Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8692
Symbol

HYAL2

Synonymous

LUCA2

Full name

hyaluronoglucosaminidase 2

Gene description

PH-20 homolog|PH20 homolog|hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2|lung carcinoma protein 2|lysosomal hyaluronidase

Cytoband

3p21.3

Gene type

protein-coding

Synonymous

MIM:603551; HGNC:HGNC:5321; Ensembl:ENSG00000068001; HPRD:04649; Vega:OTTHUMG00000156876

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.135_136GG>AA; p.D46N; 3:50320354-50320355

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.986delG; p.G329fs*19; 3:50318981-50318981

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1184G>A; p.R395H; 3:50318367-50318367

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.244C>T; p.R82C; 3:50320246-50320246

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.441C>T; p.D147D; 3:50320049-50320049

 prostatecarcinomaSubstitution - coding silent

c.1351G>A; p.E451K; 3:50318200-50318200

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1259A>G; p.H420R; 3:50318292-50318292

 livercarcinomaSubstitution - Missense

c.1259A>G; p.H420R; 3:50318292-50318292

 livercarcinomaSubstitution - Missense

c.255G>C; p.L85L; 3:50320235-50320235

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.851C>G; p.A284G; 3:50319639-50319639

 breastcarcinomaSubstitution - Missense

c.46_47insG; p.A16fs*46; 3:50320443-50320444

 endometriumcarcinoma; endometrioid_carcinomaInsertion - Frameshift

c.1216_1217insC; p.Q406fs*14; 3:50318334-50318335

 livercarcinomaInsertion - Frameshift

c.574C>T; p.R192C; 3:50319916-50319916

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1169G>A; p.S390N; 3:50318382-50318382

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.593G>T; p.R198L; 3:50319897-50319897

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.268G>A; p.D90N; 3:50320222-50320222

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.428G>A; p.R143H; 3:50320062-50320062

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.543C>T; p.F181F; 3:50319947-50319947

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1039C>T; p.L347L; 3:50318512-50318512

 skinmalignant_melanomaSubstitution - coding silent

c.1349G>T; p.S450I; 3:50318202-50318202

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.388G>A; p.A130T; 3:50320102-50320102

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.171G>C; p.L57L; 3:50320319-50320319

 breastcarcinomaSubstitution - coding silent

c.979C>T; p.L327F; 3:50318988-50318988

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.59C>T; p.A20V; 3:50320431-50320431

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.281G>C; p.R94T; 3:50320209-50320209

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.953C>T; p.A318V; 3:50319014-50319014

 ovaryother; neoplasmSubstitution - Missense

c.953C>T; p.A318V; 3:50319014-50319014

 ovaryother; neoplasmSubstitution - Missense

c.708C>T; p.D236D; 3:50319782-50319782

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.192C>G; p.A64A; 3:50320298-50320298

 kidneyother; neoplasmSubstitution - coding silent

c.909G>T; p.T303T; 3:50319581-50319581

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.909G>T; p.T303T; 3:50319581-50319581

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.909G>T; p.T303T; 3:50319581-50319581

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.255G>A; p.L85L; 3:50320235-50320235

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1000A>G; p.T334A; 3:50318967-50318967

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.267C>T; p.F89F; 3:50320223-50320223

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.738G>A; p.T246T; 3:50319752-50319752

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.267C>T; p.F89F; 3:50320223-50320223

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.267C>T; p.F89F; 3:50320223-50320223

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1252A>C; p.I418L; 3:50318299-50318299

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.961G>A; p.G321S; 3:50319006-50319006

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.573G>A; p.L191L; 3:50319917-50319917

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.454C>T; p.R152C; 3:50320036-50320036

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.48G>T; p.A16A; 3:50320442-50320442

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1264C>T; p.Q422*; 3:50318287-50318287

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1362T>C; p.A454A; 3:50318189-50318189

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.685G>A; p.D229N; 3:50319805-50319805

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1233G>A; p.G411G; 3:50318318-50318318

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1046G>A; p.R349Q; 3:50318505-50318505

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.406G>T; p.D136Y; 3:50320084-50320084

 breastcarcinomaSubstitution - Missense

c.321G>A; p.W107*; 3:50320169-50320169

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.52T>G; p.S18A; 3:50320438-50320438

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.52T>G; p.S18A; 3:50320438-50320438

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1153A>G; p.T385A; 3:50318398-50318398

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1058C>T; p.P353L; 3:50318493-50318493

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1394C>T; p.A465V; 3:50318157-50318157

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1158C>T; p.F386F; 3:50318393-50318393

 skinmalignant_melanomaSubstitution - coding silent

c.346C>T; p.R116C; 3:50320144-50320144

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1272C>A; p.H424Q; 3:50318279-50318279

 ovaryother; neoplasmSubstitution - Missense

c.665G>T; p.S222I; 3:50319825-50319825

 breastcarcinomaSubstitution - Missense

c.600G>A; p.R200R; 3:50319890-50319890

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.600G>A; p.R200R; 3:50319890-50319890

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.829C>T; p.R277C; 3:50319661-50319661

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.330G>A; p.R110R; 3:50320160-50320160

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.796A>G; p.N266D; 3:50319694-50319694

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1010C>T; p.T337M; 3:50318957-50318957

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.748C>T; p.P250S; 3:50319742-50319742

 skinmalignant_melanomaSubstitution - Missense

c.1132C>T; p.R378C; 3:50318419-50318419

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1304G>A; p.G435D; 3:50318247-50318247

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.464C>A; p.S155*; 3:50320026-50320026

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.785G>A; p.R262H; 3:50319705-50319705

 stomachcarcinoma; adenocarcinomaSubstitution - Missense