lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9002
Symbol	F2RL3
Synonymous	PAR4
Full name	coagulation factor II (thrombin) receptor-like 3
Gene description	PAR-4\|protease-activated receptor-4\|proteinase-activated receptor 4\|thrombin receptor-like 3
Cytoband	19p12
Gene type	protein-coding
Synonymous	MIM:602779; HGNC:HGNC:3540; HPRD:04148

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.616G>A; p.A206T; 19:16890079-16890079	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1044G>A; p.R348R; 19:16890507-16890507	skin	malignant_melanoma	Substitution - coding silent
c.110-3C>T; p.?; 19:16889570-16889570	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.412C>T; p.R138C; 19:16889875-16889875	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.117G>A; p.T39T; 19:16889580-16889580	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.810G>A; p.T270T; 19:16890273-16890273	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.810G>A; p.T270T; 19:16890273-16890273	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.319delC; p.P107fs*9; 19:16889782-16889782	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.458C>T; p.T153M; 19:16889921-16889921	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.728C>T; p.P243L; 19:16890191-16890191	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.133G>T; p.A45S; 19:16889596-16889596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.299_300insG; p.V101fs*22; 19:16889762-16889763	pancreas	carcinoma	Insertion - Frameshift
c.214C>T; p.L72L; 19:16889677-16889677	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1089C>G; p.T363T; 19:16890552-16890552	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.912G>A; p.L304L; 19:16890375-16890375	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1077G>A; p.S359S; 19:16890540-16890540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1054C>T; p.R352W; 19:16890517-16890517	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1054C>T; p.R352W; 19:16890517-16890517	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.72C>T; p.S24S; 19:16889261-16889261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.815C>T; p.A272V; 19:16890278-16890278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.876C>T; p.A292A; 19:16890339-16890339	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.676G>A; p.V226M; 19:16890139-16890139	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.143G>A; p.G48D; 19:16889606-16889606	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1006G>A; p.D336N; 19:16890469-16890469	skin	malignant_melanoma	Substitution - Missense
c.114C>G; p.S38R; 19:16889577-16889577	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.691G>T; p.A231S; 19:16890154-16890154	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>T; p.R4*; 19:16889199-16889199	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.655C>T; p.R219W; 19:16890118-16890118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.11G>A; p.R4Q; 19:16889200-16889200	pancreas	carcinoma	Substitution - Missense
c.11G>A; p.R4Q; 19:16889200-16889200	pancreas	carcinoma	Substitution - Missense
c.764T>C; p.L255P; 19:16890227-16890227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.73G>T; p.V25F; 19:16889262-16889262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1036G>A; p.E346K; 19:16890499-16890499	skin	malignant_melanoma	Substitution - Missense
c.967G>A; p.V323M; 19:16890430-16890430	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.568C>T; p.R190W; 19:16890031-16890031	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1035C>T; p.A345A; 19:16890498-16890498	skin	malignant_melanoma	Substitution - coding silent
c.364G>A; p.D122N; 19:16889827-16889827	skin	malignant_melanoma	Substitution - Missense
c.980C>T; p.A327V; 19:16890443-16890443	meninges	meningioma; secretory	Substitution - Missense
c.966C>T; p.Y322Y; 19:16890429-16890429	pancreas	carcinoma	Substitution - coding silent
c.1118G>A; p.G373D; 19:16890581-16890581	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.666C>T; p.R222R; 19:16890129-16890129	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.829C>T; p.R277C; 19:16890292-16890292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930G>A; p.P310P; 19:16890393-16890393	liver	carcinoma	Substitution - coding silent
c.926_948del23; p.D309fs*>70; 19:16890389-16890411	breast	carcinoma	Deletion - Frameshift
c.930G>A; p.P310P; 19:16890393-16890393	liver	carcinoma	Substitution - coding silent
c.656G>A; p.R219Q; 19:16890119-16890119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.940G>A; p.A314T; 19:16890403-16890403	breast	carcinoma	Substitution - Missense
c.1045G>A; p.D349N; 19:16890508-16890508	skin	malignant_melanoma	Substitution - Missense
c.558C>T; p.A186A; 19:16890021-16890021	skin	malignant_melanoma	Substitution - coding silent
c.191C>A; p.P64Q; 19:16889654-16889654	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.897C>A; p.S299R; 19:16890360-16890360	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.805C>T; p.H269Y; 19:16890268-16890268	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>T; p.H269Y; 19:16890268-16890268	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1073G>A; p.R358Q; 19:16890536-16890536	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.952C>A; p.L318I; 19:16890415-16890415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.674G>A; p.R225H; 19:16890137-16890137	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.674G>A; p.R225H; 19:16890137-16890137	urinary_tract; bladder	carcinoma	Substitution - Missense
c.136C>A; p.P46T; 19:16889599-16889599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.542C>T; p.P181L; 19:16890005-16890005	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	thyroid	other; neoplasm	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.358G>A; p.A120T; 19:16889821-16889821	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.562C>T; p.R188C; 19:16890025-16890025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.790T>A; p.Y264N; 19:16890253-16890253	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.A249V; 19:16890209-16890209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>T; p.P46L; 19:16889600-16889600	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.544C>A; p.L182M; 19:16890007-16890007	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.544C>A; p.L182M; 19:16890007-16890007	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>T; p.P46L; 19:16889600-16889600	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.544C>A; p.L182M; 19:16890007-16890007	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>A; p.A236T; 19:16890169-16890169	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.974G>T; p.S325I; 19:16890437-16890437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation