Cancer metastasis database

Annotation category 5

Gene information

Gene ID 836
Symbol

CASP3

Synonymous

CPP32|CPP32B|SCA-1

Full name

caspase 3, apoptosis-related cysteine peptidase

Gene description

CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama

Cytoband

4q34

Gene type

protein-coding

Synonymous

MIM:600636; HGNC:HGNC:1504; Ensembl:ENSG00000164305; HPRD:02799; Vega:OTTHUMG00000133681

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.428T>C; p.F143S; 4:184631820-184631820

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.721C>T; p.R241*; 4:184629385-184629385

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.308-1G>T; p.?; 4:184631941-184631941

 kidneyother; neoplasmUnknown

c.385G>T; p.G129*; 4:184631863-184631863

 skin; earcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.197G>T; p.G66V; 4:184632378-184632378

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.702C>A; p.H234Q; 4:184629404-184629404

 livercarcinomaSubstitution - Missense

c.295T>A; p.L99M; 4:184632280-184632280

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.347G>A; p.C116Y; 4:184631901-184631901

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.340T>G; p.F114V; 4:184631908-184631908

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.415A>G; p.I139V; 4:184631833-184631833

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.825T>A; p.F275L; 4:184629281-184629281

 prostatecarcinomaSubstitution - Missense

c.52C>T; p.P18S; 4:184638402-184638402

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.574G>A; p.D192N; 4:184631067-184631067

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.429C>T; p.F143F; 4:184631819-184631819

 skinmalignant_melanomaSubstitution - coding silent

c.429C>T; p.F143F; 4:184631819-184631819

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.801C>A; p.S267S; 4:184629305-184629305

 skinmalignant_melanomaSubstitution - coding silent

c.657T>C; p.L219L; 4:184629449-184629449

 skinmalignant_melanomaSubstitution - coding silent

c.321T>C; p.D107D; 4:184631927-184631927

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.301C>T; p.R101C; 4:184632274-184632274

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.549G>A; p.A183A; 4:184631092-184631092

 skinmalignant_melanomaSubstitution - coding silent

c.482A>T; p.Q161L; 4:184631766-184631766

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.78A>G; p.S26S; 4:184635394-184635394

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.619C>T; p.R207*; 4:184629487-184629487

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.483+1G>A; p.?; 4:184631764-184631764

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.439C>T; p.R147C; 4:184631809-184631809

 skinmalignant_melanomaSubstitution - Missense

c.573C>A; p.A191A; 4:184631068-184631068

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.645C>T; p.F215F; 4:184629461-184629461

 thyroidcarcinomaSubstitution - coding silent

c.159G>T; p.K53N; 4:184635313-184635313

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.538G>C; p.D180H; 4:184631103-184631103

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.191G>A; p.R64Q; 4:184632384-184632384

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.831C>G; p.H277Q; 4:184629275-184629275

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.72C>T; p.S24S; 4:184635400-184635400

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.352C>A; p.L118I; 4:184631896-184631896

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.814G>T; p.E272*; 4:184629292-184629292

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.814G>T; p.E272*; 4:184629292-184629292

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.814G>T; p.E272*; 4:184629292-184629292

 breastcarcinomaSubstitution - Nonsense

c.343G>T; p.V115F; 4:184631905-184631905

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.481C>T; p.Q161*; 4:184631767-184631767

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.415delA; p.I139fs*1; 4:184631833-184631833

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.207C>T; p.V69V; 4:184632368-184632368

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.207C>T; p.V69V; 4:184632368-184632368

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.491G>A; p.R164H; 4:184631150-184631150

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.3G>A; p.M1I; 4:184638451-184638451

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.268G>T; p.D90Y; 4:184632307-184632307

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.188C>T; p.S63F; 4:184632387-184632387

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.542A>C; p.D181A; 4:184631099-184631099

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.712C>T; p.R238W; 4:184629394-184629394

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.730G>A; p.A244T; 4:184629376-184629376

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense