lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	80381
Symbol	CD276
Synonymous	4Ig-B7-H3\|B7-H3\|B7H3\|B7RP-2
Full name	CD276 molecule
Gene description	B7 homolog 3\|CD276 antigen\|costimulatory molecule
Cytoband	15q23-q24
Gene type	protein-coding
Synonymous	MIM:605715; HGNC:HGNC:19137; Ensembl:ENSG00000103855; HPRD:05756; Vega:OTTHUMG00000137585

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.733+4G>T; p.?; 15:73703090-73703090	stomach	carcinoma; adenocarcinoma	Unknown
c.785C>T; p.T262I; 15:73703710-73703710	skin	malignant_melanoma	Substitution - Missense
c.79G>A; p.G27R; 15:73699718-73699718	central_nervous_system; brain	glioma	Substitution - Missense
c.1138A>G; p.T380A; 15:73704241-73704241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1351G>A; p.G451S; 15:73704454-73704454	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.S324F; 15:73703896-73703896	skin	malignant_melanoma	Substitution - Missense
c.932C>T; p.T311M; 15:73703857-73703857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.697A>G; p.S233G; 15:73703050-73703050	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.697A>G; p.S233G; 15:73703050-73703050	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.407T>C; p.L136P; 15:73702582-73702582	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487A>T; p.I163F; 15:73702840-73702840	pancreas	carcinoma	Substitution - Missense
c.1151C>T; p.S384F; 15:73704254-73704254	skin	malignant_melanoma	Substitution - Missense
c.576G>A; p.T192T; 15:73702929-73702929	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.133G>A; p.D45N; 15:73702308-73702308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.133G>A; p.D45N; 15:73702308-73702308	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.291G>T; p.P97P; 15:73702466-73702466	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.939C>T; p.L313L; 15:73703864-73703864	skin	malignant_melanoma	Substitution - coding silent
c.992G>A; p.R331H; 15:73703917-73703917	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.380G>A; p.R127Q; 15:73702555-73702555	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1315C>T; p.L439L; 15:73704418-73704418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.308G>A; p.G103D; 15:73702483-73702483	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4C>T; p.L2L; 15:73699643-73699643	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.4C>T; p.L2L; 15:73699643-73699643	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.56G>A; p.G19E; 15:73699695-73699695	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.916G>A; p.A306T; 15:73703841-73703841	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.227T>C; p.V76A; 15:73702402-73702402	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.L212L; 15:73702989-73702989	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.641C>T; p.A214V; 15:73702994-73702994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.F129F; 15:73702562-73702562	skin	malignant_melanoma	Substitution - coding silent
c.479C>T; p.T160M; 15:73702832-73702832	thyroid	other; neoplasm	Substitution - Missense
c.479C>T; p.T160M; 15:73702832-73702832	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.497C>T; p.S166F; 15:73702850-73702850	skin	malignant_melanoma	Substitution - Missense
c.1160G>A; p.R387Q; 15:73704263-73704263	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1075C>T; p.P359S; 15:73704178-73704178	skin	malignant_melanoma	Substitution - Missense
c.1583-9G>A; p.?; 15:73712925-73712925	oesophagus	carcinoma; adenocarcinoma	Unknown
c.735A>G; p.G245G; 15:73703660-73703660	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.471A>C; p.P157P; 15:73702824-73702824	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.369C>T; p.F123F; 15:73702544-73702544	skin	malignant_melanoma	Substitution - coding silent
c.1221C>A; p.N407K; 15:73704324-73704324	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1230G>T; p.T410T; 15:73704333-73704333	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1023C>T; p.F341F; 15:73703948-73703948	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1033C>T; p.R345W; 15:73703958-73703958	skin	malignant_melanoma	Substitution - Missense
c.313G>A; p.A105T; 15:73702488-73702488	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.7C>T; p.R3C; 15:73699646-73699646	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.251A>G; p.D84G; 15:73702426-73702426	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.936C>T; p.A312A; 15:73703861-73703861	skin	malignant_melanoma	Substitution - coding silent
c.198C>G; p.I66M; 15:73702373-73702373	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1045A>T; p.S349C; 15:73703970-73703970	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1409C>T; p.T470I; 15:73708378-73708378	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1350C>T; p.H450H; 15:73704453-73704453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.787G>A; p.D263N; 15:73703712-73703712	breast	carcinoma	Substitution - Missense
c.985C>T; p.R329C; 15:73703910-73703910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1117C>T; p.L373L; 15:73704220-73704220	skin; neck	malignant_melanoma	Substitution - coding silent
c.596A>G; p.Q199R; 15:73702949-73702949	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>T; p.S242I; 15:73703078-73703078	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Missense
c.1121G>A; p.R374Q; 15:73704224-73704224	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.402C>T; p.V134V; 15:73702577-73702577	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.398C>A; p.A133D; 15:73702573-73702573	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.845A>G; p.N282S; 15:73703770-73703770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.467G>C; p.R156P; 15:73702820-73702820	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1376C>A; p.P459H; 15:73708345-73708345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1503A>T; p.A501A; 15:73708472-73708472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.784A>T; p.T262S; 15:73703709-73703709	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.939C>G; p.L313L; 15:73703864-73703864	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.621C>T; p.I207I; 15:73702974-73702974	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1585G>T; p.D529Y; 15:73712936-73712936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>A; p.A90T; 15:73702443-73702443	urinary_tract; bladder	carcinoma	Substitution - Missense
c.800G>A; p.R267H; 15:73703725-73703725	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.800G>A; p.R267H; 15:73703725-73703725	breast	carcinoma	Substitution - Missense
c.1141A>G; p.I381V; 15:73704244-73704244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.274C>T; p.R92C; 15:73702449-73702449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>A; p.S411S; 15:73704336-73704336	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.810C>T; p.F270F; 15:73703735-73703735	skin	malignant_melanoma	Substitution - coding silent
c.142C>A; p.L48M; 15:73702317-73702317	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation