lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8613
Symbol	PPAP2B
Synonymous	Dri42\|LPP3\|PAP2B\|VCIP
Full name	phosphatidic acid phosphatase type 2B
Gene description	PAP2 beta\|lipid phosphate phosphohydrolase 3\|phosphatidate phosphohydrolase type 2b\|type-2 phosphatidic acid phosphatase-beta\|vascular endothelial growth factor and type I collagen inducible
Cytoband	1p32.2
Gene type	protein-coding
Synonymous	MIM:607125; HGNC:HGNC:9229; Ensembl:ENSG00000162407; HPRD:06179; Vega:OTTHUMG00000008160

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.353T>A; p.I118N; 1:56524499-56524499	liver	carcinoma	Substitution - Missense
c.353T>A; p.I118N; 1:56524499-56524499	liver	carcinoma	Substitution - Missense
c.454G>T; p.G152W; 1:56524398-56524398	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.819C>T; p.F273F; 1:56496668-56496668	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.457C>T; p.R153C; 1:56524395-56524395	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:56524395-56524395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.730T>G; p.S244A; 1:56512056-56512056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:56524395-56524395	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.R153C; 1:56524395-56524395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.350C>T; p.T117M; 1:56524502-56524502	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.575G>T; p.R192M; 1:56524277-56524277	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.880G>A; p.E294K; 1:56496607-56496607	skin	malignant_melanoma	Substitution - Missense
c.764A>G; p.D255G; 1:56512022-56512022	skin	malignant_melanoma	Substitution - Missense
c.880G>A; p.E294K; 1:56496607-56496607	skin	malignant_melanoma	Substitution - Missense
c.50G>C; p.G17A; 1:56578967-56578967	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.297G>A; p.A99A; 1:56536955-56536955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.297G>A; p.A99A; 1:56536955-56536955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.297G>A; p.A99A; 1:56536955-56536955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.680G>T; p.R227L; 1:56512106-56512106	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.733C>T; p.R245C; 1:56512053-56512053	skin	malignant_melanoma	Substitution - Missense
c.733C>T; p.R245C; 1:56512053-56512053	skin	malignant_melanoma	Substitution - Missense
c.733C>T; p.R245C; 1:56512053-56512053	skin	malignant_melanoma	Substitution - Missense
c.336G>T; p.K112N; 1:56524516-56524516	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.360C>T; p.N120N; 1:56524492-56524492	skin	malignant_melanoma	Substitution - coding silent
c.261G>A; p.V87V; 1:56536991-56536991	liver	carcinoma	Substitution - coding silent
c.576G>A; p.R192R; 1:56523880-56523880	skin	malignant_melanoma	Substitution - coding silent
c.581C>T; p.S194F; 1:56523875-56523875	skin	malignant_melanoma	Substitution - Missense
c.585C>A; p.F195L; 1:56523871-56523871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.379T>A; p.Y127N; 1:56524473-56524473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.321G>A; p.R107R; 1:56524531-56524531	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.310G>A; p.E104K; 1:56524542-56524542	skin	malignant_melanoma	Substitution - Missense
c.477G>A; p.L159L; 1:56524375-56524375	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.279C>T; p.I93I; 1:56536973-56536973	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.294C>T; p.L98L; 1:56536958-56536958	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.890C>T; p.S297L; 1:56496597-56496597	skin	malignant_melanoma	Substitution - Missense
c.745C>T; p.H249Y; 1:56512041-56512041	skin	malignant_melanoma	Substitution - Missense
c.343C>T; p.R115W; 1:56524509-56524509	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.633G>C; p.V211V; 1:56523823-56523823	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.305C>T; p.T102M; 1:56524547-56524547	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.181C>T; p.P61S; 1:56537071-56537071	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.517G>A; p.E173K; 1:56524335-56524335	urinary_tract; bladder	carcinoma	Substitution - Missense
c.874C>T; p.R292W; 1:56496613-56496613	skin	malignant_melanoma	Substitution - Missense
c.400C>A; p.L134I; 1:56524452-56524452	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.814T>C; p.F272L; 1:56496673-56496673	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.874C>T; p.R292W; 1:56496613-56496613	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.191G>A; p.R64Q; 1:56537061-56537061	skin	malignant_melanoma	Substitution - Missense
c.458G>A; p.R153H; 1:56524394-56524394	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.191G>A; p.R64Q; 1:56537061-56537061	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.208G>A; p.D70N; 1:56537044-56537044	skin	malignant_melanoma	Substitution - Missense
c.503A>T; p.Q168L; 1:56524349-56524349	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.662G>A; p.R221Q; 1:56512124-56512124	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.754C>A; p.H252N; 1:56512032-56512032	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.705C>T; p.I235I; 1:56512081-56512081	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.841A>T; p.K281*; 1:56496646-56496646	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.207T>A; p.N69K; 1:56537045-56537045	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>G; p.I59M; 1:56537075-56537075	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.642G>C; p.L214L; 1:56512144-56512144	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.264C>T; p.L88L; 1:56536988-56536988	skin	malignant_melanoma	Substitution - coding silent
c.285T>A; p.I95I; 1:56536967-56536967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.723G>A; p.T241T; 1:56512063-56512063	skin	malignant_melanoma	Substitution - coding silent
c.262C>T; p.L88F; 1:56536990-56536990	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>A; p.T241T; 1:56512063-56512063	skin	malignant_melanoma	Substitution - coding silent
c.367G>A; p.V123M; 1:56524485-56524485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.153C>T; p.F51F; 1:56537099-56537099	skin	malignant_melanoma	Substitution - coding silent
c.498C>T; p.F166F; 1:56524354-56524354	skin	malignant_melanoma	Substitution - coding silent
c.763G>T; p.D255Y; 1:56512023-56512023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.863C>T; p.A288V; 1:56496624-56496624	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation