lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7068
Symbol	THRB
Synonymous	C-ERBA-2\|C-ERBA-BETA\|ERBA2\|GRTH\|NR1A2\|PRTH\|THR1\|THRB1\|THRB2
Full name	thyroid hormone receptor, beta
Gene description	nuclear receptor subfamily 1 group A member 2\|oncogene ERBA2\|thyroid hormone nuclear receptor beta variant 1\|thyroid hormone receptor beta\|thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Cytoband	3p24.2
Gene type	protein-coding
Synonymous	MIM:190160; HGNC:HGNC:11799; Ensembl:ENSG00000151090; HPRD:07521; Vega:OTTHUMG00000130478

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.431C>T; p.S144F; 3:24146776-24146776	skin	malignant_melanoma	Substitution - Missense
c.955G>A; p.V319M; 3:24127688-24127688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.649G>A; p.E217K; 3:24143590-24143590	skin	malignant_melanoma	Substitution - Missense
c.172C>T; p.L58F; 3:24190185-24190185	skin	malignant_melanoma	Substitution - Missense
c.469A>T; p.T157S; 3:24146738-24146738	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.341C>G; p.A114G; 3:24152433-24152433	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.157C>T; p.Q53*; 3:24190200-24190200	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1354C>T; p.P452S; 3:24122916-24122916	skin	malignant_melanoma	Substitution - Missense
c.368C>T; p.T123M; 3:24152406-24152406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1358C>T; p.P453L; 3:24122912-24122912	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.400A>G; p.T134A; 3:24146807-24146807	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.E220K; 3:24143581-24143581	skin	malignant_melanoma	Substitution - Missense
c.144G>A; p.T48T; 3:24190213-24190213	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.164C>T; p.S55L; 3:24190193-24190193	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.164C>T; p.S55L; 3:24190193-24190193	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.144G>A; p.T48T; 3:24190213-24190213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.144G>A; p.T48T; 3:24190213-24190213	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.205C>T; p.H69Y; 3:24190152-24190152	skin	malignant_melanoma	Substitution - Missense
c.639G>A; p.E213E; 3:24143600-24143600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.497T>A; p.F166Y; 3:24146710-24146710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1307C>A; p.A436D; 3:24122963-24122963	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1312C>G; p.R438G; 3:24122958-24122958	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1381G>T; p.D461Y; 3:24122889-24122889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.417C>T; p.L139L; 3:24146790-24146790	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1205C>T; p.A402V; 3:24123065-24123065	skin	malignant_melanoma	Substitution - Missense
c.401C>T; p.T134I; 3:24146806-24146806	skin	malignant_melanoma	Substitution - Missense
c.571C>G; p.L191V; 3:24143668-24143668	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1377C>T; p.F459F; 3:24122893-24122893	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.159G>A; p.Q53Q; 3:24190198-24190198	skin	malignant_melanoma	Substitution - coding silent
c.123C>T; p.S41S; 3:24190234-24190234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1377C>T; p.F459F; 3:24122893-24122893	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.425C>T; p.S142F; 3:24146782-24146782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.37G>A; p.A13T; 3:24190320-24190320	skin	malignant_melanoma	Substitution - Missense
c.76G>A; p.D26N; 3:24190281-24190281	skin	malignant_melanoma	Substitution - Missense
c.727C>T; p.R243W; 3:24143512-24143512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.76G>A; p.D26N; 3:24190281-24190281	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.949G>A; p.A317T; 3:24127694-24127694	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.P141S; 3:24146786-24146786	skin	malignant_melanoma	Substitution - Missense
c.723A>G; p.Q241Q; 3:24143516-24143516	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.560C>T; p.A187V; 3:24143679-24143679	skin	malignant_melanoma	Substitution - Missense
c.721C>A; p.Q241K; 3:24143518-24143518	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.373G>A; p.E125K; 3:24152401-24152401	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1299C>T; p.A433A; 3:24122971-24122971	skin	malignant_melanoma	Substitution - coding silent
c.701C>T; p.A234V; 3:24143538-24143538	skin	malignant_melanoma	Substitution - Missense
c.940T>C; p.S314P; 3:24127703-24127703	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>T; p.E163*; 3:24146720-24146720	skin	malignant_melanoma	Substitution - Nonsense
c.70G>C; p.E24Q; 3:24190287-24190287	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.148A>T; p.K50*; 3:24190209-24190209	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1056C>A; p.A352A; 3:24127587-24127587	thyroid	other; neoplasm	Substitution - coding silent
c.607G>A; p.E203K; 3:24143632-24143632	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.607G>A; p.E203K; 3:24143632-24143632	skin	malignant_melanoma	Substitution - Missense
c.493C>T; p.R165C; 3:24146714-24146714	prostate	carcinoma	Substitution - Missense
c.1348C>A; p.L450I; 3:24122922-24122922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.995G>A; p.G332E; 3:24127648-24127648	skin	malignant_melanoma	Substitution - Missense
c.312C>T; p.D104D; 3:24152462-24152462	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1286G>A; p.R429Q; 3:24122984-24122984	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.700G>A; p.A234T; 3:24143539-24143539	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.577G>A; p.E193K; 3:24143662-24143662	liver	carcinoma	Substitution - Missense
c.577G>A; p.E193K; 3:24143662-24143662	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.529G>A; p.D177N; 3:24146678-24146678	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1148G>A; p.R383H; 3:24123122-24123122	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.162G>T; p.S54S; 3:24190195-24190195	pancreas	carcinoma	Substitution - coding silent
c.473G>A; p.R158Q; 3:24146734-24146734	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.473G>A; p.R158Q; 3:24146734-24146734	skin	malignant_melanoma	Substitution - Missense
c.473G>A; p.R158Q; 3:24146734-24146734	skin; mucosal	malignant_melanoma	Substitution - Missense
c.679G>A; p.E227K; 3:24143560-24143560	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1013G>A; p.R338Q; 3:24127630-24127630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.119A>G; p.K40R; 3:24190238-24190238	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.567G>A; p.R189R; 3:24143672-24143672	skin	malignant_melanoma	Substitution - coding silent
c.158A>G; p.Q53R; 3:24190199-24190199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1286G>T; p.R429L; 3:24122984-24122984	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.664A>G; p.I222V; 3:24143575-24143575	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.167C>T; p.P56L; 3:24190190-24190190	skin	malignant_melanoma	Substitution - Missense
c.169C>T; p.H57Y; 3:24190188-24190188	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.666C>G; p.I222M; 3:24143573-24143573	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.78C>T; p.D26D; 3:24190279-24190279	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.657G>A; p.W219*; 3:24143582-24143582	skin	malignant_melanoma	Substitution - Nonsense
c.597A>G; p.R199R; 3:24143642-24143642	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.596G>A; p.R199K; 3:24143643-24143643	skin	malignant_melanoma	Substitution - Missense
c.864A>G; p.K288K; 3:24133337-24133337	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.722A>G; p.Q241R; 3:24143517-24143517	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.34A>G; p.T12A; 3:24190323-24190323	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.402C>T; p.T134T; 3:24146805-24146805	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.402C>T; p.T134T; 3:24146805-24146805	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75C>T; p.H25H; 3:24190282-24190282	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1078C>A; p.L360M; 3:24127565-24127565	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.97T>C; p.S33P; 3:24190260-24190260	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1177G>A; p.E393K; 3:24123093-24123093	skin	malignant_melanoma	Substitution - Missense
c.1273G>A; p.V425M; 3:24122997-24122997	oesophagus	carcinoma	Substitution - Missense
c.331G>T; p.G111C; 3:24152443-24152443	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1059C>A; p.I353I; 3:24127584-24127584	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.648C>T; p.D216D; 3:24143591-24143591	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.648C>T; p.D216D; 3:24143591-24143591	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1371A>C; p.E457D; 3:24122899-24122899	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1367T>C; p.L456S; 3:24122903-24122903	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1371A>C; p.E457D; 3:24122899-24122899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1023G>A; p.L341L; 3:24127620-24127620	skin	malignant_melanoma	Substitution - coding silent
c.143C>T; p.T48M; 3:24190214-24190214	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.143C>T; p.T48M; 3:24190214-24190214	pancreas	carcinoma	Substitution - Missense
c.1023G>A; p.L341L; 3:24127620-24127620	skin	malignant_melanoma	Substitution - coding silent
c.1023G>A; p.L341L; 3:24127620-24127620	skin	malignant_melanoma	Substitution - coding silent
c.586C>T; p.R196W; 3:24143653-24143653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.8C>T; p.P3L; 3:24228952-24228952	skin	malignant_melanoma	Substitution - Missense
c.175A>C; p.I59L; 3:24190182-24190182	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1012C>T; p.R338W; 3:24127631-24127631	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.870G>A; p.L290L; 3:24133331-24133331	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.692C>T; p.A231V; 3:24143547-24143547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.693G>A; p.A231A; 3:24143546-24143546	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1217A>G; p.Y406C; 3:24123053-24123053	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.653A>G; p.E218G; 3:24143586-24143586	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.174C>T; p.L58L; 3:24190183-24190183	skin	malignant_melanoma	Substitution - coding silent
c.1055C>T; p.A352V; 3:24127588-24127588	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1099G>A; p.D367N; 3:24127544-24127544	breast	carcinoma	Substitution - Missense
c.624C>T; p.I208I; 3:24143615-24143615	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.540G>A; p.L180L; 3:24143699-24143699	skin	malignant_melanoma	Substitution - coding silent
c.87A>C; p.L29L; 3:24190270-24190270	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation