lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7104
Symbol	TM4SF4
Synonymous	ILTMP\|il-TMP
Full name	transmembrane 4 L six family member 4
Gene description	intestinal and liver (il) tetraspan membrane protein\|intestine and liver tetraspan membrane protein\|transmembrane 4 L6 family member 4\|transmembrane 4 superfamily member 4
Cytoband	3q25
Gene type	protein-coding
Synonymous	MIM:606567; HGNC:HGNC:11856; HPRD:07585

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.175-1G>T; p.?; 3:149475822-149475822	lung; middle_lobe	carcinoma; adenocarcinoma	Unknown
c.279G>A; p.T93T; 3:149487633-149487633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.279G>A; p.T93T; 3:149487633-149487633	skin	malignant_melanoma	Substitution - coding silent
c.604G>A; p.V202I; 3:149502688-149502688	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.419A>G; p.E140G; 3:149498739-149498739	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.563G>T; p.G188V; 3:149498883-149498883	thyroid	other; neoplasm	Substitution - Missense
c.227G>T; p.G76V; 3:149475875-149475875	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.583_584delTG; p.C195fs*>8; 3:149498903-149498904	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.440G>A; p.R147Q; 3:149498760-149498760	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.440G>A; p.R147Q; 3:149498760-149498760	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.512T>A; p.M171K; 3:149498832-149498832	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.564G>A; p.G188G; 3:149498884-149498884	skin	malignant_melanoma	Substitution - coding silent
c.564G>A; p.G188G; 3:149498884-149498884	skin	malignant_melanoma	Substitution - coding silent
c.174+3G>A; p.?; 3:149475054-149475054	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Unknown
c.401G>A; p.G134E; 3:149487755-149487755	skin	malignant_melanoma	Substitution - Missense
c.9T>G; p.T3T; 3:149474886-149474886	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.192G>T; p.L64L; 3:149475840-149475840	prostate	carcinoma	Substitution - coding silent
c.378A>G; p.T126T; 3:149487732-149487732	liver	carcinoma	Substitution - coding silent
c.53_54insT; p.G21fs*5; 3:149474930-149474931	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.415G>T; p.D139Y; 3:149498735-149498735	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.386A>G; p.Y129C; 3:149487740-149487740	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.181T>A; p.F61I; 3:149475829-149475829	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>T; p.S106L; 3:149487671-149487671	skin	malignant_melanoma	Substitution - Missense
c.128C>T; p.S43F; 3:149475005-149475005	skin	malignant_melanoma	Substitution - Missense
c.161G>A; p.G54E; 3:149475038-149475038	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.257G>A; p.R86Q; 3:149475905-149475905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.R86Q; 3:149475905-149475905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.257G>A; p.R86Q; 3:149475905-149475905	skin	malignant_melanoma	Substitution - Missense
c.36G>A; p.G12G; 3:149474913-149474913	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.595G>C; p.D199H; 3:149502679-149502679	urinary_tract; bladder	carcinoma	Substitution - Missense
c.30delG; p.T13fs*23; 3:149474907-149474907	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.30delG; p.T13fs*23; 3:149474907-149474907	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.220T>C; p.C74R; 3:149475868-149475868	skin	malignant_melanoma	Substitution - Missense
c.178A>G; p.I60V; 3:149475826-149475826	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.402G>A; p.G134G; 3:149498722-149498722	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.505A>G; p.I169V; 3:149498825-149498825	skin	malignant_melanoma	Substitution - Missense
c.338C>T; p.S113L; 3:149487692-149487692	urinary_tract; bladder	carcinoma	Substitution - Missense
c.278C>T; p.T93M; 3:149487632-149487632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>G; p.N25S; 3:149474951-149474951	skin	malignant_melanoma	Substitution - Missense
c.12G>A; p.G4G; 3:149474889-149474889	thyroid	other; neoplasm	Substitution - coding silent
c.12G>A; p.G4G; 3:149474889-149474889	thyroid	other; neoplasm	Substitution - coding silent
c.497T>C; p.V166A; 3:149498817-149498817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.54delT; p.F20fs*16; 3:149474931-149474931	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.54delT; p.F20fs*16; 3:149474931-149474931	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.54delT; p.F20fs*16; 3:149474931-149474931	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.541G>T; p.G181C; 3:149498861-149498861	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1A>G; p.M1V; 3:149474878-149474878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.C174C; 3:149498842-149498842	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.263C>T; p.A88V; 3:149475911-149475911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>T; p.A88V; 3:149475911-149475911	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.188C>T; p.A63V; 3:149475836-149475836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>T; p.G104*; 3:149487664-149487664	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.587delG; p.C196fs*>7; 3:149498907-149498907	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation