lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	81839
Symbol	VANGL1
Synonymous	KITENIN\|LPP2\|STB2\|STBM2
Full name	VANGL planar cell polarity protein 1
Gene description	KAI1 C-terminal interacting tetraspanin\|loop-tail protein 2 homolog\|strabismus 2\|van Gogh-like protein 1\|vang-like 1 (van gogh, Drosophila)\|vang-like protein 1
Cytoband	1p13.1
Gene type	protein-coding
Synonymous	MIM:610132; HGNC:HGNC:15512; Ensembl:ENSG00000173218; HPRD:18279; Vega:OTTHUMG00000011971

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1011_1013delCTC; p.D337_S338>E; 1:115684008-115684010	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Complex - deletion inframe
c.1011_1013delCTC; p.D337_S338>E; 1:115684008-115684010	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Complex - deletion inframe
c.882C>T; p.L294L; 1:115682433-115682433	skin	malignant_melanoma	Substitution - coding silent
c.1245G>A; p.Q415Q; 1:115685458-115685458	skin	malignant_melanoma	Substitution - coding silent
c.685G>A; p.A229T; 1:115664141-115664141	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1056G>T; p.R352R; 1:115684053-115684053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.203A>G; p.Q68R; 1:115659772-115659772	skin	malignant_melanoma	Substitution - Missense
c.1358A>T; p.Y453F; 1:115691162-115691162	lung	carcinoid-endocrine_tumour; atypical	Substitution - Missense
c.509delT; p.F172fs*99; 1:115663965-115663965	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.605delT; p.Y204fs*67; 1:115664061-115664061	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.635G>A; p.R212Q; 1:115664091-115664091	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.509delT; p.F172fs*99; 1:115663965-115663965	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.509delT; p.F172fs*99; 1:115663965-115663965	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.635G>A; p.R212Q; 1:115664091-115664091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.509delT; p.F172fs*99; 1:115663965-115663965	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.325C>T; p.R109C; 1:115663781-115663781	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.L113L; 1:115663795-115663795	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.529G>C; p.A177P; 1:115663985-115663985	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.318T>A; p.D106E; 1:115663774-115663774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.922G>T; p.G308W; 1:115682473-115682473	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.922G>T; p.G308W; 1:115682473-115682473	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1384C>T; p.Q462*; 1:115691188-115691188	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1384C>T; p.Q462*; 1:115691188-115691188	large_intestine; colon	carcinoma	Substitution - Nonsense
c.1379C>T; p.S460F; 1:115691183-115691183	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.556C>T; p.R186C; 1:115664012-115664012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.713T>A; p.I238N; 1:115664169-115664169	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.390C>T; p.F130F; 1:115663846-115663846	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.390C>T; p.F130F; 1:115663846-115663846	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.359G>A; p.G120E; 1:115663815-115663815	NS	NS	Substitution - Missense
c.799C>T; p.L267L; 1:115664255-115664255	oesophagus	carcinoma	Substitution - coding silent
c.230C>T; p.T77M; 1:115663686-115663686	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.682G>C; p.D228H; 1:115664138-115664138	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1001G>A; p.R334Q; 1:115683998-115683998	breast	carcinoma	Substitution - Missense
c.1543G>T; p.V515F; 1:115691347-115691347	breast	carcinoma	Substitution - Missense
c.926T>A; p.L309Q; 1:115682477-115682477	skin	malignant_melanoma	Substitution - Missense
c.1493C>A; p.P498Q; 1:115691297-115691297	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1228C>T; p.R410C; 1:115685441-115685441	skin	malignant_melanoma	Substitution - Missense
c.962C>T; p.A321V; 1:115683959-115683959	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1004G>A; p.R335H; 1:115684001-115684001	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	thyroid	other; neoplasm	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1013C>A; p.S338*; 1:115684010-115684010	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1426C>T; p.R476W; 1:115691230-115691230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.259A>T; p.I87L; 1:115663715-115663715	pancreas	carcinoma	Substitution - Missense
c.1009G>T; p.D337Y; 1:115684006-115684006	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1007G>T; p.R336M; 1:115684004-115684004	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.496G>T; p.G166W; 1:115663952-115663952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1030T>C; p.Y344H; 1:115684027-115684027	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>A; p.A275T; 1:115682374-115682374	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>T; p.W168C; 1:115663960-115663960	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.393C>T; p.I131I; 1:115663849-115663849	skin	malignant_melanoma	Substitution - coding silent
c.1266C>A; p.S422R; 1:115685479-115685479	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1039G>T; p.E347*; 1:115684036-115684036	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.76A>T; p.R26*; 1:115659645-115659645	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.921C>A; p.A307A; 1:115682472-115682472	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1179C>T; p.A393A; 1:115685392-115685392	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1165G>T; p.D389Y; 1:115685378-115685378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.634C>T; p.R212W; 1:115664090-115664090	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.72G>A; p.G24G; 1:115659641-115659641	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.634C>T; p.R212W; 1:115664090-115664090	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1080G>T; p.R360S; 1:115685293-115685293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.191C>A; p.T64K; 1:115659760-115659760	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058G>A; p.R353Q; 1:115684055-115684055	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.77G>C; p.R26T; 1:115659646-115659646	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.773C>T; p.T258I; 1:115664229-115664229	skin	malignant_melanoma	Substitution - Missense
c.182C>A; p.S61Y; 1:115659751-115659751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1471G>T; p.V491L; 1:115691275-115691275	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.498G>T; p.G166G; 1:115663954-115663954	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.701A>G; p.H234R; 1:115664157-115664157	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.L231F; 1:115664147-115664147	urinary_tract; bladder	carcinoma	Substitution - Missense
c.346G>A; p.A116T; 1:115663802-115663802	skin	malignant_melanoma	Substitution - Missense
c.346G>A; p.A116T; 1:115663802-115663802	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.346G>A; p.A116T; 1:115663802-115663802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1068G>T; p.K356N; 1:115684065-115684065	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.T126T; 1:115663834-115663834	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.244A>C; p.T82P; 1:115663700-115663700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1050T>C; p.H350H; 1:115684047-115684047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.725A>C; p.E242A; 1:115664181-115664181	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1057C>T; p.R353*; 1:115684054-115684054	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1057C>T; p.R353*; 1:115684054-115684054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.863C>T; p.T288I; 1:115682414-115682414	skin	malignant_melanoma	Substitution - Missense
c.421G>A; p.E141K; 1:115663877-115663877	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1321C>T; p.L441L; 1:115691125-115691125	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.752C>T; p.T251M; 1:115664208-115664208	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.542G>C; p.R181P; 1:115663998-115663998	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1294A>T; p.T432S; 1:115685507-115685507	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.295A>G; p.M99V; 1:115663751-115663751	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.315_316GG>TT; p.D106Y; 1:115663771-115663772	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1549C>T; p.R517C; 1:115691353-115691353	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1237C>T; p.R413W; 1:115685450-115685450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.S199F; 1:115664052-115664052	skin	malignant_melanoma	Substitution - Missense
c.403C>T; p.P135S; 1:115663859-115663859	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1248C>A; p.N416K; 1:115685461-115685461	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.178G>A; p.D60N; 1:115659747-115659747	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.508_529del22; p.F171fs*93; 1:115663964-115663985	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1194C>T; p.F398F; 1:115685407-115685407	skin	malignant_melanoma	Substitution - coding silent
c.604_605insT; p.Y204fs*88; 1:115664060-115664061	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.178G>T; p.D60Y; 1:115659747-115659747	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.814A>G; p.I272V; 1:115682365-115682365	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.114C>T; p.D38D; 1:115659683-115659683	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.682G>A; p.D228N; 1:115664138-115664138	breast	carcinoma	Substitution - Missense
c.618C>T; p.V206V; 1:115664074-115664074	skin	malignant_melanoma	Substitution - coding silent
c.618C>T; p.V206V; 1:115664074-115664074	skin	malignant_melanoma	Substitution - coding silent
c.524G>A; p.R175Q; 1:115663980-115663980	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1174G>A; p.E392K; 1:115685387-115685387	skin; mucosal	malignant_melanoma	Substitution - Missense
c.233C>T; p.A78V; 1:115663689-115663689	central_nervous_system; brain	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.1017C>T; p.S339S; 1:115684014-115684014	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation