lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	81567
Symbol	TXNDC5
Synonymous	ENDOPDI\|ERP46\|HCC-2\|PDIA15\|STRF8\|UNQ364
Full name	thioredoxin domain containing 5 (endoplasmic reticulum)
Gene description	ER protein 46\|endoplasmic reticulum protein ERp46\|endoplasmic reticulum resident protein 46\|endothelial protein disulphide isomerase\|protein disulfide isomerase family A, member 15\|thioredoxin domain-containing protein 5\|thioredoxin related protein\|thiore
Cytoband	6p24.3
Gene type	protein-coding
Synonymous	HGNC:HGNC:21073; Ensembl:ENSG00000239264; Ensembl:ENSG00000259040; HPRD:18249; Vega:OTTHUMG00000014216

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.593A>G; p.N198S; 6:7895129-7895129	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.593A>G; p.N198S; 6:7895129-7895129	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>A; p.A301E; 6:7888766-7888766	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1190C>T; p.P397L; 6:7883253-7883253	breast	carcinoma	Substitution - Missense
c.828G>C; p.Q276H; 6:7888840-7888840	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1035T>G; p.F345L; 6:7885972-7885972	breast	carcinoma	Substitution - Missense
c.264-1G>T; p.?; 6:7904724-7904724	lung	carcinoma; non_small_cell_carcinoma	Unknown
c.365C>T; p.T122M; 6:7904622-7904622	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.365C>T; p.T122M; 6:7904622-7904622	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1103T>C; p.F368S; 6:7884432-7884432	large_intestine; colon	carcinoma	Substitution - Missense
c.1103T>C; p.F368S; 6:7884432-7884432	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1004C>T; p.T335I; 6:7886003-7886003	skin	malignant_melanoma	Substitution - Missense
c.778C>T; p.R260C; 6:7889536-7889536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.289C>T; p.P97S; 6:7904698-7904698	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1175C>T; p.S392L; 6:7884360-7884360	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1175C>T; p.S392L; 6:7884360-7884360	skin; extremity	malignant_melanoma	Substitution - Missense
c.541_542CC>AT; p.P181>?; 6:7895180-7895181	skin; extremity	malignant_melanoma	Complex
c.291G>A; p.P97P; 6:7904696-7904696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.897T>G; p.T299T; 6:7888771-7888771	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1114G>A; p.A372T; 6:7884421-7884421	skin	malignant_melanoma	Substitution - Missense
c.1066C>G; p.L356V; 6:7884469-7884469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>T; p.E288*; 6:7888806-7888806	prostate	carcinoma	Substitution - Nonsense
c.1176G>A; p.S392S; 6:7884359-7884359	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1211G>A; p.G404E; 6:7883232-7883232	skin	malignant_melanoma	Substitution - Missense
c.426C>T; p.F142F; 6:7899669-7899669	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1207C>A; p.R403R; 6:7883236-7883236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.926A>G; p.E309G; 6:7888742-7888742	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.926A>G; p.E309G; 6:7888742-7888742	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.507C>G; p.N169K; 6:7899588-7899588	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.917C>T; p.T306M; 6:7888751-7888751	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.320A>G; p.N107S; 6:7904667-7904667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>C; p.E252Q; 6:7889560-7889560	breast	carcinoma	Substitution - Missense
c.759C>T; p.L253L; 6:7889555-7889555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>A; p.P215P; 6:7891708-7891708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.265T>C; p.C89R; 6:7904722-7904722	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.887G>A; p.R296H; 6:7888781-7888781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.315A>C; p.K105N; 6:7904672-7904672	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.430C>T; p.P144S; 6:7899665-7899665	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1207C>T; p.R403*; 6:7883236-7883236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1207C>T; p.R403*; 6:7883236-7883236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1207C>T; p.R403*; 6:7883236-7883236	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.805C>T; p.R269*; 6:7889509-7889509	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.1177G>A; p.V393I; 6:7883266-7883266	urinary_tract; bladder	carcinoma	Substitution - Missense
c.550G>A; p.A184T; 6:7895172-7895172	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.296G>A; p.W99*; 6:7904691-7904691	kidney	other; neoplasm	Substitution - Nonsense
c.550G>A; p.A184T; 6:7895172-7895172	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.271C>T; p.H91Y; 6:7904716-7904716	urinary_tract; bladder	carcinoma	Substitution - Missense
c.550G>A; p.A184T; 6:7895172-7895172	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.931C>T; p.P311S; 6:7888737-7888737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.302A>G; p.D101G; 6:7904685-7904685	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.644C>T; p.P215L; 6:7891709-7891709	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.644C>T; p.P215L; 6:7891709-7891709	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.P172S; 6:7899581-7899581	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1181G>A; p.R394Q; 6:7883262-7883262	pancreas	carcinoma	Substitution - Missense
c.920C>T; p.P307L; 6:7888748-7888748	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.619G>A; p.D207N; 6:7891734-7891734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.819+5G>A; p.?; 6:7889490-7889490	pancreas	carcinoma	Unknown
c.325A>G; p.M109V; 6:7904662-7904662	liver	carcinoma	Substitution - Missense
c.291G>T; p.P97P; 6:7904696-7904696	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.640G>A; p.A214T; 6:7891713-7891713	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.325A>G; p.M109V; 6:7904662-7904662	liver	carcinoma	Substitution - Missense
c.996C>T; p.F332F; 6:7886011-7886011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.516A>G; p.P172P; 6:7899579-7899579	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.650G>A; p.C217Y; 6:7891703-7891703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.842G>A; p.R281Q; 6:7888826-7888826	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.842G>A; p.R281Q; 6:7888826-7888826	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1291G>A; p.E431K; 6:7883152-7883152	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1291G>A; p.E431K; 6:7883152-7883152	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>T; p.T297I; 6:7888778-7888778	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.543G>A; p.P181P; 6:7895179-7895179	breast	carcinoma	Substitution - coding silent
c.1208G>A; p.R403Q; 6:7883235-7883235	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1208G>A; p.R403Q; 6:7883235-7883235	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.720C>T; p.V240V; 6:7891633-7891633	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.348G>T; p.V116V; 6:7904639-7904639	breast	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation