lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8454
Symbol	CUL1
Synonymous	-
Full name	cullin 1
Gene description	CUL-1\|cullin-1
Cytoband	7q36.1
Gene type	protein-coding
Synonymous	MIM:603134; HGNC:HGNC:2551; Ensembl:ENSG00000055130; HPRD:04389; Vega:OTTHUMG00000152776

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.721G>C; p.E241Q; 7:148760428-148760428	breast	carcinoma	Substitution - Missense
c.1369G>C; p.E457Q; 7:148787010-148787010	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1574T>C; p.L525S; 7:148788651-148788651	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>T; p.E241D; 7:148760430-148760430	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1313A>T; p.E438V; 7:148786565-148786565	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.436C>T; p.R146C; 7:148757103-148757103	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.436C>T; p.R146C; 7:148757103-148757103	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.916G>C; p.E306Q; 7:148766687-148766687	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.436C>T; p.R146C; 7:148757103-148757103	breast	carcinoma	Substitution - Missense
c.660A>G; p.A220A; 7:148760367-148760367	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.482C>T; p.S161L; 7:148757149-148757149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.676A>T; p.T226S; 7:148760383-148760383	skin; arm	malignant_melanoma	Substitution - Missense
c.1914A>C; p.Q638H; 7:148797826-148797826	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.624C>T; p.Y208Y; 7:148759637-148759637	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1937C>T; p.S646L; 7:148797849-148797849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1067G>A; p.G356E; 7:148767733-148767733	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1937C>T; p.S646L; 7:148797849-148797849	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1937C>T; p.S646L; 7:148797849-148797849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437G>A; p.R146H; 7:148757104-148757104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1460G>A; p.S487N; 7:148787101-148787101	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.484-2A>G; p.?; 7:148759302-148759302	stomach	carcinoma; adenocarcinoma	Unknown
c.95A>G; p.Y32C; 7:148730217-148730217	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1839G>A; p.Q613Q; 7:148792758-148792758	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1518C>T; p.R506R; 7:148788595-148788595	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.625G>A; p.V209M; 7:148759638-148759638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2309A>G; p.D770G; 7:148800560-148800560	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.866G>A; p.R289K; 7:148766637-148766637	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1627G>A; p.G543R; 7:148789779-148789779	skin	malignant_melanoma	Substitution - Missense
c.1271G>C; p.R424P; 7:148784050-148784050	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1271G>C; p.R424P; 7:148784050-148784050	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2039T>C; p.L680S; 7:148798580-148798580	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.60C>T; p.I20I; 7:148730182-148730182	skin	malignant_melanoma	Substitution - coding silent
c.1593A>G; p.L531L; 7:148788670-148788670	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1675-7T>C; p.?; 7:148790303-148790303	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1397A>C; p.Y466S; 7:148787038-148787038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2138C>T; p.A713V; 7:148799276-148799276	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1418G>T; p.R473M; 7:148787059-148787059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534+2T>C; p.?; 7:148759356-148759356	stomach	carcinoma; adenocarcinoma	Unknown
c.2138C>T; p.A713V; 7:148799276-148799276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1382T>G; p.V461G; 7:148787023-148787023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1991A>G; p.K664R; 7:148797980-148797980	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.197G>T; p.G66V; 7:148754032-148754032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.112G>A; p.A38T; 7:148730234-148730234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2197G>A; p.E733K; 7:148799335-148799335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2290C>T; p.R764*; 7:148800541-148800541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2290C>T; p.R764*; 7:148800541-148800541	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2235A>T; p.R745R; 7:148799373-148799373	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2112G>T; p.E704D; 7:148798653-148798653	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.658G>A; p.A220T; 7:148760365-148760365	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.503G>C; p.R168T; 7:148759323-148759323	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1066G>T; p.G356*; 7:148767732-148767732	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.380G>A; p.R127Q; 7:148757047-148757047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.658G>A; p.A220T; 7:148760365-148760365	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.503G>C; p.R168T; 7:148759323-148759323	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1428C>G; p.H476Q; 7:148787069-148787069	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1343A>G; p.Q448R; 7:148786595-148786595	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2196C>T; p.G732G; 7:148799334-148799334	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2185C>T; p.Q729*; 7:148799323-148799323	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2274G>T; p.E758D; 7:148800525-148800525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2196C>T; p.G732G; 7:148799334-148799334	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1453G>A; p.E485K; 7:148787094-148787094	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2094C>G; p.T698T; 7:148798635-148798635	breast	carcinoma	Substitution - coding silent
c.1453G>A; p.E485K; 7:148787094-148787094	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1453G>A; p.E485K; 7:148787094-148787094	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.855T>C; p.D285D; 7:148766626-148766626	breast	carcinoma	Substitution - coding silent
c.1453G>A; p.E485K; 7:148787094-148787094	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1453G>A; p.E485K; 7:148787094-148787094	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1123delA; p.K376fs*6; 7:148783822-148783822	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.469T>G; p.Y157D; 7:148757136-148757136	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.122G>A; p.R41K; 7:148730244-148730244	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1730G>A; p.R577Q; 7:148790365-148790365	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1536C>T; p.G512G; 7:148788613-148788613	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.368_369GG>TT; p.W123F; 7:148757035-148757036	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1667C>T; p.P556L; 7:148789819-148789819	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2017C>A; p.L673I; 7:148798006-148798006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2266C>G; p.L756V; 7:148800517-148800517	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1840T>C; p.Y614H; 7:148792759-148792759	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1903_1904insT; p.L636fs*19; 7:148797815-148797816	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1739C>T; p.T580M; 7:148790374-148790374	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2278G>C; p.E760Q; 7:148800529-148800529	liver	carcinoma	Substitution - Missense
c.1191+8C>T; p.?; 7:148783898-148783898	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.748G>T; p.E250*; 7:148760455-148760455	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1259A>T; p.E420V; 7:148784038-148784038	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1259A>T; p.E420V; 7:148784038-148784038	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1948-6T>A; p.?; 7:148797931-148797931	prostate	carcinoma	Unknown
c.2146G>A; p.V716M; 7:148799284-148799284	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2136G>A; p.Q712Q; 7:148798677-148798677	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.422A>G; p.N141S; 7:148757089-148757089	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1529A>G; p.D510G; 7:148788606-148788606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.451G>A; p.E151K; 7:148757118-148757118	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1216A>C; p.N406H; 7:148783995-148783995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.757C>T; p.Q253*; 7:148760464-148760464	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2109C>T; p.I703I; 7:148798650-148798650	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1711G>C; p.A571P; 7:148790346-148790346	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.457C>T; p.R153*; 7:148757124-148757124	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1517G>A; p.R506H; 7:148788594-148788594	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.341G>C; p.S114T; 7:148757008-148757008	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1517G>A; p.R506H; 7:148788594-148788594	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.962G>A; p.R321H; 7:148767628-148767628	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.439C>T; p.R147C; 7:148757106-148757106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2163G>A; p.M721I; 7:148799301-148799301	skin	malignant_melanoma	Substitution - Missense
c.796G>C; p.A266P; 7:148766567-148766567	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.37A>C; p.K13Q; 7:148730159-148730159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2120G>A; p.R707H; 7:148798661-148798661	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1678G>A; p.E560K; 7:148790313-148790313	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1122_1123insA; p.Y377fs*12; 7:148783821-148783822	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2140G>A; p.A714T; 7:148799278-148799278	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1122_1123insA; p.Y377fs*12; 7:148783821-148783822	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1122_1123insA; p.Y377fs*12; 7:148783821-148783822	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.507_510delCTGT; p.L171fs*4; 7:148759327-148759330	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.1258G>A; p.E420K; 7:148784037-148784037	urinary_tract; bladder	carcinoma	Substitution - Missense
c.610G>A; p.V204I; 7:148759623-148759623	skin	malignant_melanoma	Substitution - Missense
c.2106C>T; p.N702N; 7:148798647-148798647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.753C>A; p.F251L; 7:148760460-148760460	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1643A>C; p.Q548P; 7:148789795-148789795	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1447G>A; p.D483N; 7:148787088-148787088	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.1447G>A; p.D483N; 7:148787088-148787088	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1447G>A; p.D483N; 7:148787088-148787088	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.25C>T; p.P9S; 7:148730147-148730147	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1327G>C; p.E443Q; 7:148786579-148786579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.683A>G; p.Y228C; 7:148760390-148760390	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.105G>T; p.Q35H; 7:148730227-148730227	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2275A>G; p.K759E; 7:148800526-148800526	prostate	carcinoma	Substitution - Missense
c.1856C>T; p.A619V; 7:148792775-148792775	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1018T>G; p.L340V; 7:148767684-148767684	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1911G>A; p.A637A; 7:148797823-148797823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1699A>G; p.T567A; 7:148790334-148790334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1467C>T; p.I489I; 7:148787108-148787108	skin	malignant_melanoma	Substitution - coding silent
c.1446C>T; p.D482D; 7:148787087-148787087	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.271C>T; p.R91*; 7:148754106-148754106	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.271C>T; p.R91*; 7:148754106-148754106	breast	carcinoma	Substitution - Nonsense
c.733A>G; p.T245A; 7:148760440-148760440	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.5C>G; p.S2W; 7:148730127-148730127	pancreas	carcinoma	Substitution - Missense
c.1938G>A; p.S646S; 7:148797850-148797850	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.874G>A; p.E292K; 7:148766645-148766645	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1661C>T; p.A554V; 7:148789813-148789813	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256C>T; p.P419L; 7:148784035-148784035	skin	malignant_melanoma	Substitution - Missense
c.1809G>A; p.A603A; 7:148792728-148792728	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1809G>A; p.A603A; 7:148792728-148792728	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.856G>A; p.E286K; 7:148766627-148766627	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.856G>A; p.E286K; 7:148766627-148766627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.856G>A; p.E286K; 7:148766627-148766627	urinary_tract; bladder	carcinoma	Substitution - Missense
c.74G>T; p.R25I; 7:148730196-148730196	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.372A>C; p.E124D; 7:148757039-148757039	liver	carcinoma	Substitution - Missense
c.1490G>A; p.G497E; 7:148788567-148788567	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.372A>C; p.E124D; 7:148757039-148757039	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.961C>T; p.R321C; 7:148767627-148767627	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>T; p.R321C; 7:148767627-148767627	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1847C>T; p.T616M; 7:148792766-148792766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1671A>G; p.S557S; 7:148789823-148789823	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.12C>G; p.T4T; 7:148730134-148730134	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2000C>T; p.T667I; 7:148797989-148797989	skin	malignant_melanoma	Substitution - Missense
c.1782C>A; p.C594*; 7:148790417-148790417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1391A>C; p.K464T; 7:148787032-148787032	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>T; p.H280Y; 7:148766609-148766609	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2272G>C; p.E758Q; 7:148800523-148800523	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.187C>T; p.R63*; 7:148754022-148754022	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2272G>C; p.E758Q; 7:148800523-148800523	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.158G>A; p.C53Y; 7:148753993-148753993	central_nervous_system; brain	glioma	Substitution - Missense
c.2076G>A; p.Q692Q; 7:148798617-148798617	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1547A>G; p.D516G; 7:148788624-148788624	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation