lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8751
Symbol	ADAM15
Synonymous	MDC15
Full name	ADAM metallopeptidase domain 15
Gene description	MDC-15\|a disintegrin and metalloproteinase domain 15 (metargidin)\|disintegrin and metalloproteinase domain-containing protein 15\|metalloprotease RGD disintegrin protein\|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Cytoband	1q21.3
Gene type	protein-coding
Synonymous	MIM:605548; HGNC:HGNC:193; Ensembl:ENSG00000143537; HPRD:05674; Vega:OTTHUMG00000013898

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1564G>A; p.G522R; 1:155057998-155057998	urinary_tract; bladder	carcinoma	Substitution - Missense
c.87T>C; p.T29T; 1:155052678-155052678	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1752G>T; p.Q584H; 1:155058276-155058276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1143C>T; p.S381S; 1:155057096-155057096	skin	malignant_melanoma	Substitution - coding silent
c.1297G>A; p.E433K; 1:155057336-155057336	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.281G>A; p.R94H; 1:155053927-155053927	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1617C>A; p.A539A; 1:155058051-155058051	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1161C>T; p.G387G; 1:155057200-155057200	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1575C>T; p.A525A; 1:155058009-155058009	skin	malignant_melanoma	Substitution - coding silent
c.1624G>A; p.A542T; 1:155058058-155058058	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2277G>A; p.K759K; 1:155060832-155060832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.514C>A; p.L172I; 1:155054408-155054408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.747C>A; p.F249L; 1:155056082-155056082	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.212T>C; p.I71T; 1:155053442-155053442	NS	NS	Substitution - Missense
c.1177T>A; p.C393S; 1:155057216-155057216	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.569A>T; p.Q190L; 1:155054463-155054463	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808C>T; p.L270L; 1:155056143-155056143	skin	malignant_melanoma	Substitution - coding silent
c.586C>T; p.P196S; 1:155054480-155054480	skin	malignant_melanoma	Substitution - Missense
c.985G>A; p.G329R; 1:155056456-155056456	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1623C>T; p.P541P; 1:155058057-155058057	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1623C>T; p.P541P; 1:155058057-155058057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.482A>G; p.Q161R; 1:155054376-155054376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.482A>G; p.Q161R; 1:155054376-155054376	thyroid	carcinoma	Substitution - Missense
c.2194A>C; p.T732P; 1:155060330-155060330	thyroid	other; neoplasm	Substitution - Missense
c.1333G>A; p.D445N; 1:155057646-155057646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1333G>A; p.D445N; 1:155057646-155057646	skin	malignant_melanoma	Substitution - Missense
c.1456G>A; p.D486N; 1:155057890-155057890	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2466G>A; p.L822L; 1:155062286-155062286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.100G>A; p.A34T; 1:155052691-155052691	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1744C>T; p.Q582*; 1:155058268-155058268	skin	malignant_melanoma	Substitution - Nonsense
c.914C>T; p.T305I; 1:155056249-155056249	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.914C>T; p.T305I; 1:155056249-155056249	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.914C>T; p.T305I; 1:155056249-155056249	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.2255C>T; p.A752V; 1:155060810-155060810	skin	malignant_melanoma	Substitution - Missense
c.2421G>A; p.P807P; 1:155061972-155061972	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2263G>A; p.A755T; 1:155060818-155060818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>A; p.E282K; 1:155056179-155056179	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.47G>T; p.S16I; 1:155051433-155051433	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.336C>A; p.H112Q; 1:155053982-155053982	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1429G>T; p.G477C; 1:155057863-155057863	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1523A>G; p.D508G; 1:155057957-155057957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.955C>G; p.Q319E; 1:155056426-155056426	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.362delG; p.G121fs*25; 1:155054169-155054169	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Deletion - Frameshift
c.539C>T; p.A180V; 1:155054433-155054433	skin; trunk	malignant_melanoma	Substitution - Missense
c.2495C>T; p.S832L; 1:155062315-155062315	oesophagus	carcinoma	Substitution - Missense
c.501G>T; p.S167S; 1:155054395-155054395	breast	carcinoma	Substitution - coding silent
c.518A>C; p.H173P; 1:155054412-155054412	breast	carcinoma	Substitution - Missense
c.1406A>G; p.Q469R; 1:155057719-155057719	skin	malignant_melanoma	Substitution - Missense
c.626T>C; p.V209A; 1:155055803-155055803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1205T>C; p.L402P; 1:155057244-155057244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1972C>T; p.R658*; 1:155058764-155058764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.611G>A; p.R204Q; 1:155054505-155054505	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.979T>G; p.F327V; 1:155056450-155056450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747C>T; p.F249F; 1:155056082-155056082	skin	malignant_melanoma	Substitution - coding silent
c.747C>T; p.F249F; 1:155056082-155056082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>T; p.A39A; 1:155052708-155052708	skin	malignant_melanoma	Substitution - coding silent
c.2371C>T; p.P791S; 1:155061922-155061922	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.616C>T; p.R206W; 1:155055793-155055793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1015A>G; p.I339V; 1:155056968-155056968	pancreas	carcinoma	Substitution - Missense
c.2527C>T; p.P843S; 1:155062347-155062347	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.999G>A; p.M333I; 1:155056470-155056470	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1258A>G; p.M420V; 1:155057297-155057297	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.N276N; 1:155056163-155056163	skin	malignant_melanoma	Substitution - coding silent
c.1687A>C; p.N563H; 1:155058121-155058121	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1527C>T; p.G509G; 1:155057961-155057961	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1527C>T; p.G509G; 1:155057961-155057961	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.754C>T; p.P252S; 1:155056089-155056089	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.86C>T; p.T29I; 1:155052677-155052677	thyroid	other; neoplasm	Substitution - Missense
c.79G>A; p.G27S; 1:155051465-155051465	skin	malignant_melanoma	Substitution - Missense
c.503G>A; p.R168Q; 1:155054397-155054397	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.446G>T; p.R149I; 1:155054340-155054340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2552C>T; p.P851L; 1:155062462-155062462	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2558C>A; p.P853Q; 1:155062468-155062468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1238G>A; p.R413Q; 1:155057277-155057277	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1792C>G; p.L598V; 1:155058316-155058316	breast	carcinoma	Substitution - Missense
c.2485C>T; p.R829W; 1:155062305-155062305	liver	carcinoma	Substitution - Missense
c.2485C>T; p.R829W; 1:155062305-155062305	liver	carcinoma	Substitution - Missense
c.852C>T; p.F284F; 1:155056187-155056187	thyroid	carcinoma	Substitution - coding silent
c.1204C>T; p.L402F; 1:155057243-155057243	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2045C>T; p.P682L; 1:155059951-155059951	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.93G>A; p.E31E; 1:155052684-155052684	pancreas	carcinoma	Substitution - coding silent
c.669C>T; p.H223H; 1:155055846-155055846	skin	malignant_melanoma	Substitution - coding silent
c.1423C>A; p.P475T; 1:155057857-155057857	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1227C>T; p.C409C; 1:155057266-155057266	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1528G>A; p.E510K; 1:155057962-155057962	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1933C>T; p.R645*; 1:155058725-155058725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2481G>T; p.Q827H; 1:155062301-155062301	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.538G>T; p.A180S; 1:155054432-155054432	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.437C>T; p.T146I; 1:155054331-155054331	skin	malignant_melanoma	Substitution - Missense
c.636C>G; p.T212T; 1:155055813-155055813	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1609C>T; p.P537S; 1:155058043-155058043	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2302_2303insC; p.S771fs*7; 1:155061439-155061440	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2305C>T; p.P769S; 1:155061442-155061442	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1752G>A; p.Q584Q; 1:155058276-155058276	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2305C>T; p.P769S; 1:155061442-155061442	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.125A>G; p.E42G; 1:155052716-155052716	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.375_376insAT; p.Y126fs*21; 1:155054182-155054183	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1254C>A; p.P418P; 1:155057293-155057293	breast	carcinoma	Substitution - coding silent
c.1018C>T; p.L340L; 1:155056971-155056971	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2450C>T; p.P817L; 1:155062270-155062270	NS	malignant_melanoma	Substitution - Missense
c.1113C>T; p.A371A; 1:155057066-155057066	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1942C>T; p.R648C; 1:155058734-155058734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1214G>A; p.G405E; 1:155057253-155057253	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.306C>T; p.P102P; 1:155053952-155053952	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1118C>T; p.A373V; 1:155057071-155057071	thyroid	carcinoma	Substitution - Missense
c.2141G>T; p.S714I; 1:155060277-155060277	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2134G>A; p.G712S; 1:155060270-155060270	breast	carcinoma	Substitution - Missense
c.2138C>T; p.A713V; 1:155060274-155060274	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2362G>A; p.A788T; 1:155061913-155061913	skin; trunk	malignant_melanoma	Substitution - Missense
c.2433G>A; p.G811G; 1:155062253-155062253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1141T>C; p.S381P; 1:155057094-155057094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1873C>A; p.Q625K; 1:155058397-155058397	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.883C>G; p.R295G; 1:155056218-155056218	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1044T>C; p.H348H; 1:155056997-155056997	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>A; p.L402L; 1:155057245-155057245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1223_1225delGCT; p.C409delC; 1:155057262-155057264	breast	carcinoma	Deletion - In frame
c.1261G>T; p.A421S; 1:155057300-155057300	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1787G>A; p.R596Q; 1:155058311-155058311	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1554G>T; p.V518V; 1:155057988-155057988	prostate	carcinoma	Substitution - coding silent
c.1698C>T; p.G566G; 1:155058132-155058132	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2303delC; p.P770fs*35; 1:155061440-155061440	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1504C>T; p.P502S; 1:155057938-155057938	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>T; p.S224L; 1:155055848-155055848	skin	malignant_melanoma	Substitution - Missense
c.1254C>T; p.P418P; 1:155057293-155057293	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.345G>A; p.E115E; 1:155054152-155054152	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.743C>T; p.T248I; 1:155055999-155055999	breast	carcinoma	Substitution - Missense
c.2196C>T; p.T732T; 1:155060332-155060332	skin	malignant_melanoma	Substitution - coding silent
c.423C>A; p.G141G; 1:155054317-155054317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2221G>T; p.G741C; 1:155060776-155060776	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.766C>T; p.R256*; 1:155056101-155056101	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2205C>T; p.Y735Y; 1:155060341-155060341	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.299A>G; p.Y100C; 1:155053945-155053945	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.111G>T; p.E37D; 1:155052702-155052702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.784C>A; p.L262M; 1:155056119-155056119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2512C>A; p.P838T; 1:155062332-155062332	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2333C>A; p.P778H; 1:155061470-155061470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1010C>T; p.T337I; 1:155056963-155056963	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1147G>A; p.D383N; 1:155057100-155057100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1739A>C; p.Q580P; 1:155058263-155058263	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1628C>T; p.A543V; 1:155058062-155058062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1433G>T; p.W478L; 1:155057867-155057867	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2219C>T; p.S740F; 1:155060774-155060774	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1329C>T; p.C443C; 1:155057642-155057642	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329C>T; p.C443C; 1:155057642-155057642	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1273G>A; p.G425R; 1:155057312-155057312	liver	carcinoma	Substitution - Missense
c.1273G>A; p.G425R; 1:155057312-155057312	liver	carcinoma	Substitution - Missense
c.1445C>T; p.P482L; 1:155057879-155057879	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.412G>T; p.G138W; 1:155054219-155054219	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.412G>T; p.G138W; 1:155054219-155054219	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1497G>A; p.Q499Q; 1:155057931-155057931	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2207+1G>A; p.?; 1:155060344-155060344	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2420C>G; p.P807R; 1:155061971-155061971	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1237C>T; p.R413W; 1:155057276-155057276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1771C>G; p.L591V; 1:155058295-155058295	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.863G>A; p.R288H; 1:155056198-155056198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2150A>T; p.Y717F; 1:155060286-155060286	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.378T>C; p.Y126Y; 1:155054185-155054185	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215A>C; p.G405G; 1:155057254-155057254	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation