Cancer metastasis database

Annotation category 5

Gene information

Gene ID 7079
Symbol

TIMP4

Synonymous

-

Full name

TIMP metallopeptidase inhibitor 4

Gene description

TIMP-4|metalloproteinase inhibitor 4|tissue inhibitor of metalloproteinase 4|tissue inhibitor of metalloproteinases 4

Cytoband

3p25

Gene type

protein-coding

Synonymous

MIM:601915; HGNC:HGNC:11823; Ensembl:ENSG00000157150; HPRD:03557; Vega:OTTHUMG00000129763

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.501C>A; p.P167P; 3:12153689-12153689

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.357G>A; p.Q119Q; 3:12154447-12154447

 livercarcinomaSubstitution - coding silent

c.357G>A; p.Q119Q; 3:12154447-12154447

 livercarcinomaSubstitution - coding silent

c.265G>A; p.D89N; 3:12156907-12156907

 skinmalignant_melanomaSubstitution - Missense

c.606C>T; p.D202D; 3:12153584-12153584

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.449A>G; p.H150R; 3:12154355-12154355

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.193G>T; p.A65S; 3:12157429-12157429

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.604G>T; p.D202Y; 3:12153586-12153586

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.285G>A; p.T95T; 3:12156887-12156887

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.625C>T; p.R209W; 3:12153565-12153565

 central_nervous_system; braingliomaSubstitution - Missense

c.240G>C; p.M80I; 3:12156932-12156932

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.146G>A; p.R49Q; 3:12157476-12157476

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.411G>T; p.W137C; 3:12154393-12154393

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.17G>A; p.R6Q; 3:12158824-12158824

 pancreascarcinomaSubstitution - Missense

c.550G>T; p.E184*; 3:12153640-12153640

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.177G>A; p.P59P; 3:12157445-12157445

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.237+1G>A; p.?; 3:12157384-12157384

 skinmalignant_melanomaUnknown

c.214C>A; p.R72R; 3:12157408-12157408

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.517C>T; p.P173S; 3:12153673-12153673

 skinmalignant_melanomaSubstitution - Missense

c.549G>A; p.L183L; 3:12153641-12153641

 skinmalignant_melanomaSubstitution - coding silent

c.432G>A; p.Q144Q; 3:12154372-12154372

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - coding silent

c.414G>A; p.E138E; 3:12154390-12154390

 skinmalignant_melanomaSubstitution - coding silent

c.99C>T; p.A33A; 3:12158742-12158742

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.663C>T; p.I221I; 3:12153527-12153527

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.648G>A; p.K216K; 3:12153542-12153542

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.513G>T; p.S171S; 3:12153677-12153677

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.187G>T; p.D63Y; 3:12157435-12157435

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.177G>C; p.P59P; 3:12157445-12157445

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.76C>A; p.L26M; 3:12158765-12158765

 skin; earcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.215G>A; p.R72Q; 3:12157407-12157407

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.513G>A; p.S171S; 3:12153677-12153677

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.279C>G; p.I93M; 3:12156893-12156893

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.41T>C; p.L14S; 3:12158800-12158800

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.423C>T; p.S141S; 3:12154381-12154381

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.179C>A; p.A60D; 3:12157443-12157443

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.365G>T; p.S122I; 3:12154439-12154439

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.75_76insG; p.L26fs*3; 3:12158765-12158766

 bone; pelvisEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourInsertion - Frameshift

c.478-1G>A; p.?; 3:12153713-12153713

 lungcarcinoma; small_cell_carcinomaUnknown

c.413A>G; p.E138G; 3:12154391-12154391

 skinmalignant_melanomaSubstitution - Missense

c.100C>T; p.P34S; 3:12158741-12158741

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.420G>T; p.L140L; 3:12154384-12154384

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.512C>T; p.S171L; 3:12153678-12153678

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.57G>C; p.A19A; 3:12158784-12158784

 skinmalignant_melanomaSubstitution - coding silent

c.207A>C; p.K69N; 3:12157415-12157415

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.643A>G; p.R215G; 3:12153547-12153547

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.460C>T; p.L154L; 3:12154344-12154344

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.5C>T; p.P2L; 3:12158836-12158836

 stomachcarcinoma; adenocarcinomaSubstitution - Missense