Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8744
Symbol

TNFSF9

Synonymous

4-1BB-L|CD137L

Full name

tumor necrosis factor (ligand) superfamily, member 9

Gene description

4-1BB ligand|4-1BBL|homolog of mouse 4-1BB-L|receptor 4-1BB ligand|tumor necrosis factor ligand superfamily member 9

Cytoband

19p13.3

Gene type

protein-coding

Synonymous

MIM:606182; HGNC:HGNC:11939; Ensembl:ENSG00000125657; HPRD:05861; Vega:OTTHUMG00000181831

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.727G>A; p.E243K; 19:6535028-6535028

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.316C>T; p.P106S; 19:6534617-6534617

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.715C>T; p.R239W; 19:6535016-6535016

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.347C>T; p.A116V; 19:6534648-6534648

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.642C>T; p.V214V; 19:6534943-6534943

 skinmalignant_melanomaSubstitution - coding silent

c.716G>A; p.R239Q; 19:6535017-6535017

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.512G>A; p.R171H; 19:6534813-6534813

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.504G>T; p.Q168H; 19:6534805-6534805

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.504G>T; p.Q168H; 19:6534805-6534805

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.504G>T; p.Q168H; 19:6534805-6534805

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.504G>T; p.Q168H; 19:6534805-6534805

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.562G>A; p.A188T; 19:6534863-6534863

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.591C>G; p.F197L; 19:6534892-6534892

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.711C>T; p.L237L; 19:6535012-6535012

 livercarcinomaSubstitution - coding silent

c.745C>T; p.P249S; 19:6535046-6535046

 skinmalignant_melanomaSubstitution - Missense

c.745C>T; p.P249S; 19:6535046-6535046

 skinmalignant_melanomaSubstitution - Missense

c.669C>A; p.R223R; 19:6534970-6534970

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.669C>A; p.R223R; 19:6534970-6534970

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.727G>C; p.E243Q; 19:6535028-6535028

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.150C>A; p.A50A; 19:6531186-6531186

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.752C>T; p.P251L; 19:6535053-6535053

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.71G>A; p.C24Y; 19:6531107-6531107

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.739G>T; p.G247*; 19:6535040-6535040

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.591C>T; p.F197F; 19:6534892-6534892

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.343C>A; p.L115M; 19:6534644-6534644

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.521C>A; p.A174D; 19:6534822-6534822

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.759G>A; p.S253S; 19:6535060-6535060

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.759G>A; p.S253S; 19:6535060-6535060

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - coding silent

c.3G>A; p.M1I; 19:6531039-6531039

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.732C>T; p.I244I; 19:6535033-6535033

 skinmalignant_melanomaSubstitution - coding silent

c.310G>C; p.D104H; 19:6534611-6534611

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.690G>A; p.Q230Q; 19:6534991-6534991

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.390G>A; p.T130T; 19:6534691-6534691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.638G>A; p.G213D; 19:6534939-6534939

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.400G>A; p.V134M; 19:6534701-6534701

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.102_107delGCTGCT; p.L40_L41delLL; 19:6531138-6531143

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; angioimmunoblastic_T_cell_lymphomaDeletion - In frame

c.58C>T; p.R20C; 19:6531094-6531094

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.389C>T; p.T130M; 19:6534690-6534690

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.18C>T; p.D6D; 19:6531054-6531054

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.578G>A; p.R193Q; 19:6534879-6534879

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.357C>T; p.S119S; 19:6534658-6534658

 skinmalignant_melanomaSubstitution - coding silent

c.123C>T; p.L41L; 19:6531159-6531159

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.418G>A; p.V140I; 19:6534719-6534719

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.694G>A; p.A232T; 19:6534995-6534995

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.694G>A; p.A232T; 19:6534995-6534995

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.451C>T; p.R151C; 19:6534752-6534752

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.363delG; p.G123fs*2; 19:6534664-6534664

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.370C>G; p.L124V; 19:6534671-6534671

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.693C>T; p.G231G; 19:6534994-6534994

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.693C>T; p.G231G; 19:6534994-6534994

 prostatecarcinomaSubstitution - coding silent

c.267+2T>C; p.?; 19:6531305-6531305

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.426delT; p.Y142fs*1; 19:6534727-6534727

 skin; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.591C>A; p.F197L; 19:6534892-6534892

 livercarcinomaSubstitution - Missense

c.23C>T; p.S8L; 19:6531059-6531059

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.591C>A; p.F197L; 19:6534892-6534892

 livercarcinomaSubstitution - Missense

c.624C>T; p.A208A; 19:6534925-6534925

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.102_104delGCT; p.L41delL; 19:6531138-6531140

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - In frame

c.102_104delGCT; p.L41delL; 19:6531138-6531140

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.102_104delGCT; p.L41delL; 19:6531138-6531140

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; angioimmunoblastic_T_cell_lymphomaDeletion - In frame