Cancer metastasis database

Annotation category 5

Gene information

Gene ID 7372
Symbol

UMPS

Synonymous

OPRT

Full name

uridine monophosphate synthetase

Gene description

OMPdecase|OPRTase|UMP synthase|orotate phosphoribosyltransferase|orotidine 5'-phosphate decarboxylase|uridine 5'-monophosphate synthase

Cytoband

3q13

Gene type

protein-coding

Synonymous

MIM:613891; HGNC:HGNC:12563; Ensembl:ENSG00000114491; HPRD:02022; Vega:OTTHUMG00000159431

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.13C>G; p.R5G; 3:124730484-124730484

 breastcarcinomaSubstitution - Missense

c.941A>C; p.K314T; 3:124738198-124738198

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.675C>G; p.L225L; 3:124737932-124737932

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.137G>A; p.R46Q; 3:124730608-124730608

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1222A>T; p.M408L; 3:124742215-124742215

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.700C>G; p.P234A; 3:124737957-124737957

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1285G>A; p.G429S; 3:124743926-124743926

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.213G>T; p.V71V; 3:124735149-124735149

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1040G>T; p.G347V; 3:124740081-124740081

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1352G>A; p.R451H; 3:124743993-124743993

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.760C>T; p.L254L; 3:124738017-124738017

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1098C>T; p.L366L; 3:124740139-124740139

 soft_tissue; blood_vesselangiosarcomaSubstitution - coding silent

c.550G>A; p.E184K; 3:124737807-124737807

 livercarcinomaSubstitution - Missense

c.550G>A; p.E184K; 3:124737807-124737807

 livercarcinomaSubstitution - Missense

c.372_374delTGT; p.V126delV; 3:124737629-124737631

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.372_374delTGT; p.V126delV; 3:124737629-124737631

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.14G>T; p.R5L; 3:124730485-124730485

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1171G>A; p.E391K; 3:124742164-124742164

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.206A>T; p.D69V; 3:124735142-124735142

 skinmalignant_melanomaSubstitution - Missense

c.547C>T; p.L183F; 3:124737804-124737804

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.644C>T; p.P215L; 3:124737901-124737901

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1066G>T; p.E356*; 3:124740107-124740107

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.843G>C; p.K281N; 3:124738100-124738100

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1066G>T; p.E356*; 3:124740107-124740107

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.295G>C; p.E99Q; 3:124735231-124735231

 oesophaguscarcinomaSubstitution - Missense

c.953T>A; p.I318K; 3:124738210-124738210

 kidneyother; neoplasmSubstitution - Missense

c.713C>T; p.P238L; 3:124737970-124737970

 skinmalignant_melanomaSubstitution - Missense

c.505C>T; p.R169C; 3:124737762-124737762

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.638G>C; p.G213A; 3:124737895-124737895

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1351C>T; p.R451C; 3:124743992-124743992

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.159T>C; p.V53V; 3:124735095-124735095

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1351C>T; p.R451C; 3:124743992-124743992

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.894G>C; p.L298F; 3:124738151-124738151

 breastcarcinomaSubstitution - Missense

c.811G>C; p.D271H; 3:124738068-124738068

 breastcarcinomaSubstitution - Missense

c.1375C>T; p.R459C; 3:124744016-124744016

 skin; legmalignant_melanoma; superficial_spreadingSubstitution - Missense

c.1180T>A; p.S394T; 3:124742173-124742173

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.670G>T; p.E224*; 3:124737927-124737927

 oesophaguscarcinoma; adenocarcinomaSubstitution - Nonsense

c.1337T>G; p.I446S; 3:124743978-124743978

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.615C>A; p.V205V; 3:124737872-124737872

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.195C>T; p.G65G; 3:124735131-124735131

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.708C>T; p.I236I; 3:124737965-124737965

 skinmalignant_melanomaSubstitution - coding silent

c.1320C>T; p.G440G; 3:124743961-124743961

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1320C>T; p.G440G; 3:124743961-124743961

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.937C>T; p.R313W; 3:124738194-124738194

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.913C>T; p.H305Y; 3:124738170-124738170

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - Missense

c.913C>T; p.H305Y; 3:124738170-124738170

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - Missense

c.528G>A; p.L176L; 3:124737785-124737785

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1282C>A; p.L428I; 3:124743923-124743923

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.137G>T; p.R46L; 3:124730608-124730608

 central_nervous_system; braingliomaSubstitution - Missense

c.7G>T; p.V3F; 3:124730478-124730478

 skin; legmalignant_melanomaSubstitution - Missense

c.1325G>A; p.R442Q; 3:124743966-124743966

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.369A>G; p.E123E; 3:124737626-124737626

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1209C>T; p.G403G; 3:124742202-124742202

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.377T>C; p.V126A; 3:124737634-124737634

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1308A>C; p.Q436H; 3:124743949-124743949

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.29C>T; p.P10L; 3:124730500-124730500

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.94C>G; p.L32V; 3:124730565-124730565

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.70G>T; p.G24W; 3:124730541-124730541

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1332C>T; p.S444S; 3:124743973-124743973

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.100T>C; p.S34P; 3:124730571-124730571

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1242C>T; p.H414H; 3:124742235-124742235

 oesophaguscarcinomaSubstitution - coding silent

c.831C>T; p.I277I; 3:124738088-124738088

 thyroidother; neoplasmSubstitution - coding silent

c.702C>T; p.P234P; 3:124737959-124737959

 bone; pelvischondrosarcomaSubstitution - coding silent

c.888G>T; p.K296N; 3:124738145-124738145

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.931G>A; p.E311K; 3:124738188-124738188

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.681C>T; p.F227F; 3:124737938-124737938

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.681C>T; p.F227F; 3:124737938-124737938

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.681C>T; p.F227F; 3:124737938-124737938

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.1372G>C; p.D458H; 3:124744013-124744013

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.8_9delTC; p.V3fs*66; 3:124730479-124730480

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.1223T>G; p.M408R; 3:124742216-124742216

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.78C>T; p.F26F; 3:124730549-124730549

 breastcarcinomaSubstitution - coding silent

c.645C>T; p.P215P; 3:124737902-124737902

 skinmalignant_melanomaSubstitution - coding silent

c.169T>G; p.L57V; 3:124735105-124735105

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.405T>G; p.T135T; 3:124737662-124737662

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1376G>A; p.R459H; 3:124744017-124744017

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1087C>T; p.R363W; 3:124740128-124740128

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1087C>T; p.R363W; 3:124740128-124740128

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense