Cancer metastasis database

Annotation category 5

Gene information

Gene ID 7518
Symbol

XRCC4

Synonymous

-

Full name

X-ray repair complementing defective repair in Chinese hamster cells 4

Gene description

DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster

Cytoband

5q14.2

Gene type

protein-coding

Synonymous

MIM:194363; HGNC:HGNC:12831; Ensembl:ENSG00000152422; HPRD:15951; Vega:OTTHUMG00000131319

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.182T>C; p.M61T; 5:83111070-83111070

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.138A>G; p.T46T; 5:83105057-83105057

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.535C>T; p.R179W; 5:83203604-83203604

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.588T>A; p.N196K; 5:83203657-83203657

breastcarcinomaSubstitution - Missense

c.894-7G>A; p.?; 5:83353124-83353124

livercarcinoma; hepatocellular_carcinomaUnknown

c.824G>A; p.R275Q; 5:83258608-83258608

breastcarcinomaSubstitution - Missense

c.178G>A; p.A60T; 5:83111066-83111066

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.464G>T; p.W155L; 5:83195918-83195918

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.546G>C; p.L182L; 5:83203615-83203615

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.469delG; p.D157fs*10; 5:83195923-83195923

haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaDeletion - Frameshift

c.93T>G; p.G31G; 5:83105012-83105012

prostatecarcinomaSubstitution - coding silent

c.107T>C; p.L36P; 5:83105026-83105026

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.264T>G; p.F88L; 5:83111152-83111152

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.367A>G; p.I123V; 5:83195821-83195821

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.455T>C; p.L152P; 5:83195909-83195909

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.638+2T>C; p.?; 5:83203709-83203709

endometriumcarcinoma; endometrioid_carcinomaUnknown

c.985G>C; p.D329H; 5:83353222-83353222

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.256T>C; p.F86L; 5:83111144-83111144

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.902C>T; p.S301F; 5:83353139-83353139

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.428A>G; p.H143R; 5:83195882-83195882

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.478G>T; p.G160*; 5:83195932-83195932

skin; handmalignant_melanomaSubstitution - Nonsense

c.225G>A; p.L75L; 5:83111113-83111113

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.902C>A; p.S301Y; 5:83353139-83353139

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.804A>T; p.P268P; 5:83258588-83258588

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.990C>A; p.L330L; 5:83353227-83353227

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.990C>A; p.L330L; 5:83353227-83353227

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.40C>G; p.P14A; 5:83104959-83104959

skinmalignant_melanomaSubstitution - Missense

c.40C>G; p.P14A; 5:83104959-83104959

skinmalignant_melanomaSubstitution - Missense

c.749C>A; p.A250D; 5:83258533-83258533

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.42C>T; p.P14P; 5:83104961-83104961

skinmalignant_melanomaSubstitution - coding silent

c.326G>T; p.G109V; 5:83195780-83195780

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.964C>T; p.L322L; 5:83353201-83353201

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.373G>T; p.E125*; 5:83195827-83195827

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.41C>A; p.P14H; 5:83104960-83104960

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.333C>T; p.F111F; 5:83195787-83195787

breastcarcinomaSubstitution - coding silent

c.556G>T; p.E186*; 5:83203625-83203625

pancreascarcinomaSubstitution - Nonsense

c.541A>T; p.I181F; 5:83203610-83203610

skinmalignant_melanomaSubstitution - Missense

c.541A>T; p.I181F; 5:83203610-83203610

skinmalignant_melanomaSubstitution - Missense

c.541A>T; p.I181F; 5:83203610-83203610

skinmalignant_melanomaSubstitution - Missense

c.20G>T; p.R7I; 5:83104939-83104939

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.867G>T; p.Q289H; 5:83258651-83258651

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.867G>T; p.Q289H; 5:83258651-83258651

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.940G>T; p.A314S; 5:83353177-83353177

livercarcinomaSubstitution - Missense

c.793G>A; p.D265N; 5:83258577-83258577

breastcarcinomaSubstitution - Missense

c.47T>A; p.I16K; 5:83104966-83104966

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.192G>T; p.G64G; 5:83111080-83111080

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.380delT; p.C128fs*25; 5:83195834-83195834

large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.69T>C; p.S23S; 5:83104988-83104988

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.158C>T; p.S53F; 5:83111046-83111046

skinmalignant_melanomaSubstitution - Missense

c.537G>T; p.R179R; 5:83203606-83203606

prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.658G>C; p.E220Q; 5:83204834-83204834

breastcarcinomaSubstitution - Missense

c.836A>G; p.N279S; 5:83258620-83258620

prostatecarcinomaSubstitution - Missense

c.483-1G>T; p.?; 5:83203551-83203551

large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.344A>G; p.K115R; 5:83195798-83195798

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.279T>C; p.C93C; 5:83111167-83111167

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.279T>C; p.C93C; 5:83111167-83111167

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.431T>C; p.L144P; 5:83195885-83195885

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.921T>G; p.S307S; 5:83353158-83353158

livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.288C>A; p.F96L; 5:83111176-83111176

breastcarcinomaSubstitution - Missense

c.430C>T; p.L144L; 5:83195884-83195884

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.688G>A; p.D230N; 5:83204864-83204864

breastcarcinomaSubstitution - Missense

c.926A>G; p.K309R; 5:83353163-83353163

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.727C>T; p.L243F; 5:83204903-83204903

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense