 23:106928394-106928394	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.328G>A; p.E110K; 23:106928556-106928556	skin	malignant_melanoma	Substitution - Missense
c.161G>T; p.C54F; 23:106928389-106928389	skin	malignant_melanoma	Substitution - Missense
c.101C>T; p.S34F; 23:106928329-106928329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.410C>T; p.A137V; 23:106928638-106928638	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.410C>T; p.A137V; 23:106928638-106928638	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.429C>A; p.I143I; 23:106928657-106928657	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.325C>T; p.Q109*; 23:106928553-106928553	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation