lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8491
Symbol	MAP4K3
Synonymous	GLK\|MAPKKKK3\|MEKKK 3\|MEKKK3\|RAB8IPL1
Full name	mitogen-activated protein kinase kinase kinase kinase 3
Gene description	MAPK/ERK kinase kinase kinase 3\|MEK kinase kinase 3\|germinal center kinase-like kinase\|germinal center kinase-related protein kinase
Cytoband	2p22.1
Gene type	protein-coding
Synonymous	MIM:604921; HGNC:HGNC:6865; Ensembl:ENSG00000011566; HPRD:05373; Vega:OTTHUMG00000102127

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1621A>G; p.K541E; 2:39282521-39282521	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1359T>G; p.D453E; 2:39288236-39288236	skin	malignant_melanoma	Substitution - Missense
c.2276C>A; p.P759Q; 2:39260638-39260638	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>T; p.P731S; 2:39260723-39260723	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1354G>A; p.E452K; 2:39288241-39288241	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.781_782insA; p.R261fs*5; 2:39325755-39325756	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.781_782insA; p.R261fs*5; 2:39325755-39325756	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1855+9A>C; p.?; 2:39272473-39272473	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.586G>A; p.D196N; 2:39326222-39326222	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.162C>A; p.D54E; 2:39356332-39356332	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.400C>T; p.H134Y; 2:39336934-39336934	skin; trunk	malignant_melanoma	Substitution - Missense
c.1804C>T; p.R602*; 2:39272533-39272533	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1804C>T; p.R602*; 2:39272533-39272533	breast	carcinoma	Substitution - Nonsense
c.627G>T; p.E209D; 2:39326181-39326181	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.627G>T; p.E209D; 2:39326181-39326181	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.34C>A; p.P12T; 2:39436954-39436954	prostate	carcinoma	Substitution - Missense
c.983G>T; p.R328L; 2:39315324-39315324	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.94A>G; p.K32E; 2:39436894-39436894	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1230A>G; p.A410A; 2:39292814-39292814	breast	carcinoma	Substitution - coding silent
c.1271+4A>G; p.?; 2:39292769-39292769	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.2385A>G; p.I795M; 2:39258433-39258433	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.80A>G; p.Y27C; 2:39436908-39436908	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2143G>T; p.D715Y; 2:39260771-39260771	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1469C>T; p.A490V; 2:39288126-39288126	skin	malignant_melanoma	Substitution - Missense
c.1805G>T; p.R602L; 2:39272532-39272532	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.683A>C; p.K228T; 2:39325941-39325941	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2111C>A; p.P704Q; 2:39265228-39265228	skin	malignant_melanoma	Substitution - Missense
c.2282C>T; p.S761F; 2:39260632-39260632	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1715-1G>A; p.?; 2:39278487-39278487	urinary_tract; bladder	carcinoma	Unknown
c.226T>C; p.Y76H; 2:39356268-39356268	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2558C>T; p.S853L; 2:39251869-39251869	skin	malignant_melanoma	Substitution - Missense
c.2558C>T; p.S853L; 2:39251869-39251869	skin	malignant_melanoma	Substitution - Missense
c.2615G>A; p.S872N; 2:39250688-39250688	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>A; p.G123R; 2:39336967-39336967	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.616G>C; p.E206Q; 2:39326192-39326192	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.435G>A; p.T145T; 2:39333554-39333554	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1418A>G; p.Q473R; 2:39288177-39288177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2363T>A; p.L788H; 2:39258533-39258533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1218A>G; p.R406R; 2:39292826-39292826	ovary	other; neoplasm	Substitution - coding silent
c.784C>A; p.P262T; 2:39325753-39325753	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.927T>C; p.V309V; 2:39315380-39315380	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1241A>G; p.D414G; 2:39292803-39292803	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2155C>T; p.P719S; 2:39260759-39260759	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1230A>T; p.A410A; 2:39292814-39292814	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.964G>A; p.V322M; 2:39315343-39315343	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237G>T; p.E413*; 2:39292807-39292807	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1763T>C; p.L588P; 2:39278438-39278438	skin	malignant_melanoma	Substitution - Missense
c.1795-7delT; p.?; 2:39272549-39272549	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.2103G>T; p.W701C; 2:39265236-39265236	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2379T>C; p.C793C; 2:39258439-39258439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2379T>C; p.C793C; 2:39258439-39258439	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1294C>T; p.P432S; 2:39290312-39290312	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.545T>C; p.V182A; 2:39326263-39326263	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.545T>C; p.V182A; 2:39326263-39326263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2090T>G; p.V697G; 2:39265249-39265249	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.246G>A; p.R82R; 2:39343452-39343452	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1730T>G; p.F577C; 2:39278471-39278471	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.950C>T; p.S317L; 2:39315357-39315357	skin	malignant_melanoma	Substitution - Missense
c.1000G>T; p.G334C; 2:39309517-39309517	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1717C>T; p.Q573*; 2:39278484-39278484	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2490G>A; p.V830V; 2:39254501-39254501	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.23C>T; p.S8F; 2:39436965-39436965	skin	malignant_melanoma	Substitution - Missense
c.835C>T; p.R279W; 2:39325601-39325601	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.314C>G; p.T105S; 2:39337578-39337578	liver	carcinoma	Substitution - Missense
c.1695G>C; p.W565C; 2:39280291-39280291	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.314C>G; p.T105S; 2:39337578-39337578	liver	carcinoma	Substitution - Missense
c.626A>G; p.E209G; 2:39326182-39326182	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.626A>G; p.E209G; 2:39326182-39326182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.626A>G; p.E209G; 2:39326182-39326182	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2503A>T; p.K835*; 2:39254488-39254488	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1243G>T; p.D415Y; 2:39292801-39292801	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1984G>T; p.V662L; 2:39267237-39267237	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2522G>A; p.R841K; 2:39254469-39254469	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2419A>T; p.S807C; 2:39258399-39258399	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2258G>A; p.R753Q; 2:39260656-39260656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2258G>A; p.R753Q; 2:39260656-39260656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2519G>A; p.G840D; 2:39254472-39254472	liver	carcinoma	Substitution - Missense
c.2378G>A; p.C793Y; 2:39258440-39258440	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2519G>A; p.G840D; 2:39254472-39254472	liver	carcinoma	Substitution - Missense
c.2519G>A; p.G840D; 2:39254472-39254472	liver	carcinoma	Substitution - Missense
c.588T>C; p.D196D; 2:39326220-39326220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233T>G; p.H411Q; 2:39292811-39292811	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1603G>A; p.G535S; 2:39282539-39282539	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.877G>T; p.D293Y; 2:39325559-39325559	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2650T>C; p.L884L; 2:39250653-39250653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2427A>C; p.K809N; 2:39258391-39258391	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2257C>T; p.R753*; 2:39260657-39260657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2257C>T; p.R753*; 2:39260657-39260657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.379C>T; p.L127F; 2:39336955-39336955	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1737C>T; p.A579A; 2:39278464-39278464	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2309-1G>A; p.?; 2:39258588-39258588	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1939C>T; p.P647S; 2:39272317-39272317	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.185T>G; p.I62S; 2:39356309-39356309	skin	malignant_melanoma	Substitution - Missense
c.2201A>G; p.E734G; 2:39260713-39260713	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1570G>C; p.E524Q; 2:39286869-39286869	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>A; p.V104I; 2:39343388-39343388	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1247A>G; p.E416G; 2:39292797-39292797	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950C>G; p.S317*; 2:39315357-39315357	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1102A>C; p.T368P; 2:39307960-39307960	skin	malignant_melanoma	Substitution - Missense
c.1051G>A; p.E351K; 2:39309466-39309466	pancreas	NS	Substitution - Missense
c.1886T>G; p.L629*; 2:39272370-39272370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1598G>C; p.S533T; 2:39282544-39282544	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>A; p.D54N; 2:39356334-39356334	NS	NS	Substitution - Missense
c.1417C>A; p.Q473K; 2:39288178-39288178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.544G>T; p.V182F; 2:39326264-39326264	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.832A>G; p.T278A; 2:39325604-39325604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2174T>C; p.F725S; 2:39260740-39260740	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2142A>G; p.I714M; 2:39260772-39260772	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1878C>T; p.S626S; 2:39272378-39272378	skin	malignant_melanoma	Substitution - coding silent
c.249A>T; p.R83R; 2:39343449-39343449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1639T>G; p.C547G; 2:39280347-39280347	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1639T>G; p.C547G; 2:39280347-39280347	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.866T>G; p.V289G; 2:39325570-39325570	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1888C>T; p.P630S; 2:39272368-39272368	skin	malignant_melanoma	Substitution - Missense
c.2349G>A; p.E783E; 2:39258547-39258547	skin	malignant_melanoma	Substitution - coding silent
c.1369G>T; p.G457*; 2:39288226-39288226	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.536C>T; p.A179V; 2:39326272-39326272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.588T>A; p.D196E; 2:39326220-39326220	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.509C>T; p.S170F; 2:39331938-39331938	skin	malignant_melanoma	Substitution - Missense
c.849C>T; p.I283I; 2:39325587-39325587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.919-2A>G; p.?; 2:39315390-39315390	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.72C>T; p.S24S; 2:39436916-39436916	liver	carcinoma	Substitution - coding silent
c.85G>A; p.D29N; 2:39436903-39436903	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.72C>T; p.S24S; 2:39436916-39436916	liver	carcinoma	Substitution - coding silent
c.2005A>T; p.T669S; 2:39267216-39267216	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2005A>T; p.T669S; 2:39267216-39267216	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1997T>A; p.I666N; 2:39267224-39267224	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1997T>A; p.I666N; 2:39267224-39267224	large_intestine; colon	carcinoma	Substitution - Missense
c.1668C>T; p.P556P; 2:39280318-39280318	skin	malignant_melanoma	Substitution - coding silent
c.2067T>A; p.C689*; 2:39265272-39265272	stomach	adenocarcinoma	Substitution - Nonsense
c.1219G>A; p.G407R; 2:39292825-39292825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.900C>T; p.F300F; 2:39325536-39325536	breast	carcinoma	Substitution - coding silent
c.900C>T; p.F300F; 2:39325536-39325536	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1610C>T; p.P537L; 2:39282532-39282532	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1855+9A>T; p.?; 2:39272473-39272473	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1954C>T; p.P652S; 2:39272302-39272302	skin	malignant_melanoma	Substitution - Missense
c.869A>T; p.N290I; 2:39325567-39325567	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2184G>T; p.L728L; 2:39260730-39260730	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1419A>C; p.Q473H; 2:39288176-39288176	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1973G>A; p.R658K; 2:39272283-39272283	skin	malignant_melanoma	Substitution - Missense
c.1240G>C; p.D414H; 2:39292804-39292804	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2667T>C; p.G889G; 2:39250636-39250636	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2678G>T; p.S893I; 2:39250625-39250625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.T255I; 2:39325773-39325773	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1463C>A; p.P488H; 2:39288132-39288132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.35C>G; p.P12R; 2:39436953-39436953	skin	malignant_melanoma	Substitution - Missense
c.502C>T; p.R168W; 2:39331945-39331945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2578A>T; p.R860W; 2:39251849-39251849	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.90C>T; p.V30V; 2:39436898-39436898	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.432A>C; p.L144F; 2:39333557-39333557	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.602G>T; p.G201V; 2:39326206-39326206	breast	carcinoma	Substitution - Missense
c.401A>C; p.H134P; 2:39336933-39336933	skin	malignant_melanoma	Substitution - Missense
c.2486G>T; p.S829I; 2:39254505-39254505	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1606C>A; p.L536I; 2:39282536-39282536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.663-2A>T; p.?; 2:39325963-39325963	lung	carcinoma; small_cell_carcinoma	Unknown
c.1289A>C; p.K430T; 2:39290317-39290317	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2071G>A; p.A691T; 2:39265268-39265268	stomach	carcinoma	Substitution - Missense
c.872A>C; p.N291T; 2:39325564-39325564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2005A>G; p.T669A; 2:39267216-39267216	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2005A>G; p.T669A; 2:39267216-39267216	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.603A>C; p.G201G; 2:39326205-39326205	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1619C>A; p.P540H; 2:39282523-39282523	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2398C>A; p.L800I; 2:39258420-39258420	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1145G>A; p.G382E; 2:39299776-39299776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.181G>A; p.E61K; 2:39356313-39356313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1635T>G; p.G545G; 2:39280351-39280351	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.997+2T>A; p.?; 2:39315308-39315308	liver	carcinoma	Unknown
c.155-2_155delAGG; p.?; 2:39356339-39356341	breast	carcinoma	Unknown
c.444T>C; p.G148G; 2:39333545-39333545	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1746G>T; p.G582G; 2:39278455-39278455	skin	malignant_melanoma	Substitution - coding silent
c.132T>C; p.I44I; 2:39378088-39378088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2058A>C; p.K686N; 2:39265281-39265281	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation