lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9068
Symbol	ANGPTL1
Synonymous	ANG3\|ANGPT3\|ARP1\|AngY\|UNQ162\|dJ595C2.2
Full name	angiopoietin-like 1
Gene description	ANG-3\|angioarrestin\|angiopoietin 3\|angiopoietin Y1\|angiopoietin-3\|angiopoietin-like protein 1\|angiopoietin-related protein 1\|dJ595C2.2 (angiopoietin Y1)
Cytoband	1q25.2
Gene type	protein-coding
Synonymous	MIM:603874; HGNC:HGNC:489; Ensembl:ENSG00000116194; HPRD:04851; Vega:OTTHUMG00000035075

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1221G>A; p.G407G; 1:178852750-178852750	skin	malignant_melanoma	Substitution - coding silent
c.380A>G; p.N127S; 1:178865397-178865397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1014T>C; p.Y338Y; 1:178853597-178853597	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.714G>T; p.E238D; 1:178865063-178865063	breast	carcinoma	Substitution - Missense
c.841C>A; p.Q281K; 1:178853770-178853770	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.541T>C; p.S181P; 1:178865236-178865236	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.541T>C; p.S181P; 1:178865236-178865236	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.223A>G; p.T75A; 1:178865554-178865554	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.V177M; 1:178865248-178865248	skin	malignant_melanoma	Substitution - Missense
c.50A>G; p.D17G; 1:178865727-178865727	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1429T>C; p.S477P; 1:178851176-178851176	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>A; p.R241R; 1:178865054-178865054	skin	malignant_melanoma	Substitution - coding silent
c.537C>T; p.Y179Y; 1:178865240-178865240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413C>T; p.A471A; 1:178851192-178851192	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.130G>T; p.E44*; 1:178865647-178865647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.766G>A; p.A256T; 1:178865011-178865011	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>A; p.A286D; 1:178853754-178853754	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>A; p.A286D; 1:178853754-178853754	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>A; p.A286D; 1:178853754-178853754	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.979G>A; p.G327S; 1:178853632-178853632	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1154G>C; p.S385T; 1:178852817-178852817	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1154G>C; p.S385T; 1:178852817-178852817	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1160G>A; p.R387H; 1:178852811-178852811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1160G>A; p.R387H; 1:178852811-178852811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.350A>C; p.K117T; 1:178865427-178865427	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1160G>A; p.R387H; 1:178852811-178852811	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.459A>G; p.Q153Q; 1:178865318-178865318	thyroid	carcinoma	Substitution - coding silent
c.248T>C; p.M83T; 1:178865529-178865529	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.403A>G; p.M135V; 1:178865374-178865374	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432G>A; p.K144K; 1:178865345-178865345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.978C>A; p.D326E; 1:178853633-178853633	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.767C>A; p.A256E; 1:178865010-178865010	pancreas	carcinoma	Substitution - Missense
c.413T>G; p.L138*; 1:178865364-178865364	liver	carcinoma	Substitution - Nonsense
c.350A>G; p.K117R; 1:178865427-178865427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.902G>A; p.S301N; 1:178853709-178853709	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767C>A; p.A256E; 1:178865010-178865010	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1176T>C; p.S392S; 1:178852795-178852795	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.436G>A; p.D146N; 1:178865341-178865341	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.143A>C; p.K48T; 1:178865634-178865634	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.143A>C; p.K48T; 1:178865634-178865634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1108G>A; p.E370K; 1:178852863-178852863	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1280T>G; p.M427R; 1:178852691-178852691	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.339G>C; p.V113V; 1:178865438-178865438	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1291A>T; p.N431Y; 1:178851314-178851314	skin	malignant_melanoma	Substitution - Missense
c.1085A>G; p.Q362R; 1:178852886-178852886	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1333T>C; p.C445R; 1:178851272-178851272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.866C>T; p.S289L; 1:178853745-178853745	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.875G>A; p.G292E; 1:178853736-178853736	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.693T>A; p.P231P; 1:178865084-178865084	liver	carcinoma	Substitution - coding silent
c.693T>A; p.P231P; 1:178865084-178865084	liver	carcinoma	Substitution - coding silent
c.151T>C; p.Y51H; 1:178865626-178865626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1130A>C; p.K377T; 1:178852841-178852841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1369G>T; p.G457*; 1:178851236-178851236	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.159C>T; p.F53F; 1:178865618-178865618	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.805G>A; p.V269I; 1:178864972-178864972	skin	malignant_melanoma	Substitution - Missense
c.1355G>A; p.G452E; 1:178851250-178851250	thyroid	carcinoma	Substitution - Missense
c.208G>A; p.G70R; 1:178865569-178865569	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.740G>T; p.R247I; 1:178865037-178865037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.837C>A; p.D279E; 1:178853774-178853774	breast	carcinoma	Substitution - Missense
c.788C>A; p.P263H; 1:178864989-178864989	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.538G>A; p.A180T; 1:178865239-178865239	pancreas	carcinoma	Substitution - Missense
c.835G>A; p.D279N; 1:178853776-178853776	skin	malignant_melanoma	Substitution - Missense
c.141G>T; p.K47N; 1:178865636-178865636	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.616C>G; p.R206G; 1:178865161-178865161	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.141G>T; p.K47N; 1:178865636-178865636	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.141G>T; p.K47N; 1:178865636-178865636	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.329G>A; p.G110E; 1:178865448-178865448	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.760G>A; p.D254N; 1:178865017-178865017	lung	carcinoid-endocrine_tumour; atypical	Substitution - Missense
c.860G>A; p.G287E; 1:178853751-178853751	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1400G>A; p.G467E; 1:178851205-178851205	skin	malignant_melanoma	Substitution - Missense
c.1472A>C; p.D491A; 1:178851133-178851133	central_nervous_system; brain	glioma	Substitution - Missense
c.62G>T; p.C21F; 1:178865715-178865715	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.732T>A; p.G244G; 1:178865045-178865045	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.492A>C; p.E164D; 1:178865285-178865285	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.386G>A; p.R129H; 1:178865391-178865391	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1004G>T; p.W335L; 1:178853607-178853607	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.440A>C; p.N147T; 1:178865337-178865337	liver	carcinoma	Substitution - Missense
c.618A>C; p.R206R; 1:178865159-178865159	breast	carcinoma	Substitution - coding silent
c.697C>G; p.L233V; 1:178865080-178865080	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1006G>A; p.E336K; 1:178853605-178853605	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1312G>A; p.G438R; 1:178851293-178851293	skin	malignant_melanoma	Substitution - Missense
c.853G>T; p.E285*; 1:178853758-178853758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.518G>A; p.R173K; 1:178865259-178865259	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.115G>A; p.A39T; 1:178865662-178865662	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.160C>G; p.L54V; 1:178865617-178865617	breast	carcinoma	Substitution - Missense
c.971G>A; p.R324K; 1:178853640-178853640	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1370G>A; p.G457E; 1:178851235-178851235	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1455G>A; p.M485I; 1:178851150-178851150	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.40C>A; p.L14I; 1:178865737-178865737	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1455G>A; p.M485I; 1:178851150-178851150	urinary_tract; bladder	carcinoma	Substitution - Missense
c.616C>T; p.R206*; 1:178865161-178865161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation