lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	79109
Symbol	MAPKAP1
Synonymous	JC310\|MIP1\|SIN1\|SIN1b\|SIN1g
Full name	mitogen-activated protein kinase associated protein 1
Gene description	MEKK2-interacting protein 1\|SAPK-interacting protein 1\|TORC2 subunit MAPKAP1\|mSIN1\|mitogen-activated protein kinase 2-associated protein 1\|ras inhibitor MGC2745\|stress-activated map kinase interacting protein 1\|stress-activated map kinase-interacting prot
Cytoband	9q33.3
Gene type	protein-coding
Synonymous	MIM:610558; HGNC:HGNC:18752; Ensembl:ENSG00000119487; HPRD:17464; Vega:OTTHUMG00000020683

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.747T>C; p.D249D; 9:125559734-125559734	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.932G>A; p.R311Q; 9:125543085-125543085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1354T>G; p.S452A; 9:125438994-125438994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.944C>T; p.S315F; 9:125543073-125543073	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.726C>T; p.D242D; 9:125559755-125559755	breast	carcinoma	Substitution - coding silent
c.562G>A; p.D188N; 9:125585664-125585664	breast	carcinoma	Substitution - Missense
c.869C>T; p.S290F; 9:125543148-125543148	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1443G>C; p.K481N; 9:125438905-125438905	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.242G>C; p.R81T; 9:125672333-125672333	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.90T>G; p.V30V; 9:125672485-125672485	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1372C>T; p.R458W; 9:125438976-125438976	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.110A>G; p.D37G; 9:125672465-125672465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.958+1delG; p.?; 9:125543058-125543058	pancreas	carcinoma; ductal_carcinoma	Unknown
c.867C>A; p.F289L; 9:125543150-125543150	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1373G>T; p.R458L; 9:125438975-125438975	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1356G>A; p.S452S; 9:125438992-125438992	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1356G>A; p.S452S; 9:125438992-125438992	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.544C>T; p.P182S; 9:125585682-125585682	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.766A>C; p.K256Q; 9:125559715-125559715	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>A; p.V30I; 9:125672487-125672487	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1238G>T; p.S413I; 9:125444598-125444598	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.582C>T; p.T194T; 9:125585644-125585644	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1405C>T; p.L469L; 9:125438943-125438943	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.672-3C>T; p.?; 9:125559812-125559812	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.644C>T; p.T215I; 9:125585582-125585582	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1097T>C; p.L366P; 9:125484445-125484445	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.975G>A; p.G325G; 9:125484567-125484567	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.752A>G; p.N251S; 9:125559729-125559729	liver	carcinoma	Substitution - Missense
c.752A>G; p.N251S; 9:125559729-125559729	liver	carcinoma	Substitution - Missense
c.175G>T; p.G59C; 9:125672400-125672400	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1329G>T; p.V443V; 9:125444507-125444507	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.647G>T; p.S216I; 9:125585579-125585579	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.382_383insA; p.S128fs*28; 9:125657766-125657767	stomach	adenocarcinoma	Insertion - Frameshift
c.381_382insA; p.S128fs*28; 9:125657767-125657768	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.581C>T; p.T194I; 9:125585645-125585645	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1306G>A; p.A436T; 9:125444530-125444530	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.729C>A; p.T243T; 9:125559752-125559752	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1373G>A; p.R458Q; 9:125438975-125438975	ovary	other; neoplasm	Substitution - Missense
c.601G>A; p.A201T; 9:125585625-125585625	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.624G>A; p.G208G; 9:125585602-125585602	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.656G>A; p.R219Q; 9:125585570-125585570	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993G>A; p.S331S; 9:125484549-125484549	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.251C>T; p.S84L; 9:125672324-125672324	skin	malignant_melanoma	Substitution - Missense
c.44G>A; p.R15Q; 9:125672531-125672531	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165G>T; p.Q55H; 9:125672410-125672410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.697C>T; p.H233Y; 9:125559784-125559784	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.663G>T; p.P221P; 9:125585563-125585563	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.91C>G; p.L31V; 9:125672484-125672484	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1393A>G; p.K465E; 9:125438955-125438955	skin	malignant_melanoma	Substitution - Missense
c.503A>G; p.H168R; 9:125585723-125585723	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>A; p.A415E; 9:125444592-125444592	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.657G>A; p.R219R; 9:125585569-125585569	skin	malignant_melanoma	Substitution - coding silent
c.538T>C; p.Y180H; 9:125585688-125585688	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.296A>C; p.N99T; 9:125669871-125669871	liver	carcinoma	Substitution - Missense
c.296A>C; p.N99T; 9:125669871-125669871	liver	carcinoma	Substitution - Missense
c.1035C>G; p.H345Q; 9:125484507-125484507	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1113_1121delCAAAGTAGA; p.D371_V373delDKV; 9:125468088-125468096	thyroid	carcinoma; anaplastic_carcinoma	Deletion - In frame
c.648C>T; p.S216S; 9:125585578-125585578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.845G>A; p.R282Q; 9:125559636-125559636	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.539A>G; p.Y180C; 9:125585687-125585687	breast	carcinoma	Substitution - Missense
c.433C>T; p.R145C; 9:125657716-125657716	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.466C>T; p.P156S; 9:125657683-125657683	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.532G>A; p.D178N; 9:125585694-125585694	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.281G>A; p.R94Q; 9:125669886-125669886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.281G>A; p.R94Q; 9:125669886-125669886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.281G>A; p.R94Q; 9:125669886-125669886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1259C>T; p.T420M; 9:125444577-125444577	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1259C>T; p.T420M; 9:125444577-125444577	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.E220K; 9:125585568-125585568	urinary_tract; bladder	carcinoma	Substitution - Missense
c.971A>G; p.D324G; 9:125484571-125484571	breast	carcinoma	Substitution - Missense
c.1127A>G; p.D376G; 9:125468082-125468082	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1127A>G; p.D376G; 9:125468082-125468082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1127A>G; p.D376G; 9:125468082-125468082	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.381delA; p.K127fs*20; 9:125657768-125657768	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.303C>G; p.I101M; 9:125669864-125669864	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.482C>G; p.S161C; 9:125657667-125657667	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation