lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7019
Symbol	TFAM
Synonymous	MTTF1\|MTTFA\|TCF6\|TCF6L1\|TCF6L2\|TCF6L3
Full name	transcription factor A, mitochondrial
Gene description	mitochondrial transcription factor 1\|mitochondrial transcription factor A\|transcription factor 6\|transcription factor 6-like 1\|transcription factor 6-like 2 (mitochondrial transcription factor)\|transcription factor 6-like 3
Cytoband	10q21
Gene type	protein-coding
Synonymous	MIM:600438; HGNC:HGNC:11741; Ensembl:ENSG00000108064; HPRD:02702; Vega:OTTHUMG00000018270

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.221-1G>A; p.?; 10:58388189-58388189	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.517G>T; p.A173S; 10:58390840-58390840	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.703A>G; p.I235V; 10:58395036-58395036	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.221-2A>G; p.?; 10:58388188-58388188	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.517G>A; p.A173T; 10:58390840-58390840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.666G>T; p.M222I; 10:58394999-58394999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.314C>T; p.A105V; 10:58388692-58388692	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.621C>T; p.D207D; 10:58394954-58394954	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>T; p.M215I; 10:58394978-58394978	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.441+2T>G; p.?; 10:58388821-58388821	urinary_tract; bladder	carcinoma	Unknown
c.117G>A; p.P39P; 10:58386235-58386235	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	breast	carcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.432delA; p.E148fs*2; 10:58388810-58388810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.375G>A; p.Q125Q; 10:58388753-58388753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.104T>G; p.F35C; 10:58386222-58386222	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.698G>A; p.R233H; 10:58395031-58395031	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.97T>C; p.F33L; 10:58385644-58385644	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.506G>T; p.R169I; 10:58390829-58390829	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>A; p.L182L; 10:58394366-58394366	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.546G>A; p.L182L; 10:58394366-58394366	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.274C>T; p.P92S; 10:58388243-58388243	liver	carcinoma	Substitution - Missense
c.337G>C; p.E113Q; 10:58388715-58388715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595T>C; p.L199L; 10:58394928-58394928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.160G>T; p.V54L; 10:58386278-58386278	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>A; p.D207N; 10:58394952-58394952	skin	malignant_melanoma	Substitution - Missense
c.694C>T; p.R232C; 10:58395027-58395027	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472C>A; p.P158T; 10:58390795-58390795	thyroid	other; neoplasm	Substitution - Missense
c.388G>A; p.E130K; 10:58388766-58388766	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.185A>T; p.K62I; 10:58386303-58386303	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.82C>T; p.R28*; 10:58385629-58385629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.629G>A; p.R210H; 10:58394962-58394962	pancreas	carcinoma	Substitution - Missense
c.715C>T; p.R239*; 10:58395048-58395048	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Nonsense
c.475C>T; p.R159C; 10:58390798-58390798	skin	malignant_melanoma	Substitution - Missense
c.429G>A; p.M143I; 10:58388807-58388807	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.432_433delAA; p.K147fs*16; 10:58388810-58388811	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.153G>T; p.K51N; 10:58386271-58386271	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.341T>G; p.I114R; 10:58388719-58388719	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.25G>C; p.G9R; 10:58385572-58385572	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation