lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7296
Symbol	TXNRD1
Synonymous	GRIM-12\|TR\|TR1\|TRXR1\|TXNR
Full name	thioredoxin reductase 1
Gene description	KM-102-derived reductase-like factor\|gene associated with retinoic and IFN-induced mortality 12 protein\|gene associated with retinoic and interferon-induced mortality 12 protein\|oxidoreductase\|thioredoxin reductase 1, cytoplasmic\|thioredoxin reductase GRI
Cytoband	12q23-q24.1
Gene type	protein-coding
Synonymous	MIM:601112; HGNC:HGNC:12437; Ensembl:ENSG00000198431; HPRD:03068; Vega:OTTHUMG00000166481

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1189G>T; p.E397*; 12:104331630-104331630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.479C>T; p.A160V; 12:104319525-104319525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.543T>C; p.D181D; 12:104321094-104321094	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.543T>C; p.D181D; 12:104321094-104321094	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.207G>A; p.L69L; 12:104315823-104315823	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.165C>T; p.L55L; 12:104315781-104315781	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.814C>T; p.Q272*; 12:104325385-104325385	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.814C>T; p.Q272*; 12:104325385-104325385	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1492T>C; p.*498R; 12:104348413-104348413	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.858+5G>C; p.?; 12:104325434-104325434	liver	carcinoma	Unknown
c.146T>G; p.L49R; 12:104313303-104313303	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.468A>T; p.R156S; 12:104319514-104319514	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.964G>A; p.E322K; 12:104327543-104327543	skin; extremity	malignant_melanoma	Substitution - Missense
c.136C>T; p.P46S; 12:104313293-104313293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>T; p.V256F; 12:104325337-104325337	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.43C>T; p.L15F; 12:104311368-104311368	skin	malignant_melanoma	Substitution - Missense
c.1092G>T; p.K364N; 12:104327671-104327671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.506G>A; p.G169D; 12:104319552-104319552	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1472G>A; p.S491N; 12:104348393-104348393	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.645C>T; p.D215D; 12:104321196-104321196	breast	carcinoma	Substitution - coding silent
c.511C>G; p.P171A; 12:104319557-104319557	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.645C>T; p.D215D; 12:104321196-104321196	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.562T>C; p.Y188H; 12:104321113-104321113	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.754G>A; p.V252I; 12:104321305-104321305	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.830A>T; p.E277V; 12:104325401-104325401	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.227T>C; p.L76S; 12:104315843-104315843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>A; p.E238K; 12:104321263-104321263	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.712G>A; p.E238K; 12:104321263-104321263	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1_2insT; p.?; 12:104311326-104311327	large_intestine	carcinoma; adenocarcinoma	Unknown
c.137C>T; p.P46L; 12:104313294-104313294	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1112C>A; p.P371Q; 12:104331553-104331553	liver	carcinoma	Substitution - Missense
c.772C>G; p.Q258E; 12:104325343-104325343	skin	malignant_melanoma	Substitution - Missense
c.1490G>A; p.C497Y; 12:104348411-104348411	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.497G>A; p.R166H; 12:104319543-104319543	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.907_908insA; p.T304fs*8; 12:104326395-104326396	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.704A>T; p.K235I; 12:104321255-104321255	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.494C>T; p.P165L; 12:104319540-104319540	skin	malignant_melanoma	Substitution - Missense
c.431A>C; p.N144T; 12:104319477-104319477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.271G>A; p.E91K; 12:104315887-104315887	ovary	other; neoplasm	Substitution - Missense
c.271G>A; p.E91K; 12:104315887-104315887	ovary	other; neoplasm	Substitution - Missense
c.1432G>T; p.V478L; 12:104348353-104348353	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.862A>G; p.M288V; 12:104326350-104326350	breast	carcinoma	Substitution - Missense
c.338A>T; p.N113I; 12:104318970-104318970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1059G>A; p.L353L; 12:104327638-104327638	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.32A>G; p.Y11C; 12:104311357-104311357	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1431+2T>C; p.?; 12:104339275-104339275	stomach	carcinoma; adenocarcinoma	Unknown
c.1431+2T>C; p.?; 12:104339275-104339275	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.913G>A; p.V305I; 12:104326401-104326401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.251G>A; p.R84Q; 12:104315867-104315867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.251G>A; p.R84Q; 12:104315867-104315867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.450A>C; p.K150N; 12:104319496-104319496	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.350G>A; p.R117Q; 12:104318982-104318982	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298A>G; p.R100G; 12:104318930-104318930	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.125A>G; p.D42G; 12:104313282-104313282	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.449A>C; p.K150T; 12:104319495-104319495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.64T>C; p.S22P; 12:104311389-104311389	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>T; p.P171S; 12:104319557-104319557	breast	carcinoma	Substitution - Missense
c.1159G>C; p.E387Q; 12:104331600-104331600	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1159G>C; p.E387Q; 12:104331600-104331600	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.445G>T; p.E149*; 12:104319491-104319491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.523G>T; p.E175*; 12:104319569-104319569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.554C>T; p.S185F; 12:104321105-104321105	skin	malignant_melanoma	Substitution - Missense
c.949C>G; p.P317A; 12:104327528-104327528	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1159G>A; p.E387K; 12:104331600-104331600	urinary_tract; bladder	carcinoma	Substitution - Missense
c.423+1G>A; p.?; 12:104319056-104319056	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1236G>T; p.T412T; 12:104334272-104334272	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1236G>T; p.T412T; 12:104334272-104334272	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.980C>T; p.P327L; 12:104327559-104327559	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.362G>A; p.R121Q; 12:104318994-104318994	skin	malignant_melanoma	Substitution - Missense
c.1089C>G; p.V363V; 12:104327668-104327668	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.707T>C; p.I236T; 12:104321258-104321258	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.695T>G; p.M232R; 12:104321246-104321246	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1477C>T; p.L493F; 12:104348398-104348398	skin	malignant_melanoma	Substitution - Missense
c.698C>T; p.A233V; 12:104321249-104321249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation