lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	81930
Symbol	KIF18A
Synonymous	MS-KIF18A\|PPP1R99
Full name	kinesin family member 18A
Gene description	kinesin-like protein KIF18A\|protein phosphatase 1, regulatory subunit 99
Cytoband	11p14.1
Gene type	protein-coding
Synonymous	MIM:611271; HGNC:HGNC:29441; Ensembl:ENSG00000121621; HPRD:11177; Vega:OTTHUMG00000166195

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.171G>T; p.K57N; 11:28097777-28097777	breast	carcinoma	Substitution - Missense
c.539G>T; p.R180L; 11:28091458-28091458	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1485G>A; p.E495E; 11:28069364-28069364	skin	malignant_melanoma	Substitution - coding silent
c.49C>T; p.R17C; 11:28097899-28097899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.49C>T; p.R17C; 11:28097899-28097899	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.689C>A; p.A230D; 11:28090627-28090627	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.921C>T; p.Y307Y; 11:28084785-28084785	prostate	adenoma	Substitution - coding silent
c.49C>T; p.R17C; 11:28097899-28097899	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.49C>T; p.R17C; 11:28097899-28097899	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.555delA; p.V187fs*35; 11:28091442-28091442	thyroid	carcinoma; anaplastic_carcinoma	Deletion - Frameshift
c.555delA; p.V187fs*35; 11:28091442-28091442	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1881C>G; p.N627K; 11:28058993-28058993	oesophagus	carcinoma	Substitution - Missense
c.1956T>G; p.S652S; 11:28036657-28036657	skin	malignant_melanoma	Substitution - coding silent
c.1575C>T; p.N525N; 11:28069274-28069274	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.197A>C; p.K66T; 11:28097751-28097751	skin	malignant_melanoma	Substitution - Missense
c.1257C>T; p.I419I; 11:28082861-28082861	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1297C>T; p.R433*; 11:28077135-28077135	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.782G>T; p.G261V; 11:28088639-28088639	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.31C>T; p.H11Y; 11:28097917-28097917	skin	malignant_melanoma	Substitution - Missense
c.2263C>T; p.H755Y; 11:28036350-28036350	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2205C>T; p.I735I; 11:28036408-28036408	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1947T>C; p.C649C; 11:28058927-28058927	liver	carcinoma	Substitution - coding silent
c.1947T>C; p.C649C; 11:28058927-28058927	liver	carcinoma	Substitution - coding silent
c.211G>A; p.D71N; 11:28097737-28097737	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2041A>T; p.T681S; 11:28036572-28036572	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.100G>A; p.V34I; 11:28097848-28097848	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1497G>T; p.E499D; 11:28069352-28069352	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1570C>A; p.Q524K; 11:28069279-28069279	kidney	other; neoplasm	Substitution - Missense
c.1207G>A; p.E403K; 11:28082911-28082911	skin	malignant_melanoma	Substitution - Missense
c.721A>G; p.K241E; 11:28088700-28088700	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.956C>A; p.S319Y; 11:28084750-28084750	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2104C>T; p.P702S; 11:28036509-28036509	breast	carcinoma	Substitution - Missense
c.2517C>G; p.N839K; 11:28023838-28023838	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1545C>T; p.V515V; 11:28069304-28069304	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1949-1G>T; p.?; 11:28036665-28036665	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.791G>A; p.R264Q; 11:28088630-28088630	skin	malignant_melanoma	Substitution - Missense
c.2125G>C; p.D709H; 11:28036488-28036488	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1054G>A; p.A352T; 11:28084652-28084652	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2203A>G; p.I735V; 11:28036410-28036410	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2151G>A; p.P717P; 11:28036462-28036462	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2118A>T; p.T706T; 11:28036495-28036495	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2084C>A; p.S695Y; 11:28036529-28036529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2151G>A; p.P717P; 11:28036462-28036462	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1812C>T; p.I604I; 11:28059062-28059062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1070C>T; p.S357F; 11:28084636-28084636	skin; neck	malignant_melanoma	Substitution - Missense
c.149_151delAAG; p.E50delE; 11:28097797-28097799	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.2336C>T; p.S779L; 11:28036277-28036277	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2019A>T; p.P673P; 11:28036594-28036594	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1801T>A; p.F601I; 11:28059073-28059073	kidney	other; neoplasm	Substitution - Missense
c.32A>G; p.H11R; 11:28097916-28097916	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2147A>G; p.N716S; 11:28036466-28036466	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.419T>G; p.L140R; 11:28094707-28094707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1152T>G; p.I384M; 11:28082966-28082966	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1468C>T; p.R490C; 11:28069381-28069381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.547A>G; p.T183A; 11:28091450-28091450	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2003G>A; p.R668Q; 11:28036610-28036610	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2109T>C; p.I703I; 11:28036504-28036504	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2522C>T; p.S841L; 11:28023833-28023833	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2522C>T; p.S841L; 11:28023833-28023833	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2522C>T; p.S841L; 11:28023833-28023833	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2219A>G; p.N740S; 11:28036394-28036394	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1663_1664delAT; p.M555fs*15; 11:28062443-28062444	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1980G>A; p.K660K; 11:28036633-28036633	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1632G>A; p.Q544Q; 11:28062475-28062475	breast	carcinoma	Substitution - coding silent
c.1263-2A>T; p.?; 11:28077171-28077171	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.524G>T; p.G175V; 11:28091473-28091473	liver	carcinoma	Substitution - Missense
c.524G>T; p.G175V; 11:28091473-28091473	liver	carcinoma	Substitution - Missense
c.853C>A; p.L285I; 11:28088568-28088568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1482G>A; p.L494L; 11:28069367-28069367	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.320G>T; p.C107F; 11:28097628-28097628	breast	carcinoma	Substitution - Missense
c.1213G>A; p.D405N; 11:28082905-28082905	urinary_tract; bladder	carcinoma	Substitution - Missense
c.248C>T; p.T83M; 11:28097700-28097700	meninges	meningioma; secretory	Substitution - Missense
c.565G>A; p.V189I; 11:28091432-28091432	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.225A>G; p.V75V; 11:28097723-28097723	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2572A>C; p.N858H; 11:28023783-28023783	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1090C>G; p.L364V; 11:28083228-28083228	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.2543C>A; p.S848Y; 11:28023812-28023812	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1617_1618CC>TT; p.H540Y; 11:28062489-28062490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1052G>A; p.R351Q; 11:28084654-28084654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1570C>G; p.Q524E; 11:28069279-28069279	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1516G>C; p.D506H; 11:28069333-28069333	urinary_tract; bladder	carcinoma	Substitution - Missense
c.157T>A; p.F53I; 11:28097791-28097791	kidney	other; neoplasm	Substitution - Missense
c.1896T>A; p.I632I; 11:28058978-28058978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2558delG; p.R853fs*28; 11:28023797-28023797	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.965G>T; p.G322V; 11:28084741-28084741	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1362A>G; p.S454S; 11:28077070-28077070	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.617T>G; p.L206*; 11:28090699-28090699	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Nonsense
c.617T>G; p.L206*; 11:28090699-28090699	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Nonsense
c.2273G>A; p.R758K; 11:28036340-28036340	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2674A>G; p.I892V; 11:28021223-28021223	breast	carcinoma	Substitution - Missense
c.1218A>G; p.Q406Q; 11:28082900-28082900	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.59C>G; p.P20R; 11:28097889-28097889	skin; leg	malignant_melanoma; nodular	Substitution - Missense
c.1204A>G; p.N402D; 11:28082914-28082914	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1509G>C; p.K503N; 11:28069340-28069340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.273A>G; p.E91E; 11:28097675-28097675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.614A>G; p.H205R; 11:28090702-28090702	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2146A>T; p.N716Y; 11:28036467-28036467	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.383A>G; p.D128G; 11:28094743-28094743	liver	carcinoma	Substitution - Missense
c.502C>T; p.R168C; 11:28091495-28091495	oesophagus	carcinoma	Substitution - Missense
c.502C>T; p.R168C; 11:28091495-28091495	skin	malignant_melanoma	Substitution - Missense
c.502C>T; p.R168C; 11:28091495-28091495	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.493G>A; p.E165K; 11:28091504-28091504	breast	carcinoma	Substitution - Missense
c.539G>A; p.R180Q; 11:28091458-28091458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1363T>G; p.F455V; 11:28077069-28077069	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1881C>T; p.N627N; 11:28058993-28058993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1741A>G; p.R581G; 11:28059133-28059133	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2177C>T; p.S726L; 11:28036436-28036436	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.59C>T; p.P20L; 11:28097889-28097889	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1298G>A; p.R433Q; 11:28077134-28077134	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.103C>A; p.H35N; 11:28097845-28097845	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1017C>T; p.Y339Y; 11:28084689-28084689	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180T>A; p.Y394N; 11:28082938-28082938	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.240delT; p.F80fs*23; 11:28097708-28097708	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1546G>A; p.E516K; 11:28069303-28069303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1546G>A; p.E516K; 11:28069303-28069303	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2536G>A; p.V846I; 11:28023819-28023819	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1591-2A>G; p.?; 11:28062518-28062518	lung	carcinoma; adenocarcinoma	Unknown
c.2535C>T; p.D845D; 11:28023820-28023820	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2088T>C; p.L696L; 11:28036525-28036525	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1910C>T; p.T637I; 11:28058964-28058964	skin	malignant_melanoma	Substitution - Missense
c.233C>A; p.A78D; 11:28097715-28097715	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1495G>T; p.E499*; 11:28069354-28069354	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2457C>T; p.S819S; 11:28035434-28035434	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1374A>G; p.Q458Q; 11:28077058-28077058	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2557C>T; p.R853C; 11:28023798-28023798	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1374A>G; p.Q458Q; 11:28077058-28077058	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.817A>T; p.T273S; 11:28088604-28088604	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1769C>T; p.A590V; 11:28059105-28059105	skin	malignant_melanoma	Substitution - Missense
c.1025delC; p.T342fs*18; 11:28084681-28084681	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.474A>G; p.S158S; 11:28094652-28094652	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2160A>G; p.V720V; 11:28036453-28036453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2229T>G; p.N743K; 11:28036384-28036384	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.588+2T>A; p.?; 11:28091407-28091407	skin	malignant_melanoma	Unknown
c.2050T>G; p.S684A; 11:28036563-28036563	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>T; p.R237*; 11:28088712-28088712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1367A>G; p.Y456C; 11:28077065-28077065	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1469G>A; p.R490H; 11:28069380-28069380	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2693G>C; p.R898T; 11:28021204-28021204	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2424G>C; p.K808N; 11:28035467-28035467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.E146K; 11:28094690-28094690	breast	carcinoma	Substitution - Missense
c.2285G>A; p.G762E; 11:28036328-28036328	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2556A>T; p.K852N; 11:28023799-28023799	urinary_tract; bladder	carcinoma	Substitution - Missense
c.570T>C; p.H190H; 11:28091427-28091427	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1724C>T; p.A575V; 11:28059150-28059150	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2456C>G; p.S819C; 11:28035435-28035435	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1420G>C; p.E474Q; 11:28077012-28077012	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2325C>T; p.D775D; 11:28036288-28036288	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.19G>C; p.D7H; 11:28097929-28097929	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1005C>T; p.S335S; 11:28084701-28084701	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.395T>G; p.V132G; 11:28094731-28094731	skin	malignant_melanoma	Substitution - Missense
c.564C>T; p.V188V; 11:28091433-28091433	skin	malignant_melanoma	Substitution - coding silent
c.2491C>T; p.R831W; 11:28035400-28035400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2491C>T; p.R831W; 11:28035400-28035400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2242T>C; p.L748L; 11:28036371-28036371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1244A>G; p.Q415R; 11:28082874-28082874	liver	carcinoma	Substitution - Missense
c.1996_1997insA; p.R666fs*29; 11:28036616-28036617	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2057C>T; p.P686L; 11:28036556-28036556	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1309A>G; p.R437G; 11:28077123-28077123	liver	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation