lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7476
Symbol	WNT7A
Synonymous	-
Full name	wingless-type MMTV integration site family, member 7A
Gene description	protein Wnt-7a\|proto-oncogene Wnt7a protein
Cytoband	3p25
Gene type	protein-coding
Synonymous	MIM:601570; HGNC:HGNC:12786; HPRD:03341

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.873C>T; p.G291G; 3:13819121-13819121	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.241C>T; p.R81C; 3:13875004-13875004	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>C; p.A50A; 3:13875095-13875095	skin	malignant_melanoma	Substitution - coding silent
c.1032G>A; p.E344E; 3:13818962-13818962	skin	malignant_melanoma	Substitution - coding silent
c.706G>A; p.V236I; 3:13819288-13819288	breast	carcinoma	Substitution - Missense
c.706G>A; p.V236I; 3:13819288-13819288	breast	carcinoma	Substitution - Missense
c.314C>A; p.A105E; 3:13854788-13854788	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.441G>A; p.W147*; 3:13854661-13854661	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.441G>A; p.W147*; 3:13854661-13854661	NS	malignant_melanoma	Substitution - Nonsense
c.877G>A; p.A293T; 3:13819117-13819117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.M307I; 3:13819073-13819073	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.476G>A; p.G159D; 3:13854626-13854626	skin	malignant_melanoma	Substitution - Missense
c.231C>T; p.F77F; 3:13875014-13875014	skin	malignant_melanoma	Substitution - coding silent
c.921G>T; p.M307I; 3:13819073-13819073	breast	carcinoma	Substitution - Missense
c.51C>A; p.G17G; 3:13879766-13879766	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.315G>A; p.A105A; 3:13854787-13854787	breast	carcinoma	Substitution - coding silent
c.315G>A; p.A105A; 3:13854787-13854787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.315G>A; p.A105A; 3:13854787-13854787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.61C>T; p.L21F; 3:13879756-13879756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.286G>A; p.E96K; 3:13874959-13874959	skin	malignant_melanoma	Substitution - Missense
c.832T>A; p.C278S; 3:13819162-13819162	NS	malignant_melanoma	Substitution - Missense
c.906C>T; p.S302S; 3:13819088-13819088	pancreas	carcinoma	Substitution - coding silent
c.1038C>A; p.Y346*; 3:13818956-13818956	breast	carcinoma	Substitution - Nonsense
c.99C>T; p.G33G; 3:13875146-13875146	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.782G>A; p.R261H; 3:13819212-13819212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.782G>A; p.R261H; 3:13819212-13819212	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.790A>T; p.M264L; 3:13819204-13819204	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>A; p.I41I; 3:13875122-13875122	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.821C>T; p.S274L; 3:13819173-13819173	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.553A>T; p.N185Y; 3:13854549-13854549	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.305G>C; p.R102P; 3:13854797-13854797	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.A118V; 3:13854749-13854749	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>C; p.E199Q; 3:13819399-13819399	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.232C>T; p.R78C; 3:13875013-13875013	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.G303S; 3:13819087-13819087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>A; p.E72K; 3:13875031-13875031	urinary_tract; bladder	carcinoma	Substitution - Missense
c.214G>A; p.E72K; 3:13875031-13875031	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.734G>A; p.R245H; 3:13819260-13819260	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.576G>A; p.L192L; 3:13819418-13819418	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.911G>C; p.C304S; 3:13819083-13819083	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.889A>C; p.T297P; 3:13819105-13819105	skin	malignant_melanoma	Substitution - Missense
c.324C>T; p.Y108Y; 3:13854778-13854778	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.629C>G; p.T210S; 3:13819365-13819365	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.707T>C; p.V236A; 3:13819287-13819287	skin	malignant_melanoma	Substitution - Missense
c.202A>C; p.M68L; 3:13875043-13875043	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.S129S; 3:13854715-13854715	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.502G>T; p.D168Y; 3:13854600-13854600	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.922T>A; p.C308S; 3:13819072-13819072	breast	carcinoma	Substitution - Missense
c.137C>T; p.P46L; 3:13875108-13875108	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.699C>T; p.N233N; 3:13819295-13819295	skin	malignant_melanoma	Substitution - coding silent
c.977G>T; p.C326F; 3:13819017-13819017	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.204G>T; p.M68I; 3:13875041-13875041	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.955G>T; p.A319S; 3:13819039-13819039	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1013C>T; p.T338M; 3:13818981-13818981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1013C>T; p.T338M; 3:13818981-13818981	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.N185N; 3:13854547-13854547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.352G>A; p.A118T; 3:13854750-13854750	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529_530CG>AT; p.R177M; 3:13854572-13854573	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.N185N; 3:13854547-13854547	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.304C>T; p.R102W; 3:13854798-13854798	skin	malignant_melanoma	Substitution - Missense
c.304C>T; p.R102W; 3:13854798-13854798	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1041G>A; p.T347T; 3:13818953-13818953	pancreas	carcinoma	Substitution - coding silent
c.788C>T; p.P263L; 3:13819206-13819206	skin	malignant_melanoma	Substitution - Missense
c.155G>C; p.C52S; 3:13875090-13875090	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1025G>A; p.R342H; 3:13818969-13818969	liver	carcinoma	Substitution - Missense
c.526G>T; p.A176S; 3:13854576-13854576	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.100G>A; p.A34T; 3:13875145-13875145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.Y158Y; 3:13854628-13854628	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.459T>C; p.S153S; 3:13854643-13854643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.459T>C; p.S153S; 3:13854643-13854643	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.171C>T; p.D57D; 3:13875074-13875074	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.667G>T; p.E223*; 3:13819327-13819327	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.724C>T; p.R242C; 3:13819270-13819270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.492G>T; p.K164N; 3:13854610-13854610	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.226C>T; p.Q76*; 3:13875019-13875019	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.600T>G; p.C200W; 3:13819394-13819394	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984C>T; p.F328F; 3:13819010-13819010	breast	carcinoma	Substitution - coding silent
c.984C>T; p.F328F; 3:13819010-13819010	skin	malignant_melanoma	Substitution - coding silent
c.299-4G>A; p.?; 3:13854807-13854807	pancreas	carcinoma	Unknown
c.612C>T; p.G204G; 3:13819382-13819382	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.57C>G; p.V19V; 3:13879760-13879760	breast	carcinoma	Substitution - coding silent
c.495C>T; p.V165V; 3:13854607-13854607	breast	carcinoma	Substitution - coding silent
c.150G>A; p.A50A; 3:13875095-13875095	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.381C>T; p.N127N; 3:13854721-13854721	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.822G>A; p.S274S; 3:13819172-13819172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.822G>A; p.S274S; 3:13819172-13819172	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.535C>G; p.L179V; 3:13854567-13854567	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.623C>T; p.S208L; 3:13819371-13819371	skin	malignant_melanoma	Substitution - Missense
c.36C>G; p.L12L; 3:13879781-13879781	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.547C>T; p.H183Y; 3:13854555-13854555	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.679G>A; p.V227M; 3:13819315-13819315	central_nervous_system; brain	glioma	Substitution - Missense
c.388G>A; p.D130N; 3:13854714-13854714	breast	carcinoma	Substitution - Missense
c.268C>T; p.R90C; 3:13874977-13874977	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.745C>T; p.P249S; 3:13819249-13819249	parathyroid	adenoma	Substitution - Missense
c.277T>C; p.F93L; 3:13874968-13874968	skin	malignant_melanoma	Substitution - Missense
c.639G>A; p.T213T; 3:13819355-13819355	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.169G>A; p.D57N; 3:13875076-13875076	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.989G>A; p.W330*; 3:13819005-13819005	skin	malignant_melanoma	Substitution - Nonsense
c.1046_1047insA; p.*350fs?; 3:13818947-13818948	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.513G>T; p.E171D; 3:13854589-13854589	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.274G>A; p.V92I; 3:13874971-13874971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.365C>G; p.A122G; 3:13854737-13854737	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>T; p.E171*; 3:13854591-13854591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.314C>T; p.A105V; 3:13854788-13854788	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.W147*; 3:13854662-13854662	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.273C>G; p.T91T; 3:13874972-13874972	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.246G>A; p.W82*; 3:13874999-13874999	skin	malignant_melanoma	Substitution - Nonsense
c.246G>A; p.W82*; 3:13874999-13874999	skin	malignant_melanoma	Substitution - Nonsense
c.269G>T; p.R90L; 3:13874976-13874976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.A163T; 3:13854615-13854615	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1024C>T; p.R342C; 3:13818970-13818970	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1024C>T; p.R342C; 3:13818970-13818970	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.487G>A; p.A163T; 3:13854615-13854615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.565C>T; p.R189*; 3:13854537-13854537	skin	malignant_melanoma	Substitution - Nonsense
c.516C>G; p.I172M; 3:13854586-13854586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.687G>A; p.K229K; 3:13819307-13819307	skin	malignant_melanoma	Substitution - coding silent
c.463G>A; p.D155N; 3:13854639-13854639	skin	malignant_melanoma	Substitution - Missense
c.180C>T; p.I60I; 3:13875065-13875065	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.463G>A; p.D155N; 3:13854639-13854639	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469C>T; p.R157C; 3:13854633-13854633	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.853G>A; p.G285S; 3:13819141-13819141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>T; p.G114C; 3:13854762-13854762	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.868C>A; p.Q290K; 3:13819126-13819126	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.934G>A; p.G312S; 3:13819060-13819060	skin	malignant_melanoma	Substitution - Missense
c.934G>A; p.G312S; 3:13819060-13819060	skin	malignant_melanoma	Substitution - Missense
c.282delG; p.K95fs*34; 3:13874963-13874963	breast	carcinoma	Deletion - Frameshift
c.117C>A; p.N39K; 3:13875128-13875128	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.208C>T; p.L70L; 3:13875037-13875037	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.700G>A; p.E234K; 3:13819294-13819294	breast	carcinoma	Substitution - Missense
c.944C>T; p.T315I; 3:13819050-13819050	skin	malignant_melanoma	Substitution - Missense
c.280G>A; p.G94R; 3:13874965-13874965	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation