lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	843
Symbol	CASP10
Synonymous	ALPS2\|FLICE2\|MCH4
Full name	caspase 10, apoptosis-related cysteine peptidase
Gene description	CASP-10\|FADD-like ICE2\|FAS-associated death domain protein interleukin-1B-converting enzyme 2\|ICE-like apoptotic protease 4\|apoptotic protease MCH-4\|caspase 10, apoptosis-related cysteine protease\|caspase-10\|interleukin-1B-converting enzyme 2
Cytoband	2q33-q34
Gene type	protein-coding
Synonymous	MIM:601762; HGNC:HGNC:1500; Ensembl:ENSG00000003400; HPRD:03458; Vega:OTTHUMG00000132818

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.293C>G; p.T98S; 2:201186070-201186070	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.599C>T; p.P200L; 2:201195863-201195863	skin	malignant_melanoma	Substitution - Missense
c.1118C>T; p.P373L; 2:201209265-201209265	skin	malignant_melanoma	Substitution - Missense
c.325C>T; p.R109*; 2:201186102-201186102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.325C>T; p.R109*; 2:201186102-201186102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.195C>A; p.L65L; 2:201185972-201185972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.342G>A; p.L114L; 2:201186119-201186119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1349G>A; p.R450Q; 2:201209496-201209496	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1563A>T; p.S521S; 2:201217735-201217735	liver	carcinoma	Substitution - coding silent
c.1563A>T; p.S521S; 2:201217735-201217735	liver	carcinoma	Substitution - coding silent
c.1360G>C; p.E454Q; 2:201209507-201209507	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1123C>T; p.R375W; 2:201209270-201209270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225C>T; p.D75D; 2:201186002-201186002	skin	malignant_melanoma	Substitution - coding silent
c.756C>T; p.V252V; 2:201205916-201205916	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.616G>A; p.E206K; 2:201195880-201195880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648C>T; p.S216S; 2:201195912-201195912	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.251A>G; p.Y84C; 2:201186028-201186028	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.42A>C; p.K14N; 2:201185819-201185819	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.42A>C; p.K14N; 2:201185819-201185819	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.555A>G; p.I185M; 2:201193097-201193097	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1096T>A; p.S366T; 2:201209243-201209243	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1096T>A; p.S366T; 2:201209243-201209243	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.852C>T; p.G284G; 2:201208113-201208113	skin	malignant_melanoma	Substitution - coding silent
c.1005C>T; p.V335V; 2:201209152-201209152	skin	malignant_melanoma	Substitution - coding silent
c.669C>T; p.F223F; 2:201195933-201195933	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.247C>A; p.L83I; 2:201186024-201186024	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1508C>A; p.P503H; 2:201217680-201217680	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.536C>T; p.P179L; 2:201193078-201193078	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.321C>T; p.P107P; 2:201186098-201186098	skin	malignant_melanoma	Substitution - coding silent
c.174C>A; p.A58A; 2:201185951-201185951	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.1038C>T; p.A346A; 2:201209185-201209185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1466G>A; p.R489Q; 2:201217638-201217638	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.259C>T; p.R87W; 2:201186036-201186036	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>G; p.F77L; 2:201186008-201186008	liver	carcinoma	Substitution - Missense
c.1100C>T; p.S367L; 2:201209247-201209247	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>G; p.F77L; 2:201186008-201186008	liver	carcinoma	Substitution - Missense
c.346A>T; p.R116*; 2:201186123-201186123	prostate	carcinoma	Substitution - Nonsense
c.928C>T; p.L310L; 2:201209075-201209075	skin	malignant_melanoma	Substitution - coding silent
c.361G>A; p.E121K; 2:201187719-201187719	skin	malignant_melanoma	Substitution - Missense
c.1313T>G; p.L438R; 2:201209460-201209460	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.64G>T; p.E22*; 2:201185841-201185841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1308C>T; p.F436F; 2:201209455-201209455	skin	malignant_melanoma	Substitution - coding silent
c.3G>T; p.M1I; 2:201185780-201185780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.106G>A; p.V36M; 2:201185883-201185883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.593C>A; p.T198K; 2:201195857-201195857	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.993A>G; p.E331E; 2:201209140-201209140	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1366A>G; p.S456G; 2:201209513-201209513	pancreas	NS	Substitution - Missense
c.1195C>T; p.Q399*; 2:201209342-201209342	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.717T>C; p.S239S; 2:201203762-201203762	skin	malignant_melanoma	Substitution - coding silent
c.717T>C; p.S239S; 2:201203762-201203762	skin	malignant_melanoma	Substitution - coding silent
c.347+1G>A; p.?; 2:201186125-201186125	stomach	carcinoma; adenocarcinoma	Unknown
c.903A>C; p.Q301H; 2:201208164-201208164	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.61C>T; p.R21C; 2:201185838-201185838	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1344C>T; p.S448S; 2:201209491-201209491	skin	malignant_melanoma	Substitution - coding silent
c.419A>T; p.D140V; 2:201187777-201187777	pancreas	carcinoma	Substitution - Missense
c.419A>T; p.D140V; 2:201187777-201187777	pancreas	carcinoma	Substitution - Missense
c.1227C>T; p.S409S; 2:201209374-201209374	skin	malignant_melanoma	Substitution - coding silent
c.1258G>A; p.E420K; 2:201209405-201209405	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.423G>A; p.S141S; 2:201187781-201187781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329C>A; p.V443V; 2:201209476-201209476	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1419T>C; p.H473H; 2:201217591-201217591	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.816G>A; p.R272R; 2:201208077-201208077	skin	malignant_melanoma	Substitution - coding silent
c.1065T>C; p.I355I; 2:201209212-201209212	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.177A>G; p.S59S; 2:201185954-201185954	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.289T>C; p.C97R; 2:201186066-201186066	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.725A>C; p.N242T; 2:201205885-201205885	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>A; p.E68K; 2:201185979-201185979	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.66G>T; p.E22D; 2:201185843-201185843	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1053C>T; p.F351F; 2:201209200-201209200	skin	malignant_melanoma	Substitution - coding silent
c.1398G>A; p.L466L; 2:201209545-201209545	skin	malignant_melanoma	Substitution - coding silent
c.922+1G>A; p.?; 2:201208184-201208184	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1412C>A; p.P471Q; 2:201209559-201209559	skin	malignant_melanoma	Substitution - Missense
c.927C>T; p.I309I; 2:201209074-201209074	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.95G>A; p.G32E; 2:201185872-201185872	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.285C>A; p.L95L; 2:201186062-201186062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.755T>C; p.V252A; 2:201205915-201205915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755T>C; p.V252A; 2:201205915-201205915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755T>C; p.V252A; 2:201205915-201205915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1487C>G; p.T496R; 2:201217659-201217659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1452C>T; p.N484N; 2:201217624-201217624	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1393C>G; p.H465D; 2:201209540-201209540	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.620C>T; p.S207L; 2:201195884-201195884	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.357C>T; p.L119L; 2:201187715-201187715	skin	malignant_melanoma	Substitution - coding silent
c.1420G>A; p.E474K; 2:201217592-201217592	skin	malignant_melanoma	Substitution - Missense
c.1262A>T; p.Q421L; 2:201209409-201209409	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1202_1208delGCCAAGG; p.C401fs*15; 2:201209349-201209355	breast	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.1065T>A; p.I355I; 2:201209212-201209212	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.159G>C; p.E53D; 2:201185936-201185936	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3G>A; p.M1I; 2:201185780-201185780	breast	carcinoma	Substitution - Missense
c.1237G>A; p.E413K; 2:201209384-201209384	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1237G>A; p.E413K; 2:201209384-201209384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1357G>A; p.E453K; 2:201209504-201209504	skin	malignant_melanoma	Substitution - Missense
c.1274C>T; p.S425F; 2:201209421-201209421	skin	malignant_melanoma	Substitution - Missense
c.1117C>G; p.P373A; 2:201209264-201209264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984G>A; p.T328T; 2:201209131-201209131	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.984G>A; p.T328T; 2:201209131-201209131	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>A; p.T328T; 2:201209131-201209131	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.984G>A; p.T328T; 2:201209131-201209131	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.889C>T; p.L297L; 2:201208150-201208150	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation