lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8836
Symbol	GGH
Synonymous	GH
Full name	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Gene description	gamma-Glu-X carboxypeptidase\|gamma-glutamyl hydrolase
Cytoband	8q12.3
Gene type	protein-coding
Synonymous	MIM:601509; HGNC:HGNC:4248; Ensembl:ENSG00000137563; HPRD:03299; Vega:OTTHUMG00000164365

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.284T>C; p.F95S; 8:63027257-63027257	skin	malignant_melanoma	Substitution - Missense
c.247T>A; p.Y83N; 8:63030195-63030195	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.790G>T; p.A264S; 8:63017538-63017538	pancreas	carcinoma	Substitution - Missense
c.616A>G; p.M206V; 8:63023988-63023988	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.D157D; 8:63026186-63026186	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.323C>G; p.A108G; 8:63027218-63027218	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.306C>G; p.L102L; 8:63027235-63027235	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.875A>T; p.E292V; 8:63015414-63015414	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.875A>T; p.E292V; 8:63015414-63015414	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>G; p.R53G; 8:63035723-63035723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.479T>C; p.M160T; 8:63026178-63026178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.E80E; 8:63030202-63030202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.248_249delAT; p.Y83fs*1; 8:63030193-63030194	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.834A>G; p.E278E; 8:63017494-63017494	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.600C>T; p.S200S; 8:63024086-63024086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.794T>C; p.V265A; 8:63017534-63017534	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.577A>G; p.N193D; 8:63024109-63024109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.883G>C; p.A295P; 8:63015406-63015406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.907A>T; p.I303F; 8:63015382-63015382	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.16T>C; p.C6R; 8:63038753-63038753	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.16T>C; p.C6R; 8:63038753-63038753	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.16T>C; p.C6R; 8:63038753-63038753	thyroid	other; neoplasm	Substitution - Missense
c.16T>C; p.C6R; 8:63038753-63038753	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.891T>G; p.I297M; 8:63015398-63015398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.408delA; p.F137fs*7; 8:63026249-63026249	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.92C>T; p.A31V; 8:63038677-63038677	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.74G>A; p.R25K; 8:63038695-63038695	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.A31T; 8:63038678-63038678	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.A31T; 8:63038678-63038678	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.A31T; 8:63038678-63038678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.A31T; 8:63038678-63038678	urinary_tract; bladder	carcinoma	Substitution - Missense
c.91G>A; p.A31T; 8:63038678-63038678	thyroid	other; neoplasm	Substitution - Missense
c.387_388insC; p.V130fs*9; 8:63026269-63026270	liver	carcinoma	Insertion - Frameshift
c.35G>A; p.G12D; 8:63038734-63038734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>T; p.G97*; 8:63027252-63027252	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.929C>T; p.S310L; 8:63015360-63015360	skin	malignant_melanoma	Substitution - Missense
c.836-8delT; p.?; 8:63015461-63015461	stomach	adenocarcinoma	Unknown
c.763T>C; p.L255L; 8:63017565-63017565	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.797A>G; p.K266R; 8:63017531-63017531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.705G>A; p.K235K; 8:63017623-63017623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.482C>T; p.P161L; 8:63026175-63026175	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.174G>A; p.A58A; 8:63035706-63035706	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.507G>T; p.L169F; 8:63024179-63024179	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.452C>T; p.T151I; 8:63026205-63026205	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>T; p.T151I; 8:63026205-63026205	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.449T>C; p.L150S; 8:63026208-63026208	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.502C>G; p.Q168E; 8:63024184-63024184	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.98A>T; p.K33M; 8:63038671-63038671	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.98A>T; p.K33M; 8:63038671-63038671	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.184A>T; p.K62*; 8:63035696-63035696	skin; mucosal	malignant_melanoma	Substitution - Nonsense
c.140T>C; p.V47A; 8:63035740-63035740	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.902G>T; p.S301I; 8:63015387-63015387	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.874G>T; p.E292*; 8:63015415-63015415	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.460G>A; p.D154N; 8:63026197-63026197	breast	carcinoma	Substitution - Missense
c.873A>C; p.E291D; 8:63015416-63015416	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.873A>C; p.E291D; 8:63015416-63015416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.275+9G>A; p.?; 8:63030158-63030158	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.173C>T; p.A58V; 8:63035707-63035707	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.S118F; 8:63027188-63027188	skin	malignant_melanoma	Substitution - Missense
c.221T>C; p.V74A; 8:63035659-63035659	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.310C>T; p.R104C; 8:63027231-63027231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.879G>A; p.E293E; 8:63015410-63015410	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.310C>T; p.R104C; 8:63027231-63027231	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>T; p.A108V; 8:63027218-63027218	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>T; p.A108V; 8:63027218-63027218	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>T; p.A108V; 8:63027218-63027218	large_intestine; colon	carcinoma	Substitution - Missense
c.323C>T; p.A108V; 8:63027218-63027218	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.751G>A; p.E251K; 8:63017577-63017577	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.911A>T; p.Y304F; 8:63015378-63015378	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.S59S; 8:63035703-63035703	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation