lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	847
Symbol	CAT
Synonymous	-
Full name	catalase
Gene description	-
Cytoband	11p13
Gene type	protein-coding
Synonymous	MIM:115500; HGNC:HGNC:1516; Ensembl:ENSG00000121691; HPRD:00282; Vega:OTTHUMG00000044353

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.171C>T; p.F57F; 11:34449296-34449296	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.668T>G; p.V223G; 11:34453883-34453883	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415G>T; p.E139*; 11:34452142-34452142	bone; rib	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.452C>T; p.P151L; 11:34452179-34452179	skin	malignant_melanoma	Substitution - Missense
c.140G>A; p.R47H; 11:34449265-34449265	urinary_tract; bladder	carcinoma	Substitution - Missense
c.5C>A; p.A2D; 11:34439018-34439018	liver	carcinoma	Substitution - Missense
c.5C>A; p.A2D; 11:34439018-34439018	liver	carcinoma	Substitution - Missense
c.1331G>A; p.R444Q; 11:34468292-34468292	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.983A>G; p.E328G; 11:34456744-34456744	liver	carcinoma	Substitution - Missense
c.1321A>T; p.T441S; 11:34464230-34464230	skin	malignant_melanoma	Substitution - Missense
c.616C>T; p.P206S; 11:34453831-34453831	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.616C>T; p.P206S; 11:34453831-34453831	skin	malignant_melanoma	Substitution - Missense
c.720G>A; p.Q240Q; 11:34456019-34456019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1106A>G; p.N369S; 11:34461300-34461300	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1094G>T; p.R365L; 11:34461288-34461288	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.750G>A; p.A250A; 11:34456049-34456049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1395C>T; p.G465G; 11:34468356-34468356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.750G>A; p.A250A; 11:34456049-34456049	oesophagus	carcinoma	Substitution - coding silent
c.1057-2A>G; p.?; 11:34461249-34461249	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.863A>G; p.Q288R; 11:34456162-34456162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1056G>T; p.Q352H; 11:34456817-34456817	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1056G>T; p.Q352H; 11:34456817-34456817	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.159G>A; p.Q53Q; 11:34449284-34449284	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1047A>T; p.K349N; 11:34456808-34456808	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1093C>T; p.R365C; 11:34461287-34461287	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.536C>T; p.P179L; 11:34453145-34453145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1559C>T; p.A520V; 11:34471408-34471408	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1559C>T; p.A520V; 11:34471408-34471408	breast	carcinoma	Substitution - Missense
c.514C>T; p.P172S; 11:34453123-34453123	skin	malignant_melanoma	Substitution - Missense
c.886C>T; p.P296S; 11:34456185-34456185	skin	malignant_melanoma	Substitution - Missense
c.972T>C; p.N324N; 11:34456733-34456733	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.451C>T; p.P151S; 11:34452178-34452178	skin	malignant_melanoma	Substitution - Missense
c.733C>T; p.L245F; 11:34456032-34456032	skin	malignant_melanoma	Substitution - Missense
c.233G>C; p.G78A; 11:34449358-34449358	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.753G>A; p.A251A; 11:34456052-34456052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1072T>C; p.Y358H; 11:34461266-34461266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.E330K; 11:34456749-34456749	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1087C>A; p.R363S; 11:34461281-34461281	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>A; p.R363S; 11:34461281-34461281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1494C>A; p.D498E; 11:34471017-34471017	skin	malignant_melanoma	Substitution - Missense
c.1161G>T; p.Q387H; 11:34461355-34461355	pancreas	NS	Substitution - Missense
c.1030G>A; p.E344K; 11:34456791-34456791	skin	malignant_melanoma	Substitution - Missense
c.1167C>T; p.D389D; 11:34461361-34461361	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.189T>C; p.H63H; 11:34449314-34449314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1196-2A>G; p.?; 11:34464103-34464103	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1061G>A; p.R354H; 11:34461255-34461255	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.335G>A; p.R112Q; 11:34451084-34451084	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.327C>T; p.I109I; 11:34451076-34451076	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1479C>G; p.I493M; 11:34471002-34471002	urinary_tract; bladder	carcinoma	Substitution - Missense
c.239-5G>A; p.?; 11:34450983-34450983	stomach	carcinoma; adenocarcinoma	Unknown
c.1344G>C; p.V448V; 11:34468305-34468305	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.820T>C; p.Y274H; 11:34456119-34456119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.380G>A; p.R127Q; 11:34452107-34452107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1428G>C; p.K476N; 11:34468389-34468389	breast	carcinoma	Substitution - Missense
c.762C>T; p.S254S; 11:34456061-34456061	stomach	adenocarcinoma	Substitution - coding silent
c.849C>A; p.V283V; 11:34456148-34456148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.822C>T; p.Y274Y; 11:34456121-34456121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.891C>T; p.F297F; 11:34456190-34456190	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.116T>G; p.L39R; 11:34449241-34449241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1377G>A; p.L459L; 11:34468338-34468338	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1087C>T; p.R363C; 11:34461281-34461281	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.146C>T; p.P49L; 11:34449271-34449271	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.703C>T; p.H235Y; 11:34453918-34453918	skin	malignant_melanoma	Substitution - Missense
c.1388T>C; p.I463T; 11:34468349-34468349	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1003G>A; p.D335N; 11:34456764-34456764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1196-1G>T; p.?; 11:34464104-34464104	stomach	carcinoma; adenocarcinoma	Unknown
c.334C>T; p.R112W; 11:34451083-34451083	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.288G>A; p.K96K; 11:34451037-34451037	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.289G>A; p.A97T; 11:34451038-34451038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.260T>A; p.V87D; 11:34451009-34451009	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1547G>A; p.G516E; 11:34471396-34471396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.529A>G; p.K177E; 11:34453138-34453138	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1000T>G; p.F334V; 11:34456761-34456761	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.146C>A; p.P49H; 11:34449271-34449271	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1088G>A; p.R363H; 11:34461282-34461282	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.711_711+1delGG; p.?; 11:34453926-34453927	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1027A>G; p.I343V; 11:34456788-34456788	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.139C>G; p.R47G; 11:34449264-34449264	breast	carcinoma	Substitution - Missense
c.638A>G; p.N213S; 11:34453853-34453853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1434G>A; p.A478A; 11:34468395-34468395	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.749C>T; p.A250V; 11:34456048-34456048	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>T; p.V87V; 11:34451010-34451010	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.173C>G; p.T58S; 11:34449298-34449298	parathyroid	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation