lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9074
Symbol	CLDN6
Synonymous	-
Full name	claudin 6
Gene description	claudin-6\|skullin
Cytoband	16p13.3
Gene type	protein-coding
Synonymous	MIM:615798; HGNC:HGNC:2048; Ensembl:ENSG00000184697; HPRD:13070

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.95T>G; p.V32G; 16:3015927-3015927	breast	carcinoma	Substitution - Missense
c.159C>T; p.S53S; 16:3015863-3015863	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.273C>A; p.A91A; 16:3015749-3015749	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.508G>A; p.A170T; 16:3015514-3015514	skin	malignant_melanoma	Substitution - Missense
c.226G>A; p.D76N; 16:3015796-3015796	skin	malignant_melanoma	Substitution - Missense
c.434G>A; p.R145Q; 16:3015588-3015588	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.427A>G; p.I143V; 16:3015595-3015595	breast	carcinoma	Substitution - Missense
c.427A>G; p.I143V; 16:3015595-3015595	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.427A>G; p.I143V; 16:3015595-3015595	thyroid	other; neoplasm	Substitution - Missense
c.427A>G; p.I143V; 16:3015595-3015595	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.216G>T; p.A72A; 16:3015806-3015806	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.403C>G; p.P135A; 16:3015619-3015619	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.419C>T; p.A140V; 16:3015603-3015603	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.419C>T; p.A140V; 16:3015603-3015603	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.472C>G; p.R158G; 16:3015550-3015550	skin	malignant_melanoma	Substitution - Missense
c.305C>T; p.A102V; 16:3015717-3015717	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.635C>T; p.S212F; 16:3015387-3015387	skin	malignant_melanoma	Substitution - Missense
c.602C>G; p.S201*; 16:3015420-3015420	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.345C>T; p.A115A; 16:3015677-3015677	pancreas	carcinoma	Substitution - coding silent
c.367A>C; p.I123L; 16:3015655-3015655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.V220I; 16:3015364-3015364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.V220I; 16:3015364-3015364	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.V220I; 16:3015364-3015364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>A; p.E110E; 16:3015692-3015692	skin	malignant_melanoma	Substitution - coding silent
c.19C>A; p.Q7K; 16:3016003-3016003	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.420G>A; p.A140A; 16:3015602-3015602	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.365G>A; p.G122E; 16:3015657-3015657	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.124G>A; p.V42M; 16:3015898-3015898	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.557C>T; p.P186L; 16:3015465-3015465	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.266T>G; p.L89R; 16:3015756-3015756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.255C>T; p.V85V; 16:3015767-3015767	skin	malignant_melanoma	Substitution - coding silent
c.102T>C; p.A34A; 16:3015920-3015920	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.102T>C; p.A34A; 16:3015920-3015920	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.75T>C; p.C25C; 16:3015947-3015947	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.357C>T; p.L119L; 16:3015665-3015665	breast	carcinoma	Substitution - coding silent
c.88T>C; p.W30R; 16:3015934-3015934	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.217C>T; p.L73L; 16:3015805-3015805	ovary	other; neoplasm	Substitution - coding silent
c.456G>A; p.V152V; 16:3015566-3015566	skin	malignant_melanoma	Substitution - coding silent
c.318C>G; p.T106T; 16:3015704-3015704	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.328G>A; p.E110K; 16:3015694-3015694	skin	malignant_melanoma	Substitution - Missense
c.135G>T; p.V45V; 16:3015887-3015887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.196G>A; p.V66M; 16:3015826-3015826	skin	malignant_melanoma	Substitution - Missense
c.506C>T; p.A169V; 16:3015516-3015516	breast	carcinoma	Substitution - Missense
c.276G>C; p.L92L; 16:3015746-3015746	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.626G>T; p.R209L; 16:3015396-3015396	prostate	carcinoma	Substitution - Missense
c.157T>A; p.S53T; 16:3015865-3015865	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.177C>G; p.T59T; 16:3015845-3015845	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.177C>G; p.T59T; 16:3015845-3015845	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.38T>C; p.L13P; 16:3015984-3015984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.265C>T; p.L89F; 16:3015757-3015757	breast	carcinoma	Substitution - Missense
c.274C>T; p.L92L; 16:3015748-3015748	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.651G>C; p.K217N; 16:3015371-3015371	breast	carcinoma	Substitution - Missense
c.596G>A; p.R199H; 16:3015426-3015426	thyroid	carcinoma	Substitution - Missense
c.445A>G; p.N149D; 16:3015577-3015577	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.216G>A; p.A72A; 16:3015806-3015806	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.216G>A; p.A72A; 16:3015806-3015806	central_nervous_system; brain	glioma	Substitution - coding silent
c.85A>C; p.M29L; 16:3015937-3015937	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.295C>T; p.L99F; 16:3015727-3015727	skin	malignant_melanoma	Substitution - Missense
c.565G>A; p.G189R; 16:3015457-3015457	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.39G>A; p.L13L; 16:3015983-3015983	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.627G>A; p.R209R; 16:3015395-3015395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.569C>T; p.S190F; 16:3015453-3015453	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.511T>C; p.S171P; 16:3015511-3015511	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.657C>T; p.Y219Y; 16:3015365-3015365	stomach	adenocarcinoma	Substitution - coding silent
c.120C>T; p.I40I; 16:3015902-3015902	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.651G>T; p.K217N; 16:3015371-3015371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.418G>A; p.A140T; 16:3015604-3015604	skin	malignant_melanoma	Substitution - Missense
c.271G>A; p.A91T; 16:3015751-3015751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.560C>A; p.S187*; 16:3015462-3015462	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.156G>C; p.M52I; 16:3015866-3015866	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.537delG; p.L180fs*>41; 16:3015485-3015485	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.395C>T; p.T132M; 16:3015627-3015627	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.144G>T; p.E48D; 16:3015878-3015878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.162C>T; p.C54C; 16:3015860-3015860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.163G>A; p.V55M; 16:3015859-3015859	pancreas	carcinoma	Substitution - Missense
c.338C>T; p.S113F; 16:3015684-3015684	skin	malignant_melanoma	Substitution - Missense
c.99C>T; p.T33T; 16:3015923-3015923	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.99C>T; p.T33T; 16:3015923-3015923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation