Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8651
Symbol

SOCS1

Synonymous

CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3

Full name

suppressor of cytokine signaling 1

Gene description

JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1

Cytoband

16p13.13

Gene type

protein-coding

Synonymous

MIM:603597; HGNC:HGNC:19383; Ensembl:ENSG00000185338; HPRD:04669; Vega:OTTHUMG00000129792

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.314A>C; p.D105A; 16:11255165-11255165

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.227C>T; p.A76V; 16:11255252-11255252

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.379C>T; p.R127C; 16:11255100-11255100

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.379C>T; p.R127C; 16:11255100-11255100

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.614G>A; p.S205N; 16:11254865-11254865

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.353_367del15; p.K118_P123>T; 16:11255112-11255126

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaComplex - deletion inframe

c.343_349delCTTAGCG; p.L115fs*1; 16:11255130-11255136

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.435_448>GG; p.D145_L150>EV; 16:11255031-11255044

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaComplex - deletion inframe

c.192_541del350; p.Y64fs*1; 16:11254938-11255287

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.193_203del11; p.R65fs*48; 16:11255276-11255286

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.203C>T; p.T68M; 16:11255276-11255276

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - Missense

c.342C>T; p.A114A; 16:11255137-11255137

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.318_377del60; p.R107_I126del; 16:11255102-11255161

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.388_402del15; p.F130_R134del; 16:11255077-11255091

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - In frame

c.616T>C; p.S206P; 16:11254863-11254863

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.622C>T; p.P208S; 16:11254857-11254857

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.260A>G; p.H87R; 16:11255219-11255219

 pancreascarcinomaSubstitution - Missense

c.195G>A; p.R65R; 16:11255284-11255284

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.195G>A; p.R65R; 16:11255284-11255284

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.195G>A; p.R65R; 16:11255284-11255284

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.479G>A; p.R160H; 16:11255000-11255000

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.297C>A; p.G99G; 16:11255182-11255182

 central_nervous_system; braingliomaSubstitution - coding silent

c.358G>A; p.A120T; 16:11255121-11255121

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.358G>A; p.A120T; 16:11255121-11255121

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.541C>T; p.R181C; 16:11254938-11254938

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.541C>T; p.R181C; 16:11254938-11254938

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.236_237ins39; p.F79_Y80ins13; 16:11255242-11255243

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaInsertion - In frame

c.108_171del64; p.A37fs*27; 16:11255308-11255371

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.108_171del64; p.A37fs*27; 16:11255308-11255371

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.528G>A; p.E176E; 16:11254951-11254951

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.526_533delGAGCTGTG; p.E176fs*35; 16:11254946-11254953

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.526_533delGAGCTGTG; p.E176fs*35; 16:11254946-11254953

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.526_533delGAGCTGTG; p.E176fs*35; 16:11254946-11254953

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.190T>A; p.Y64N; 16:11255289-11255289

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.186_323del138; p.D63_Q108del; 16:11255156-11255293

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.511_537del27; p.V171_R179del; 16:11254942-11254968

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.534C>G; p.C178W; 16:11254945-11254945

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.208_257del50; p.S71fs*29; 16:11255222-11255271

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.491_492insG; p.L166fs*>47; 16:11254987-11254988

 skin; head_neckcarcinoma; squamous_cell_carcinomaInsertion - Frameshift

c.356T>C; p.M119T; 16:11255123-11255123

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.372G>A; p.T124T; 16:11255107-11255107

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.?; p.?; 16:11255480-11255480

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaUnknown

c.318C>G; p.S106R; 16:11255161-11255161

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.345T>G; p.L115L; 16:11255134-11255134

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.191_218del28; p.Y64fs*12; 16:11255261-11255288

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.145_149delGCCCC; p.A49fs*66; 16:11255330-11255334

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; myelofibrosisDeletion - Frameshift

c.83C>T; p.S28F; 16:11255396-11255396

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.18G>C; p.Q6H; 16:11255461-11255461

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.431_512del82; p.F144fs*34; 16:11254967-11255048

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.236T>G; p.F79C; 16:11255243-11255243

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.80C>T; p.S27F; 16:11255399-11255399

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; plasmacytomaSubstitution - Missense

c.177_195del19; p.S60fs*19; 16:11255284-11255302

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.46G>C; p.A16P; 16:11255433-11255433

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.495_502delGCTGCGCC; p.L166fs*45; 16:11254977-11254984

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.454_464del11; p.E152fs*58; 16:11255015-11255025

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.454_464del11; p.E152fs*58; 16:11255015-11255025

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.404T>G; p.F135C; 16:11255075-11255075

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.483_489delGCTGGGG; p.L162fs*41; 16:11254990-11254996

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.46G>A; p.A16T; 16:11255433-11255433

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.630G>C; p.Q210H; 16:11254849-11254849

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.46G>A; p.A16T; 16:11255433-11255433

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.46G>A; p.A16T; 16:11255433-11255433

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.621C>T; p.F207F; 16:11254858-11254858

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.630G>C; p.Q210H; 16:11254849-11254849

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.630G>C; p.Q210H; 16:11254849-11254849

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.197G>C; p.R66P; 16:11255282-11255282

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.347G>A; p.S116N; 16:11255132-11255132

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.265G>A; p.A89T; 16:11255214-11255214

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.348C>A; p.S116R; 16:11255131-11255131

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.490delG; p.A164fs*41; 16:11254989-11254989

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaDeletion - Frameshift

c.241T>A; p.W81R; 16:11255238-11255238

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.617C>A; p.S206Y; 16:11254862-11254862

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.190_200del11; p.Y64fs*49; 16:11255279-11255289

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.?; p.?; 16:11254783-11254784

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaUnknown

c.7G>A; p.A3T; 16:11255472-11255472

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.393_407del15; p.Q131_H136>H; 16:11255072-11255086

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - In frame

c.7G>A; p.A3T; 16:11255472-11255472

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.391C>A; p.Q131K; 16:11255088-11255088

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Burkitt_lymphomaSubstitution - Missense

c.379_636del258; p.R127_*212del; 16:11254843-11255100

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.636+24A>G; p.?; 16:11254819-11254819

 breastcarcinomaUnknown

c.240C>G; p.Y80*; 16:11255239-11255239

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Nonsense

c.4G>A; p.V2I; 16:11255475-11255475

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.150_166del17; p.G51fs*60; 16:11255313-11255329

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.384G>A; p.V128V; 16:11255095-11255095

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - coding silent

c.14A>G; p.N5S; 16:11255465-11255465

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.99C>T; p.P33P; 16:11255380-11255380

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.127C>T; p.P43S; 16:11255352-11255352

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.99C>T; p.P33P; 16:11255380-11255380

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.349_359del11; p.V117fs*93; 16:11255120-11255130

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.349_359del11; p.V117fs*93; 16:11255120-11255130

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphomaDeletion - Frameshift

c.360C>T; p.A120A; 16:11255119-11255119

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.592C>T; p.P198S; 16:11254887-11254887

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.592C>T; p.P198S; 16:11254887-11254887

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia_associated_with_MDSSubstitution - Missense

c.471_482del12; p.P158_M161del; 16:11254997-11255008

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.602G>A; p.R201H; 16:11254877-11254877

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.552_575del24; p.A184_L191del; 16:11254904-11254927

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.552_575del24; p.A184_L191del; 16:11254904-11254927

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - In frame

c.184G>C; p.A62P; 16:11255295-11255295

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.49G>A; p.A17T; 16:11255430-11255430

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.49G>A; p.A17T; 16:11255430-11255430

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.216_225del10; p.L73fs*9; 16:11255254-11255263

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphomaDeletion - Frameshift

c.603C>T; p.R201R; 16:11254876-11254876

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.16C>T; p.Q6*; 16:11255463-11255463

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Nonsense