lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	896
Symbol	CCND3
Synonymous	-
Full name	cyclin D3
Gene description	D3-type cyclin\|G1/S-specific cyclin-D3
Cytoband	6p21
Gene type	protein-coding
Synonymous	MIM:123834; HGNC:HGNC:1585; Ensembl:ENSG00000112576; HPRD:00452; Vega:OTTHUMG00000014690

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.574G>T; p.D192Y; 6:41937235-41937235	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.128C>T; p.S43F; 6:41941522-41941522	skin	malignant_melanoma	Substitution - Missense
c.815delG; p.G272fs*>21; 6:41936004-41936004	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.314T>A; p.V105D; 6:41940470-41940470	breast	carcinoma	Substitution - Missense
c.865_873GCCATACAC>C; p.A289fs*>2; 6:41935946-41935954	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Complex - frameshift
c.40C>T; p.R14W; 6:41941610-41941610	thyroid	other; neoplasm	Substitution - Missense
c.778C>T; p.Q260*; 6:41936041-41936041	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; angioimmunoblastic_T_cell_lymphoma	Substitution - Nonsense
c.778C>T; p.Q260*; 6:41936041-41936041	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Nonsense
c.643C>A; p.L215M; 6:41936627-41936627	pancreas	carcinoma	Substitution - Missense
c.731A>G; p.Q244R; 6:41936088-41936088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>T; p.L80L; 6:41940546-41940546	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.860T>A; p.V287D; 6:41935959-41935959	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.559G>A; p.A187T; 6:41937250-41937250	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>A; p.R72S; 6:41940570-41940570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225G>C; p.E75D; 6:41940559-41940559	urinary_tract; bladder	carcinoma	Substitution - Missense
c.107_108insT; p.E36fs*34; 6:41941542-41941543	breast	carcinoma	Insertion - Frameshift
c.869T>G; p.I290R; 6:41935950-41935950	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.869T>G; p.I290R; 6:41935950-41935950	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.222G>C; p.E74D; 6:41940562-41940562	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.826C>T; p.Q276*; 6:41935993-41935993	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Nonsense
c.826C>T; p.Q276*; 6:41935993-41935993	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.826C>T; p.Q276*; 6:41935993-41935993	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Nonsense
c.826C>T; p.Q276*; 6:41935993-41935993	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Nonsense
c.778C>G; p.Q260E; 6:41936041-41936041	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.113delA; p.Y38fs*45; 6:41941537-41941537	breast	carcinoma	Deletion - Frameshift
c.859G>A; p.V287I; 6:41935960-41935960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 6:41937295-41937295	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.721C>T; p.R241W; 6:41936098-41936098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.332C>A; p.S111Y; 6:41940452-41940452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>G; p.V77V; 6:41940553-41940553	liver	carcinoma	Substitution - coding silent
c.231C>G; p.V77V; 6:41940553-41940553	liver	carcinoma	Substitution - coding silent
c.667G>A; p.D223N; 6:41936603-41936603	skin	malignant_melanoma	Substitution - Missense
c.104delA; p.E35fs*48; 6:41941546-41941546	breast	carcinoma	Deletion - Frameshift
c.378C>G; p.I126M; 6:41940406-41940406	urinary_tract; bladder	carcinoma	Substitution - Missense
c.847A>G; p.T283A; 6:41935972-41935972	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.457G>A; p.A153T; 6:41937352-41937352	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.775T>G; p.S259A; 6:41936044-41936044	breast	carcinoma	Substitution - Missense
c.775T>G; p.S259A; 6:41936044-41936044	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.775T>G; p.S259A; 6:41936044-41936044	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.775T>G; p.S259A; 6:41936044-41936044	urinary_tract; bladder	carcinoma	Substitution - Missense
c.775T>G; p.S259A; 6:41936044-41936044	thyroid	other; neoplasm	Substitution - Missense
c.213G>A; p.Q71Q; 6:41940571-41940571	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.465G>A; p.V155V; 6:41937344-41937344	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.782C>G; p.T261S; 6:41936037-41936037	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.722G>A; p.R241Q; 6:41936097-41936097	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.811delC; p.R271fs*>22; 6:41936008-41936008	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.363C>G; p.I121M; 6:41940421-41940421	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>A; p.R50R; 6:41941500-41941500	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.150G>A; p.R50R; 6:41941500-41941500	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.705T>C; p.T235T; 6:41936565-41936565	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.765C>T; p.L255L; 6:41936054-41936054	breast	carcinoma	Substitution - coding silent
c.847A>C; p.T283P; 6:41935972-41935972	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.865G>C; p.A289P; 6:41935954-41935954	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.869T>A; p.I290K; 6:41935950-41935950	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.869T>A; p.I290K; 6:41935950-41935950	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.869T>A; p.I290K; 6:41935950-41935950	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.860T>G; p.V287G; 6:41935959-41935959	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.850C>T; p.P284S; 6:41935969-41935969	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.850C>T; p.P284S; 6:41935969-41935969	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.850C>T; p.P284S; 6:41935969-41935969	pancreas	carcinoma	Substitution - Missense
c.850C>T; p.P284S; 6:41935969-41935969	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.851C>T; p.P284L; 6:41935968-41935968	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.851C>T; p.P284L; 6:41935968-41935968	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.833C>G; p.P278R; 6:41935986-41935986	breast	carcinoma	Substitution - Missense
c.343G>A; p.E115K; 6:41940441-41940441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.811_812insC; p.R271fs*>23; 6:41936007-41936008	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Insertion - Frameshift
c.811_812insC; p.R271fs*>23; 6:41936007-41936008	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Insertion - Frameshift
c.811_812insC; p.R271fs*>23; 6:41936007-41936008	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation