lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	83933
Symbol	HDAC10
Synonymous	HD10
Full name	histone deacetylase 10
Gene description	-
Cytoband	22q13.31
Gene type	protein-coding
Synonymous	MIM:608544; HGNC:HGNC:18128; Ensembl:ENSG00000100429; HPRD:09407; Vega:OTTHUMG00000044647

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1324G>A; p.E442K; 22:50247903-50247903	skin	malignant_melanoma	Substitution - Missense
c.1324G>A; p.E442K; 22:50247903-50247903	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1317G>A; p.E439E; 22:50247910-50247910	skin	malignant_melanoma	Substitution - coding silent
c.546C>G; p.L182L; 22:50249652-50249652	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.750C>T; p.A250A; 22:50249109-50249109	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1132C>A; p.P378T; 22:50248095-50248095	thyroid	other; neoplasm	Substitution - Missense
c.195-10C>T; p.?; 22:50250533-50250533	breast	carcinoma	Unknown
c.1753C>G; p.L585V; 22:50245990-50245990	breast	carcinoma	Substitution - Missense
c.460G>A; p.A154T; 22:50249894-50249894	thyroid	other; neoplasm	Substitution - Missense
c.1569C>T; p.D523D; 22:50246681-50246681	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.240_241GG>AA; p.E81K; 22:50250477-50250478	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1128G>A; p.G376G; 22:50248099-50248099	skin	malignant_melanoma	Substitution - coding silent
c.1554A>G; p.P518P; 22:50246696-50246696	liver	carcinoma	Substitution - coding silent
c.782C>T; p.S261L; 22:50248865-50248865	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1678T>C; p.L560L; 22:50246065-50246065	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.797C>G; p.S266*; 22:50248850-50248850	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.797C>G; p.S266*; 22:50248850-50248850	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.337C>T; p.L113L; 22:50250115-50250115	prostate	carcinoma	Substitution - coding silent
c.310C>T; p.R104W; 22:50250142-50250142	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1357C>T; p.R453W; 22:50247757-50247757	oesophagus	carcinoma	Substitution - Missense
c.291G>A; p.P97P; 22:50250427-50250427	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1360G>A; p.E454K; 22:50247754-50247754	skin	malignant_melanoma	Substitution - Missense
c.1055C>A; p.P352Q; 22:50248251-50248251	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.975G>A; p.P325P; 22:50248404-50248404	thyroid	carcinoma	Substitution - coding silent
c.1948C>A; p.L650M; 22:50245713-50245713	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.465A>T; p.A155A; 22:50249889-50249889	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1075C>T; p.Q359*; 22:50248231-50248231	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1613C>T; p.A538V; 22:50246335-50246335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.847G>A; p.A283T; 22:50248721-50248721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>A; p.G273G; 22:50248749-50248749	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1525G>A; p.V509M; 22:50246725-50246725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1039C>T; p.R347C; 22:50248267-50248267	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>G; p.Q337E; 22:50248370-50248370	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1231C>G; p.R411G; 22:50247996-50247996	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1090G>A; p.A364T; 22:50248137-50248137	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.167C>G; p.S56W; 22:50250798-50250798	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1168G>A; p.A390T; 22:50248059-50248059	skin	malignant_melanoma	Substitution - Missense
c.1082-1G>T; p.?; 22:50248146-50248146	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.754G>C; p.E252Q; 22:50249105-50249105	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.336G>A; p.Q112Q; 22:50250116-50250116	breast	carcinoma	Substitution - coding silent
c.1301C>T; p.A434V; 22:50247926-50247926	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1270G>A; p.V424I; 22:50247957-50247957	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.948G>A; p.M316I; 22:50248431-50248431	skin	malignant_melanoma	Substitution - Missense
c.5G>A; p.G2E; 22:50251028-50251028	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>T; p.T278M; 22:50248735-50248735	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>T; p.T278M; 22:50248735-50248735	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1757A>G; p.Q586R; 22:50245986-50245986	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1315G>A; p.E439K; 22:50247912-50247912	skin	malignant_melanoma	Substitution - Missense
c.1362G>A; p.E454E; 22:50247752-50247752	skin	malignant_melanoma	Substitution - coding silent
c.913T>A; p.Y305N; 22:50248466-50248466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.274G>A; p.A92T; 22:50250444-50250444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.880G>A; p.G294S; 22:50248688-50248688	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.834G>A; p.T278T; 22:50248734-50248734	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.834G>A; p.T278T; 22:50248734-50248734	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.46C>A; p.L16M; 22:50250987-50250987	central_nervous_system; brain	glioma	Substitution - Missense
c.1414delG; p.D472fs*4; 22:50247700-50247700	autonomic_ganglia	neuroblastoma	Deletion - Frameshift
c.1174G>A; p.A392T; 22:50248053-50248053	skin	malignant_melanoma	Substitution - Missense
c.1608G>A; p.A536A; 22:50246340-50246340	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1570G>A; p.G524R; 22:50246680-50246680	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1460C>T; p.A487V; 22:50246929-50246929	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1546C>A; p.R516R; 22:50246704-50246704	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1055C>T; p.P352L; 22:50248251-50248251	pancreas	carcinoma	Substitution - Missense
c.1365G>T; p.E455D; 22:50247749-50247749	liver	carcinoma	Substitution - Missense
c.1365G>T; p.E455D; 22:50247749-50247749	liver	carcinoma	Substitution - Missense
c.1033A>C; p.S345R; 22:50248273-50248273	liver	carcinoma	Substitution - Missense
c.1033A>C; p.S345R; 22:50248273-50248273	liver	carcinoma	Substitution - Missense
c.1598delG; p.G533fs*18; 22:50246350-50246350	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.20A>T; p.Y7F; 22:50251013-50251013	NS	malignant_melanoma	Substitution - Missense
c.944G>A; p.C315Y; 22:50248435-50248435	skin	malignant_melanoma	Substitution - Missense
c.20A>T; p.Y7F; 22:50251013-50251013	NS	malignant_melanoma	Substitution - Missense
c.1993C>T; p.P665S; 22:50245524-50245524	skin	malignant_melanoma	Substitution - Missense
c.1595delG; p.G533fs*18; 22:50246353-50246353	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.558C>G; p.D186E; 22:50249640-50249640	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1464A>G; p.A488A; 22:50246925-50246925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1634C>G; p.S545C; 22:50246314-50246314	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1338-1G>T; p.?; 22:50247777-50247777	stomach	carcinoma; adenocarcinoma	Unknown
c.818G>A; p.G273E; 22:50248750-50248750	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1439C>T; p.A480V; 22:50246950-50246950	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1626C>G; p.F542L; 22:50246322-50246322	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.601C>T; p.R201C; 22:50249417-50249417	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1131G>A; p.R377R; 22:50248096-50248096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.817G>T; p.G273W; 22:50248751-50248751	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1469C>T; p.T490I; 22:50246920-50246920	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.430T>C; p.F144L; 22:50249924-50249924	liver	carcinoma	Substitution - Missense
c.1657G>A; p.G553S; 22:50246086-50246086	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1747C>A; p.H583N; 22:50245996-50245996	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1174G>T; p.A392S; 22:50248053-50248053	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation