lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	81671
Symbol	VMP1
Synonymous	EPG3\|TANGO5\|TMEM49
Full name	vacuole membrane protein 1
Gene description	ectopic P-granules autophagy protein 3 homolog\|transmembrane protein 49\|transport and golgi organization 5 homolog
Cytoband	17q23.1
Gene type	protein-coding
Synonymous	MIM:611753; HGNC:HGNC:29559; Ensembl:ENSG00000062716; HPRD:15649; Vega:OTTHUMG00000179882

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.579G>C; p.M193I; 17:59765135-59765135	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.637C>T; p.R213C; 17:59773808-59773808	liver	carcinoma	Substitution - Missense
c.637C>T; p.R213C; 17:59773808-59773808	liver	carcinoma	Substitution - Missense
c.44T>C; p.M15T; 17:59731490-59731490	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1079G>C; p.G360A; 17:59839769-59839769	central_nervous_system; posterior_fossa	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1045C>A; p.L349I; 17:59838365-59838365	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1020G>A; p.E340E; 17:59838340-59838340	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1081G>C; p.E361Q; 17:59839771-59839771	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.769delT; p.F258fs*19; 17:59808850-59808850	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1035A>G; p.Q345Q; 17:59838355-59838355	breast	carcinoma	Substitution - coding silent
c.805C>T; p.P269S; 17:59811679-59811679	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1015C>T; p.Q339*; 17:59838335-59838335	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1015C>T; p.Q339*; 17:59838335-59838335	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1038G>A; p.R346R; 17:59838358-59838358	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.105G>T; p.R35S; 17:59735366-59735366	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.353G>T; p.G118V; 17:59738886-59738886	liver	carcinoma	Substitution - Missense
c.864C>G; p.F288L; 17:59811738-59811738	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.81C>A; p.P27P; 17:59735342-59735342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.118G>A; p.E40K; 17:59735379-59735379	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.331C>A; p.L111I; 17:59738864-59738864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.331C>A; p.L111I; 17:59738864-59738864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.536C>T; p.S179F; 17:59765092-59765092	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.215T>C; p.L72S; 17:59737455-59737455	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.604G>A; p.E202K; 17:59773775-59773775	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1116C>T; p.V372V; 17:59839806-59839806	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1203_1204delAG; p.E402fs*4; 17:59839893-59839894	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.79C>A; p.P27T; 17:59735340-59735340	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.131T>G; p.I44S; 17:59735392-59735392	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1181G>A; p.R394Q; 17:59839871-59839871	central_nervous_system; posterior_fossa	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1116C>G; p.V372V; 17:59839806-59839806	breast	carcinoma	Substitution - coding silent
c.838C>T; p.H280Y; 17:59811712-59811712	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.631G>T; p.A211S; 17:59773802-59773802	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.991G>T; p.G331C; 17:59838311-59838311	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.864C>T; p.F288F; 17:59811738-59811738	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.775G>A; p.G259R; 17:59808856-59808856	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1077+2T>C; p.?; 17:59838399-59838399	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.223C>G; p.R75G; 17:59737463-59737463	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.632C>A; p.A211E; 17:59773803-59773803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.422A>T; p.H141L; 17:59764978-59764978	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1130G>T; p.C377F; 17:59839820-59839820	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.748A>C; p.K250Q; 17:59808829-59808829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.931A>G; p.T311A; 17:59817730-59817730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1094C>T; p.S365F; 17:59839784-59839784	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1036C>T; p.R346W; 17:59838356-59838356	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.213-1G>A; p.?; 17:59737452-59737452	skin; neck	malignant_melanoma	Unknown
c.1081G>A; p.E361K; 17:59839771-59839771	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>C; p.V187L; 17:59765115-59765115	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>A; p.P50P; 17:59735411-59735411	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.45G>A; p.M15I; 17:59731491-59731491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.830C>T; p.T277M; 17:59811704-59811704	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1005G>A; p.Q335Q; 17:59838325-59838325	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.371C>G; p.S124C; 17:59738904-59738904	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1215T>G; p.T405T; 17:59839905-59839905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.552C>T; p.I184I; 17:59765108-59765108	breast	carcinoma	Substitution - coding silent
c.971T>C; p.I324T; 17:59817770-59817770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.490G>A; p.D164N; 17:59765046-59765046	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.490G>A; p.D164N; 17:59765046-59765046	urinary_tract; bladder	carcinoma	Substitution - Missense
c.314G>A; p.R105H; 17:59738847-59738847	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.687G>T; p.E229D; 17:59773858-59773858	central_nervous_system; brain	glioma	Substitution - Missense
c.1101_1102insT; p.E369fs*1; 17:59839791-59839792	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.621C>T; p.F207F; 17:59773792-59773792	skin	malignant_melanoma	Substitution - coding silent
c.474C>T; p.P158P; 17:59765030-59765030	central_nervous_system; brain	glioma	Substitution - coding silent
c.1159A>G; p.M387V; 17:59839849-59839849	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.495G>C; p.Q165H; 17:59765051-59765051	thyroid	carcinoma	Substitution - Missense
c.495G>C; p.Q165H; 17:59765051-59765051	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1089G>T; p.W363C; 17:59839779-59839779	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1009C>T; p.P337S; 17:59838329-59838329	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.913-1G>A; p.?; 17:59817711-59817711	lung	carcinoma; adenocarcinoma	Unknown
c.1045C>T; p.L349F; 17:59838365-59838365	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1105G>C; p.E369Q; 17:59839795-59839795	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1105G>C; p.E369Q; 17:59839795-59839795	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1105G>C; p.E369Q; 17:59839795-59839795	central_nervous_system; posterior_fossa	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1105G>C; p.E369Q; 17:59839795-59839795	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.767G>C; p.G256A; 17:59808848-59808848	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.536C>A; p.S179Y; 17:59765092-59765092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.536C>A; p.S179Y; 17:59765092-59765092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.601G>A; p.G201R; 17:59773772-59773772	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation