lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	85458
Symbol	DIXDC1
Synonymous	CCD1
Full name	DIX domain containing 1
Gene description	coiled-coil protein DIX1\|dixin
Cytoband	11q23.1
Gene type	protein-coding
Synonymous	MIM:610493; HGNC:HGNC:23695; Ensembl:ENSG00000150764; HPRD:16804; Vega:OTTHUMG00000166912

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.984T>C; p.G328G; 11:111985300-111985300	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.984T>C; p.G328G; 11:111985300-111985300	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1059+2T>C; p.?; 11:111986926-111986926	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.683G>A; p.S228N; 11:111980763-111980763	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1664C>T; p.T555M; 11:111995542-111995542	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596G>A; p.R199Q; 11:111974923-111974923	skin	malignant_melanoma	Substitution - Missense
c.1091G>A; p.R364K; 11:111989036-111989036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752G>A; p.G251E; 11:111980832-111980832	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.140G>A; p.R47Q; 11:111964628-111964628	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1002A>C; p.Q334H; 11:111985318-111985318	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1456A>T; p.N486Y; 11:111995040-111995040	central_nervous_system; brain	glioma	Substitution - Missense
c.1101G>T; p.Q367H; 11:111989046-111989046	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930T>C; p.N310N; 11:111985246-111985246	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.862G>A; p.E288K; 11:111982434-111982434	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1660G>T; p.E554*; 11:111995538-111995538	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.151C>T; p.R51W; 11:111964639-111964639	central_nervous_system; brain	glioma	Substitution - Missense
c.151C>T; p.R51W; 11:111964639-111964639	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1019G>T; p.S340I; 11:111986884-111986884	breast	carcinoma	Substitution - Missense
c.1969A>T; p.I657F; 11:112018956-112018956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.180C>T; p.I60I; 11:111964668-111964668	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1470T>C; p.N490N; 11:111995054-111995054	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2029G>A; p.E677K; 11:112019016-112019016	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1824G>A; p.R608R; 11:112016761-112016761	skin	malignant_melanoma	Substitution - coding silent
c.1665G>A; p.T555T; 11:111995543-111995543	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.515G>A; p.R172Q; 11:111974221-111974221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1588G>C; p.D530H; 11:111995466-111995466	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1344T>C; p.S448S; 11:111993570-111993570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.983G>A; p.G328D; 11:111985299-111985299	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1359C>A; p.H453Q; 11:111993585-111993585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1361A>C; p.Q454P; 11:111993587-111993587	breast	carcinoma	Substitution - Missense
c.1730G>T; p.R577L; 11:111996123-111996123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1957G>A; p.V653I; 11:112017874-112017874	liver	carcinoma	Substitution - Missense
c.1957G>A; p.V653I; 11:112017874-112017874	liver	carcinoma	Substitution - Missense
c.963C>T; p.P321P; 11:111985279-111985279	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1427C>T; p.A476V; 11:111993733-111993733	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1985A>G; p.D662G; 11:112018972-112018972	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>A; p.V177V; 11:111974237-111974237	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.496G>A; p.V166M; 11:111974202-111974202	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.496G>A; p.V166M; 11:111974202-111974202	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1872G>A; p.V624V; 11:112017789-112017789	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.466G>T; p.A156S; 11:111974172-111974172	urinary_tract; bladder	carcinoma	Substitution - Missense
c.111G>A; p.R37R; 11:111964599-111964599	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1756T>G; p.L586V; 11:112016693-112016693	liver	carcinoma	Substitution - Missense
c.1588G>A; p.D530N; 11:111995466-111995466	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1588G>A; p.D530N; 11:111995466-111995466	skin	malignant_melanoma	Substitution - Missense
c.1483C>T; p.P495S; 11:111995067-111995067	skin	malignant_melanoma	Substitution - Missense
c.492C>T; p.A164A; 11:111974198-111974198	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.575A>G; p.E192G; 11:111974902-111974902	skin	malignant_melanoma	Substitution - Missense
c.518C>A; p.S173*; 11:111974224-111974224	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1902T>C; p.D634D; 11:112017819-112017819	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1376G>T; p.R459L; 11:111993682-111993682	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1746T>C; p.P582P; 11:111996139-111996139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1401C>T; p.L467L; 11:111993707-111993707	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1488G>A; p.T496T; 11:111995072-111995072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1488G>A; p.T496T; 11:111995072-111995072	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1985_1986insTGG; p.D662_A663insG; 11:112018972-112018973	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - In frame
c.931G>A; p.G311R; 11:111985247-111985247	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.200A>G; p.K67R; 11:111968522-111968522	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.329G>A; p.G110E; 11:111974035-111974035	skin	malignant_melanoma	Substitution - Missense
c.1691G>A; p.R564Q; 11:111996084-111996084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254C>T; p.L418L; 11:111992989-111992989	skin	malignant_melanoma	Substitution - coding silent
c.982G>T; p.G328C; 11:111985298-111985298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1926C>A; p.H642Q; 11:112017843-112017843	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.870A>G; p.L290L; 11:111982442-111982442	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1882G>A; p.D628N; 11:112017799-112017799	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.415G>A; p.D139N; 11:111974121-111974121	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.864A>T; p.E288D; 11:111982436-111982436	ovary	other; neoplasm	Substitution - Missense
c.597G>T; p.R199R; 11:111974924-111974924	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1682G>T; p.R561I; 11:111995560-111995560	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.599C>T; p.A200V; 11:111974926-111974926	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1626C>T; p.G542G; 11:111995504-111995504	oesophagus	carcinoma	Substitution - coding silent
c.1919G>A; p.R640Q; 11:112017836-112017836	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1700C>T; p.S567L; 11:111996093-111996093	breast	carcinoma	Substitution - Missense
c.1656T>C; p.V552V; 11:111995534-111995534	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.877G>T; p.E293*; 11:111982449-111982449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.877G>T; p.E293*; 11:111982449-111982449	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1646G>A; p.R549H; 11:111995524-111995524	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1531G>A; p.D511N; 11:111995409-111995409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1730G>A; p.R577Q; 11:111996123-111996123	pancreas	carcinoma	Substitution - Missense
c.340T>C; p.S114P; 11:111974046-111974046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.816A>G; p.G272G; 11:111982388-111982388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1956delT; p.V653fs*20; 11:112017873-112017873	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2007G>A; p.G669G; 11:112018994-112018994	skin	malignant_melanoma	Substitution - coding silent
c.2043G>T; p.E681D; 11:112019030-112019030	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1645C>T; p.R549C; 11:111995523-111995523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.813T>C; p.P271P; 11:111982385-111982385	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.813T>C; p.P271P; 11:111982385-111982385	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1601A>C; p.H534P; 11:111995479-111995479	ovary	other; neoplasm	Substitution - Missense
c.810+1A>G; p.?; 11:111982380-111982380	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.810+1A>G; p.?; 11:111982380-111982380	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1051G>A; p.D351N; 11:111986916-111986916	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1396G>T; p.V466F; 11:111993702-111993702	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation