Cancer metastasis database

Annotation category 5

Gene information

Gene ID 7186
Symbol

TRAF2

Synonymous

MGC:45012|TRAP|TRAP3

Full name

TNF receptor-associated factor 2

Gene description

E3 ubiquitin-protein ligase TRAF2|tumor necrosis factor type 2 receptor associated protein 3|tumor necrosis factor type 2 receptor-associated protein 3

Cytoband

9q34

Gene type

protein-coding

Synonymous

MIM:601895; HGNC:HGNC:12032; Ensembl:ENSG00000127191; HPRD:03538; Vega:OTTHUMG00000020952

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.25C>T; p.P9S; 9:136898765-136898765

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1362C>T; p.S454S; 9:136925757-136925757

 skinmalignant_melanomaSubstitution - coding silent

c.1288-2A>C; p.?; 9:136925681-136925681

 stomachcarcinoma; adenocarcinomaUnknown

c.341G>A; p.W114*; 9:136900495-136900495

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaSubstitution - Nonsense

c.125G>A; p.R42H; 9:136898865-136898865

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; mantle_cell_lymphomaSubstitution - Missense

c.125G>A; p.R42H; 9:136898865-136898865

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.414G>T; p.A138A; 9:136908117-136908117

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.537C>T; p.H179H; 9:136909928-136909928

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.358G>T; p.E120*; 9:136900512-136900512

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1203C>T; p.T401T; 9:136923916-136923916

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.629G>C; p.G210A; 9:136916566-136916566

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1326C>T; p.H442H; 9:136925721-136925721

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.600G>T; p.E200D; 9:136909991-136909991

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1251G>A; p.P417P; 9:136923964-136923964

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1223C>T; p.S408F; 9:136923936-136923936

 skinmalignant_melanomaSubstitution - Missense

c.270C>G; p.A90A; 9:136900424-136900424

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.363C>G; p.Y121*; 9:136900517-136900517

 thyroidother; neoplasmSubstitution - Nonsense

c.309G>A; p.L103L; 9:136900463-136900463

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1219C>A; p.L407M; 9:136923932-136923932

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.457G>C; p.E153Q; 9:136908160-136908160

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1376C>T; p.P459L; 9:136925771-136925771

 skinmalignant_melanomaSubstitution - Missense

c.1154G>C; p.R385T; 9:136923867-136923867

 breastcarcinoma; lobular_carcinomaSubstitution - Missense

c.1051G>A; p.D351N; 9:136921128-136921128

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.388C>T; p.P130S; 9:136908091-136908091

 skinmalignant_melanomaSubstitution - Missense

c.1015G>C; p.E339Q; 9:136921092-136921092

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.749C>T; p.S250L; 9:136920304-136920304

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1396G>A; p.A466T; 9:136925791-136925791

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1158C>T; p.Y386Y; 9:136923871-136923871

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.340T>C; p.W114R; 9:136900494-136900494

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.128G>T; p.R43M; 9:136898868-136898868

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1134C>T; p.S378S; 9:136921211-136921211

 skinmalignant_melanomaSubstitution - coding silent

c.803T>C; p.L268P; 9:136920358-136920358

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.803T>C; p.L268P; 9:136920358-136920358

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.803T>C; p.L268P; 9:136920358-136920358

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1370_1371delAG; p.R458fs*>44; 9:136925765-136925766

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.1284G>A; p.Q428Q; 9:136923997-136923997

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.129G>T; p.R43S; 9:136898869-136898869

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1120C>T; p.P374S; 9:136921197-136921197

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.493C>T; p.H165Y; 9:136908196-136908196

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.960G>T; p.K320N; 9:136920515-136920515

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1269G>A; p.R423R; 9:136923982-136923982

 skinmalignant_melanomaSubstitution - coding silent

c.1269G>A; p.R423R; 9:136923982-136923982

 skinmalignant_melanomaSubstitution - coding silent

c.861C>T; p.C287C; 9:136920416-136920416

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.790G>A; p.A264T; 9:136920345-136920345

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1123G>A; p.A375T; 9:136921200-136921200

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.448C>T; p.R150C; 9:136908151-136908151

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.266C>T; p.S89L; 9:136899671-136899671

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1370A>T; p.Q457L; 9:136925765-136925765

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.1370A>T; p.Q457L; 9:136925765-136925765

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.1370A>T; p.Q457L; 9:136925765-136925765

 breastcarcinoma; HER-positive_carcinomaSubstitution - Missense

c.821G>T; p.S274I; 9:136920376-136920376

 thyroidother; neoplasmSubstitution - Missense

c.914G>T; p.R305L; 9:136920469-136920469

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1401C>T; p.S467S; 9:136925796-136925796

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.313G>A; p.A105T; 9:136900467-136900467

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.490C>T; p.R164W; 9:136908193-136908193

 breastcarcinomaSubstitution - Missense

c.1115G>A; p.R372H; 9:136921192-136921192

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1257C>T; p.D419D; 9:136923970-136923970

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.538G>A; p.E180K; 9:136909929-136909929

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.789C>T; p.H263H; 9:136920344-136920344

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1268G>A; p.R423Q; 9:136923981-136923981

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1230C>T; p.F410F; 9:136923943-136923943

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1002G>A; p.A334A; 9:136921079-136921079

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.802C>T; p.L268F; 9:136920357-136920357

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1250C>T; p.P417L; 9:136923963-136923963

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1197C>T; p.D399D; 9:136923910-136923910

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.223G>A; p.E75K; 9:136899628-136899628

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.223G>A; p.E75K; 9:136899628-136899628

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.223G>A; p.E75K; 9:136899628-136899628

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1159G>A; p.G387S; 9:136923872-136923872

 large_intestine; coloncarcinomaSubstitution - Missense

c.315C>T; p.A105A; 9:136900469-136900469

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1009G>T; p.D337Y; 9:136921086-136921086

 pancreascarcinomaSubstitution - Missense

c.20delC; p.P9fs*77; 9:136898760-136898760

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.20delC; p.P9fs*77; 9:136898760-136898760

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.20delC; p.P9fs*77; 9:136898760-136898760

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.127A>T; p.R43W; 9:136898867-136898867

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.757G>C; p.E253Q; 9:136920312-136920312

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.757G>C; p.E253Q; 9:136920312-136920312

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1348G>A; p.D450N; 9:136925743-136925743

 eye; uveal_tractmalignant_melanoma; spindleSubstitution - Missense

c.106G>A; p.A36T; 9:136898846-136898846

 pancreascarcinomaSubstitution - Missense

c.449G>A; p.R150H; 9:136908152-136908152

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1118T>C; p.I373T; 9:136921195-136921195

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.1462G>A; p.D488N; 9:136925857-136925857

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1491C>T; p.D497D; 9:136925886-136925886

 pancreascarcinomaSubstitution - coding silent

c.1491C>T; p.D497D; 9:136925886-136925886

 pancreascarcinomaSubstitution - coding silent

c.767C>T; p.P256L; 9:136920322-136920322

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense