lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8503
Symbol	PIK3R3
Synonymous	p55\|p55-GAMMA\|p55PIK
Full name	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Gene description	PI3-kinase regulatory subunit gamma\|PI3-kinase subunit p55-gamma\|PI3K regulatory subunit gamma\|phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma\|phosphatidylinositol 3-kinase regulatory subunit gamma\|phosphatidylinositol 3-kinase, regulatory s
Cytoband	1p34.1
Gene type	protein-coding
Synonymous	MIM:606076; HGNC:HGNC:8981; Ensembl:ENSG00000117461; HPRD:05831; Vega:OTTHUMG00000008096

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.827G>A; p.R276H; 1:46055909-46055909	prostate	carcinoma	Substitution - Missense
c.818G>C; p.S273T; 1:46055918-46055918	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1083G>A; p.E361E; 1:46046022-46046022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.457G>T; p.D153Y; 1:46066949-46066949	thyroid	other; neoplasm	Substitution - Missense
c.601G>A; p.E201K; 1:46066074-46066074	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.930T>A; p.D310E; 1:46055806-46055806	stomach	adenocarcinoma	Substitution - Missense
c.282delA; p.M96fs*7; 1:46077547-46077547	large_intestine; colon	carcinoma	Deletion - Frameshift
c.917G>A; p.R306Q; 1:46055819-46055819	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.286delA; p.M96fs*7; 1:46077543-46077543	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.925C>T; p.R309*; 1:46055811-46055811	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1094G>T; p.R365L; 1:46046011-46046011	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.884T>C; p.M295T; 1:46055852-46055852	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.884T>C; p.M295T; 1:46055852-46055852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1336G>A; p.V446I; 1:46043723-46043723	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1222A>C; p.S408R; 1:46043837-46043837	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.194G>T; p.W65L; 1:46080663-46080663	large_intestine; colon	adenoma	Substitution - Missense
c.849T>A; p.N283K; 1:46055887-46055887	skin	malignant_melanoma	Substitution - Missense
c.1275G>A; p.L425L; 1:46043784-46043784	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.434T>C; p.L145P; 1:46066972-46066972	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.883delA; p.M295fs*1; 1:46055853-46055853	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.883delA; p.M295fs*1; 1:46055853-46055853	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.883delA; p.M295fs*1; 1:46055853-46055853	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.883delA; p.M295fs*1; 1:46055853-46055853	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.511G>T; p.E171*; 1:46066164-46066164	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1373C>T; p.S458L; 1:46043686-46043686	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.962T>C; p.V321A; 1:46046605-46046605	pancreas	carcinoma	Substitution - Missense
c.962T>C; p.V321A; 1:46046605-46046605	pancreas	carcinoma	Substitution - Missense
c.682G>A; p.E228K; 1:46062011-46062011	skin	malignant_melanoma	Substitution - Missense
c.962T>C; p.V321A; 1:46046605-46046605	pancreas	carcinoma	Substitution - Missense
c.1103C>T; p.A368V; 1:46046002-46046002	breast	carcinoma	Substitution - Missense
c.148C>T; p.P50S; 1:46080709-46080709	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73G>T; p.E25*; 1:46131880-46131880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.883_884insA; p.M295fs*3; 1:46055852-46055853	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.891C>T; p.S297S; 1:46055845-46055845	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.268C>T; p.R90*; 1:46077561-46077561	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.765-1G>T; p.?; 1:46055972-46055972	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.958G>A; p.G320R; 1:46046609-46046609	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.891C>A; p.S297R; 1:46055845-46055845	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1334A>G; p.N445S; 1:46043725-46043725	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1236C>A; p.G412G; 1:46043823-46043823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1218C>A; p.I406I; 1:46043841-46043841	breast	carcinoma	Substitution - coding silent
c.965G>A; p.R322K; 1:46046602-46046602	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>T; p.E239*; 1:46061978-46061978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.715G>T; p.E239*; 1:46061978-46061978	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1241G>A; p.G414D; 1:46043818-46043818	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1147C>T; p.R383C; 1:46045958-46045958	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1147C>T; p.R383C; 1:46045958-46045958	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1147C>T; p.R383C; 1:46045958-46045958	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.677T>A; p.F226Y; 1:46062016-46062016	liver	carcinoma	Substitution - Missense
c.677T>A; p.F226Y; 1:46062016-46062016	liver	carcinoma	Substitution - Missense
c.576T>C; p.S192S; 1:46066099-46066099	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.852A>C; p.Q284H; 1:46055884-46055884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.376G>C; p.D126H; 1:46067030-46067030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1297C>A; p.Q433K; 1:46043762-46043762	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.57G>A; p.M19I; 1:46131896-46131896	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.878A>C; p.K293T; 1:46055858-46055858	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1187T>C; p.V396A; 1:46045918-46045918	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.878A>C; p.K293T; 1:46055858-46055858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878A>C; p.K293T; 1:46055858-46055858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.551A>T; p.Y184F; 1:46066124-46066124	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.380C>T; p.P127L; 1:46067026-46067026	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1020C>T; p.N340N; 1:46046085-46046085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1291C>T; p.H431Y; 1:46043768-46043768	skin	malignant_melanoma	Substitution - Missense
c.977T>G; p.L326R; 1:46046590-46046590	breast	carcinoma	Substitution - Missense
c.977T>G; p.L326R; 1:46046590-46046590	breast	carcinoma	Substitution - Missense
c.145G>T; p.V49F; 1:46080712-46080712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.600delA; p.E201fs*11; 1:46066075-46066075	prostate	carcinoma	Deletion - Frameshift
c.69G>A; p.S23S; 1:46131884-46131884	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1321_1323delAAC; p.N441delN; 1:46043736-46043738	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1138T>C; p.F380L; 1:46045967-46045967	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.733C>T; p.R245C; 1:46061960-46061960	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.794C>T; p.S265L; 1:46055942-46055942	skin	malignant_melanoma	Substitution - Missense
c.1374G>A; p.S458S; 1:46043685-46043685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.916C>G; p.R306G; 1:46055820-46055820	liver	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation