lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8935
Symbol	SKAP2
Synonymous	PRAP\|RA70\|SAPS\|SCAP2\|SKAP-HOM\|SKAP55R
Full name	src kinase associated phosphoprotein 2
Gene description	Fyn-associated phosphoprotein SKAP55 homologue\|Pyk2/RAFTK-associated protein\|SKAP-55HOM\|SKAP55 homolog\|retinoic acid-induced protein 70\|src family-associated phosphoprotein 2\|src kinase-associated phosphoprotein 2\|src kinase-associated phosphoprotein of 5
Cytoband	7p15.2
Gene type	protein-coding
Synonymous	MIM:605215; HGNC:HGNC:15687; Ensembl:ENSG00000005020; HPRD:05558; Vega:OTTHUMG00000023495

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.290A>G; p.D97G; 7:26844047-26844047	skin	malignant_melanoma	Substitution - Missense
c.1018G>T; p.E340*; 7:26670162-26670162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.384A>C; p.K128N; 7:26739888-26739888	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.362G>T; p.G121V; 7:26739910-26739910	skin	malignant_melanoma	Substitution - Missense
c.584G>A; p.R195H; 7:26726892-26726892	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.584G>A; p.R195H; 7:26726892-26726892	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.11C>T; p.P4L; 7:26864419-26864419	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1028G>A; p.G343E; 7:26670152-26670152	urinary_tract; bladder	carcinoma	Substitution - Missense
c.470-1G>T; p.?; 7:26727007-26727007	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.808G>T; p.D270Y; 7:26690351-26690351	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406G>C; p.E136Q; 7:26738858-26738858	breast	carcinoma	Substitution - Missense
c.949T>G; p.S317A; 7:26684774-26684774	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.727C>G; p.P243A; 7:26725497-26725497	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.473A>G; p.K158R; 7:26727003-26727003	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.377G>A; p.R126H; 7:26739895-26739895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.313C>T; p.Q105*; 7:26739959-26739959	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.30C>T; p.P10P; 7:26864400-26864400	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.423G>T; p.W141C; 7:26738841-26738841	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.162T>C; p.D54D; 7:26854796-26854796	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.641T>G; p.L214R; 7:26725940-26725940	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.583C>T; p.R195C; 7:26726893-26726893	thyroid	carcinoma	Substitution - Missense
c.418C>T; p.R140W; 7:26738846-26738846	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.418C>T; p.R140W; 7:26738846-26738846	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.577G>T; p.D193Y; 7:26726899-26726899	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.14G>A; p.S5N; 7:26864416-26864416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.678T>G; p.I226M; 7:26725546-26725546	skin; trunk	malignant_melanoma	Substitution - Missense
c.529C>T; p.L177L; 7:26726947-26726947	skin	malignant_melanoma	Substitution - coding silent
c.215G>T; p.G72V; 7:26844122-26844122	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.523A>T; p.N175Y; 7:26726953-26726953	skin	malignant_melanoma	Substitution - Missense
c.175T>C; p.Y59H; 7:26854161-26854161	skin	malignant_melanoma	Substitution - Missense
c.857G>A; p.S286N; 7:26690302-26690302	central_nervous_system; brain	glioma	Substitution - Missense
c.780T>G; p.I260M; 7:26725444-26725444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>T; p.D54Y; 7:26854798-26854798	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.59T>C; p.L20P; 7:26864371-26864371	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.376C>T; p.R126C; 7:26739896-26739896	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.376C>T; p.R126C; 7:26739896-26739896	skin; trunk	malignant_melanoma	Substitution - Missense
c.851A>G; p.Q284R; 7:26690308-26690308	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1013_1014delTA; p.V338fs*12; 7:26670166-26670167	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.664G>A; p.E222K; 7:26725560-26725560	skin	malignant_melanoma	Substitution - Missense
c.271G>A; p.E91K; 7:26844066-26844066	skin	malignant_melanoma	Substitution - Missense
c.235T>A; p.F79I; 7:26844102-26844102	NS	malignant_melanoma	Substitution - Missense
c.382A>G; p.K128E; 7:26739890-26739890	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.200-7_200-6delTT; p.?; 7:26844143-26844144	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.200-7_200-6delTT; p.?; 7:26844143-26844144	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.668C>T; p.S223F; 7:26725556-26725556	skin	malignant_melanoma	Substitution - Missense
c.820G>A; p.V274M; 7:26690339-26690339	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.849T>C; p.S283S; 7:26690310-26690310	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.682G>A; p.E228K; 7:26725542-26725542	breast	carcinoma	Substitution - Missense
c.140C>T; p.S47F; 7:26854818-26854818	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.948G>T; p.L316F; 7:26684775-26684775	pancreas	NS	Substitution - Missense
c.583C>G; p.R195G; 7:26726893-26726893	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.478C>T; p.Q160*; 7:26726998-26726998	skin	malignant_melanoma	Substitution - Nonsense
c.979C>A; p.L327I; 7:26684744-26684744	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718G>C; p.V240L; 7:26725506-26725506	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.805G>C; p.E269Q; 7:26690354-26690354	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.567C>A; p.I189I; 7:26726909-26726909	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.725A>T; p.H242L; 7:26725499-26725499	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1014A>G; p.V338V; 7:26670166-26670166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1009T>G; p.W337G; 7:26670171-26670171	liver	carcinoma	Substitution - Missense
c.1009T>G; p.W337G; 7:26670171-26670171	thyroid	other; neoplasm	Substitution - Missense
c.430C>T; p.L144F; 7:26738834-26738834	skin	malignant_melanoma	Substitution - Missense
c.353T>A; p.L118Q; 7:26739919-26739919	liver	carcinoma	Substitution - Missense
c.353T>A; p.L118Q; 7:26739919-26739919	liver	carcinoma	Substitution - Missense
c.201T>G; p.G67G; 7:26844136-26844136	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.201T>G; p.G67G; 7:26844136-26844136	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.938C>A; p.S313Y; 7:26684785-26684785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.734C>T; p.P245L; 7:26725490-26725490	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.V240I; 7:26725506-26725506	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.718G>A; p.V240I; 7:26725506-26725506	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.599C>T; p.T200I; 7:26725982-26725982	kidney	other; neoplasm	Substitution - Missense
c.1048A>G; p.K350E; 7:26670132-26670132	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.250G>T; p.D84Y; 7:26844087-26844087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.703G>T; p.E235*; 7:26725521-26725521	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.703G>T; p.E235*; 7:26725521-26725521	large_intestine; colon	carcinoma	Substitution - Nonsense
c.703G>T; p.E235*; 7:26725521-26725521	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.157A>C; p.K53Q; 7:26854801-26854801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.I345V; 7:26670147-26670147	liver	carcinoma	Substitution - Missense
c.1033A>G; p.I345V; 7:26670147-26670147	liver	carcinoma	Substitution - Missense
c.928G>A; p.G310R; 7:26684795-26684795	skin	malignant_melanoma	Substitution - Missense
c.772G>A; p.D258N; 7:26725452-26725452	skin; mucosal	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation