lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7184
Symbol	HSP90B1
Synonymous	ECGP\|GP96\|GRP94\|HEL-S-125m\|HEL35\|TRA1
Full name	heat shock protein 90kDa beta (Grp94), member 1
Gene description	94 kDa glucose-regulated protein\|endoplasmin\|endothelial cell (HBMEC) glycoprotein\|epididymis luminal protein 35\|epididymis secretory sperm binding protein Li 125m\|heat shock protein 90 kDa beta member 1\|stress-inducible tumor rejection antigen gp96\|tumor
Cytoband	12q24.2-q24.3
Gene type	protein-coding
Synonymous	MIM:191175; HGNC:HGNC:12028; Ensembl:ENSG00000166598; HPRD:01860; Vega:OTTHUMG00000170118

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.831T>G; p.F277L; 12:103937782-103937782	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2258C>G; p.A753G; 12:103946937-103946937	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1219G>A; p.D407N; 12:103941536-103941536	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1404G>A; p.T468T; 12:103942556-103942556	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.743+1G>A; p.?; 12:103934288-103934288	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1745A>G; p.E582G; 12:103943174-103943174	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.228T>C; p.F76F; 12:103932352-103932352	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1517T>C; p.L506P; 12:103942669-103942669	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2096G>A; p.R699Q; 12:103946686-103946686	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.670G>A; p.E224K; 12:103934214-103934214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1568G>A; p.S523N; 12:103942720-103942720	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2037G>A; p.A679A; 12:103946627-103946627	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2170C>T; p.R724W; 12:103946849-103946849	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1240C>T; p.R414C; 12:103941638-103941638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1742C>T; p.P581L; 12:103943171-103943171	skin	malignant_melanoma	Substitution - Missense
c.1240C>T; p.R414C; 12:103941638-103941638	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2170C>T; p.R724W; 12:103946849-103946849	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2170C>T; p.R724W; 12:103946849-103946849	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1261G>A; p.D421N; 12:103941659-103941659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1261G>A; p.D421N; 12:103941659-103941659	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1802G>A; p.S601N; 12:103943231-103943231	skin; shoulder	malignant_melanoma	Substitution - Missense
c.825A>G; p.I275M; 12:103937776-103937776	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.737delC; p.T246fs*6; 12:103934281-103934281	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1891-1G>C; p.?; 12:103943737-103943737	breast	carcinoma	Unknown
c.1814A>C; p.K605T; 12:103943243-103943243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2369A>C; p.E790A; 12:103947417-103947417	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2396A>C; p.E799A; 12:103947646-103947646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1650A>T; p.E550D; 12:103943079-103943079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1682_1683insC; p.K561fs*4; 12:103943111-103943112	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.762A>T; p.E254D; 12:103937713-103937713	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>G; p.S106*; 12:103932848-103932848	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.820T>C; p.F274L; 12:103937771-103937771	skin	malignant_melanoma	Substitution - Missense
c.467G>A; p.R156K; 12:103934011-103934011	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.699T>C; p.I233I; 12:103934243-103934243	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.849C>A; p.S283R; 12:103937800-103937800	prostate	carcinoma	Substitution - Missense
c.195A>G; p.Q65Q; 12:103932319-103932319	skin	malignant_melanoma	Substitution - coding silent
c.2371G>A; p.E791K; 12:103947419-103947419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.901G>A; p.E301K; 12:103938385-103938385	skin	malignant_melanoma	Substitution - Missense
c.599A>T; p.Y200F; 12:103934143-103934143	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.973A>C; p.K325Q; 12:103938457-103938457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2028-11_2032del16; p.?; 12:103946607-103946622	liver	carcinoma	Unknown
c.84T>G; p.D28E; 12:103931555-103931555	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1503G>A; p.S501S; 12:103942655-103942655	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1503G>A; p.S501S; 12:103942655-103942655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1508G>A; p.R503Q; 12:103942660-103942660	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.475T>C; p.L159L; 12:103934019-103934019	skin	malignant_melanoma	Substitution - coding silent
c.184A>C; p.N62H; 12:103932308-103932308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1606G>A; p.D536N; 12:103942758-103942758	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.722T>C; p.L241P; 12:103934266-103934266	liver	carcinoma	Substitution - Missense
c.722T>C; p.L241P; 12:103934266-103934266	liver	carcinoma	Substitution - Missense
c.1686C>T; p.G562G; 12:103943115-103943115	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2032T>G; p.Y678D; 12:103946622-103946622	liver	carcinoma	Substitution - Missense
c.450C>A; p.T150T; 12:103933994-103933994	prostate	adenoma	Substitution - coding silent
c.1271A>T; p.D424V; 12:103941669-103941669	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2341G>T; p.E781*; 12:103947389-103947389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2332G>A; p.E778K; 12:103947380-103947380	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2332G>A; p.E778K; 12:103947380-103947380	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2332G>A; p.E778K; 12:103947380-103947380	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1071T>C; p.A357A; 12:103939604-103939604	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2341G>C; p.E781Q; 12:103947389-103947389	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.22G>T; p.G8C; 12:103930537-103930537	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.292G>C; p.E98Q; 12:103932416-103932416	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2370A>C; p.E790D; 12:103947418-103947418	liver	carcinoma	Substitution - Missense
c.2115A>C; p.E705D; 12:103946794-103946794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2370A>C; p.E790D; 12:103947418-103947418	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1578G>A; p.Q526Q; 12:103942730-103942730	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.160G>A; p.E54K; 12:103932284-103932284	skin	malignant_melanoma	Substitution - Missense
c.710G>A; p.R237K; 12:103934254-103934254	liver	carcinoma	Substitution - Missense
c.795A>G; p.K265K; 12:103937746-103937746	liver	carcinoma	Substitution - coding silent
c.537T>C; p.T179T; 12:103934081-103934081	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1914G>A; p.Q638Q; 12:103943761-103943761	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.495C>T; p.T165T; 12:103934039-103934039	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1744G>A; p.E582K; 12:103943173-103943173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2300_2311del12; p.T771_T774delTEDT; 12:103947348-103947359	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - In frame
c.390G>A; p.E130E; 12:103932921-103932921	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2246T>C; p.I749T; 12:103946925-103946925	soft_tissue; fat	liposarcoma; myxoid-round_cell	Substitution - Missense
c.3G>A; p.M1I; 12:103930518-103930518	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.339T>A; p.D113E; 12:103932870-103932870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1220_1224delATTAC; p.Y408fs*1; 12:103941537-103941541	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.367G>A; p.E123K; 12:103932898-103932898	urinary_tract; bladder	carcinoma	Substitution - Missense
c.174G>T; p.L58F; 12:103932298-103932298	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1794C>T; p.F598F; 12:103943223-103943223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2318A>G; p.D773G; 12:103947366-103947366	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2277C>T; p.P759P; 12:103947325-103947325	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.57C>T; p.V19V; 12:103931528-103931528	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1657C>T; p.P553S; 12:103943086-103943086	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275C>T; p.S92L; 12:103932399-103932399	breast	carcinoma	Substitution - Missense
c.1459G>T; p.E487*; 12:103942611-103942611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1459G>T; p.E487*; 12:103942611-103942611	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1688A>T; p.Y563F; 12:103943117-103943117	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1617C>A; p.Y539*; 12:103942769-103942769	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1175C>A; p.S392Y; 12:103941492-103941492	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1682A>G; p.K561R; 12:103943111-103943111	thyroid	carcinoma	Substitution - Missense
c.2365G>A; p.E789K; 12:103947413-103947413	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2363A>G; p.E788G; 12:103947411-103947411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>T; p.R345I; 12:103939567-103939567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1429G>T; p.D477Y; 12:103942581-103942581	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1103A>G; p.D368G; 12:103941420-103941420	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.550G>C; p.D184H; 12:103934094-103934094	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1422G>A; p.K474K; 12:103942574-103942574	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1507C>T; p.R503*; 12:103942659-103942659	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1722A>G; p.E574E; 12:103943151-103943151	liver	carcinoma	Substitution - coding silent
c.604G>A; p.A202T; 12:103934148-103934148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>T; p.E287*; 12:103938343-103938343	breast	carcinoma	Substitution - Nonsense
c.307G>T; p.E103*; 12:103932838-103932838	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.307G>T; p.E103*; 12:103932838-103932838	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.307G>T; p.E103*; 12:103932838-103932838	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.22G>C; p.G8R; 12:103930537-103930537	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1344C>T; p.R448R; 12:103941867-103941867	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2293G>A; p.E765K; 12:103947341-103947341	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.30C>T; p.C10C; 12:103930545-103930545	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.30C>T; p.C10C; 12:103930545-103930545	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2359_2361delGAT; p.D787delD; 12:103947407-103947409	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.1000G>A; p.E334K; 12:103939533-103939533	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1637G>C; p.R546T; 12:103942789-103942789	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2201C>T; p.A734V; 12:103946880-103946880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1898A>G; p.K633R; 12:103943745-103943745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.822C>G; p.F274L; 12:103937773-103937773	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2380A>C; p.K794Q; 12:103947428-103947428	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.833C>T; p.P278L; 12:103937784-103937784	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2411A>C; p.*804S; 12:103947661-103947661	large_intestine	carcinoma; adenocarcinoma	Nonstop extension
c.2002C>T; p.Q668*; 12:103943849-103943849	skin	malignant_melanoma	Substitution - Nonsense
c.805delA; p.K270fs*6; 12:103937756-103937756	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2383-1G>A; p.?; 12:103947632-103947632	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation