lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6934
Symbol	TCF7L2
Synonymous	TCF-4\|TCF4
Full name	transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene description	HMG box transcription factor 4\|T-cell factor 4\|T-cell factor-4 variant A\|T-cell factor-4 variant B\|T-cell factor-4 variant C\|T-cell factor-4 variant D\|T-cell factor-4 variant E\|T-cell factor-4 variant F\|T-cell factor-4 variant G\|T-cell factor-4 variant H\|
Cytoband	10q25.3
Gene type	protein-coding
Synonymous	MIM:602228; HGNC:HGNC:11641; Ensembl:ENSG00000148737; HPRD:03751; Vega:OTTHUMG00000019070

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1465C>G; p.P489A; 10:113165646-113165646	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1035C>A; p.V345V; 10:113151827-113151827	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.866C>T; p.P289L; 10:113151057-113151057	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.932+1G>A; p.?; 10:113151124-113151124	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.546G>C; p.T182T; 10:113141246-113141246	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.332T>C; p.L111P; 10:112951558-112951558	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1458G>A; p.S486S; 10:113165639-113165639	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.187G>A; p.E63K; 10:112950943-112950943	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.80_82delAGG; p.E29delE; 10:112950836-112950838	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1185C>A; p.S395S; 10:113152425-113152425	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.916G>A; p.G306S; 10:113151107-113151107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1472C>T; p.P491L; 10:113165653-113165653	skin	malignant_melanoma	Substitution - Missense
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - coding silent
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - coding silent
c.49G>T; p.E17*; 10:112950805-112950805	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1393C>T; p.R465C; 10:113165574-113165574	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>T; p.G252*; 10:113146045-113146045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.590_591insA; p.P198fs*107; 10:113141290-113141291	large_intestine	NS	Insertion - Frameshift
c.1393C>A; p.R465S; 10:113165574-113165574	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153Q; 10:113040101-113040101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>A; p.R363R; 10:113151879-113151879	thyroid	carcinoma	Substitution - coding silent
c.503T>C; p.V168A; 10:113141203-113141203	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1289C>T; p.P430L; 10:113158706-113158706	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1488C>T; p.S496S; 10:113165669-113165669	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1488C>T; p.S496S; 10:113165669-113165669	skin	malignant_melanoma	Substitution - coding silent
c.439C>T; p.Q147*; 10:113040082-113040082	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1606G>A; p.E536K; 10:113165787-113165787	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1063G>A; p.A355T; 10:113151855-113151855	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.381+1G>A; p.?; 10:112951608-112951608	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1288C>T; p.P430S; 10:113158705-113158705	breast	carcinoma	Substitution - Missense
c.439C>T; p.Q147*; 10:113040082-113040082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.818_834del17; p.H273fs*26; 10:113151009-113151025	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.698C>T; p.P233L; 10:113144004-113144004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.835C>T; p.H279Y; 10:113151026-113151026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1462C>T; p.P488S; 10:113165643-113165643	skin	malignant_melanoma	Substitution - Missense
c.1187C>T; p.A396V; 10:113152427-113152427	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1187C>T; p.A396V; 10:113152427-113152427	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1186G>A; p.A396T; 10:113152426-113152426	breast	carcinoma	Substitution - Missense
c.740C>T; p.P247L; 10:113146031-113146031	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>A; p.S46*; 10:112950893-112950893	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1131C>T; p.Y377Y; 10:113152371-113152371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.994A>G; p.N332D; 10:113151786-113151786	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152A>G; p.E51G; 10:112950908-112950908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.904C>T; p.Q302*; 10:113151095-113151095	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.303C>A; p.P101P; 10:112951529-112951529	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1204_1206delAAG; p.K405delK; 10:113158024-113158026	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.932_932+1insGT; p.K312fs*1; 10:113151123-113151124	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1471C>T; p.P491S; 10:113165652-113165652	skin	malignant_melanoma	Substitution - Missense
c.1738C>G; p.L580V; 10:113165919-113165919	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1738C>G; p.L580V; 10:113165919-113165919	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.P431L; 10:113158709-113158709	skin	malignant_melanoma	Substitution - Missense
c.140C>T; p.S47F; 10:112950896-112950896	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>T; p.P208S; 10:113143928-113143928	skin	malignant_melanoma	Substitution - Missense
c.1000delT; p.F334fs*5; 10:113151792-113151792	skin; trunk	malignant_melanoma	Deletion - Frameshift
c.398G>A; p.W133*; 10:113040041-113040041	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.398G>A; p.W133*; 10:113040041-113040041	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.622C>A; p.P208T; 10:113143928-113143928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>T; p.R153L; 10:113040101-113040101	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.218A>C; p.E73A; 10:112951235-112951235	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.461C>A; p.S154Y; 10:113040104-113040104	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1201-2A>G; p.?; 10:113158019-113158019	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.860C>T; p.P287L; 10:113151051-113151051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.774C>A; p.P258P; 10:113146065-113146065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002C>A; p.F334L; 10:113151794-113151794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1362C>T; p.C454C; 10:113159981-113159981	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1002C>A; p.F334L; 10:113151794-113151794	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1002C>A; p.F334L; 10:113151794-113151794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1025G>T; p.R342I; 10:113151817-113151817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200+2T>C; p.?; 10:113152442-113152442	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1766C>T; p.S589L; 10:113165947-113165947	liver	carcinoma	Substitution - Missense
c.1468T>C; p.S490P; 10:113165649-113165649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1741G>T; p.A581S; 10:113165922-113165922	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469C>T; p.P157S; 10:113040112-113040112	skin	malignant_melanoma	Substitution - Missense
c.657T>G; p.Y219*; 10:113143963-113143963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1240G>T; p.E414*; 10:113158060-113158060	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.1081C>T; p.L361F; 10:113151873-113151873	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.746C>T; p.T249M; 10:113146037-113146037	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1473G>A; p.P491P; 10:113165654-113165654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.416delA; p.Q139fs*63; 10:113040059-113040059	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1457C>T; p.S486L; 10:113165638-113165638	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.76G>C; p.E26Q; 10:112950832-112950832	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.616G>A; p.G206R; 10:113141316-113141316	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.616G>A; p.G206R; 10:113141316-113141316	large_intestine; caecum	adenoma	Substitution - Missense
c.1068C>A; p.A356A; 10:113151860-113151860	ovary	other; neoplasm	Substitution - coding silent
c.932C>T; p.S311L; 10:113151123-113151123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1163_1164insT; p.M388fs*12; 10:113152403-113152404	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1552G>A; p.D518N; 10:113165733-113165733	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1163_1164insT; p.M388fs*12; 10:113152403-113152404	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1552G>A; p.D518N; 10:113165733-113165733	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1767G>A; p.S589S; 10:113165948-113165948	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329G>A; p.A443A; 10:113159948-113159948	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1680C>T; p.A560A; 10:113165861-113165861	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1157T>G; p.L386R; 10:113152397-113152397	central_nervous_system; brain	glioma	Substitution - Missense
c.1330C>T; p.R444C; 10:113159949-113159949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747G>A; p.T249T; 10:113146038-113146038	skin	malignant_melanoma	Substitution - coding silent
c.1379_1400del22; p.K460fs*18; 10:113165560-113165581	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.888C>T; p.V296V; 10:113151079-113151079	large_intestine; rectum	adenoma	Substitution - coding silent
c.1379_1400del22; p.K460fs*18; 10:113165560-113165581	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.690delC; p.H232fs*3; 10:113143996-113143996	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1093-2A>T; p.?; 10:113152331-113152331	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.566C>T; p.T189M; 10:113141266-113141266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1775C>A; p.T592N; 10:113165956-113165956	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.699G>A; p.P233P; 10:113144005-113144005	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1009T>C; p.Y337H; 10:113151801-113151801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.P289S; 10:113151056-113151056	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1159C>A; p.H387N; 10:113152399-113152399	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1159C>A; p.H387N; 10:113152399-113152399	liver	carcinoma	Substitution - Missense
c.70G>T; p.E24*; 10:112950826-112950826	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1584G>A; p.P528P; 10:113165765-113165765	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.P498P; 10:113165675-113165675	skin	malignant_melanoma	Substitution - coding silent
c.1584G>A; p.P528P; 10:113165765-113165765	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.221G>C; p.S74T; 10:112951238-112951238	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.542T>C; p.I181T; 10:113141242-113141242	central_nervous_system; brainstem	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1465C>T; p.P489S; 10:113165646-113165646	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1176C>T; p.P392P; 10:113152416-113152416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1388G>A; p.C463Y; 10:113165569-113165569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1293G>A; p.P431P; 10:113158710-113158710	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1192G>T; p.D398Y; 10:113152432-113152432	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.525delC; p.L177fs*25; 10:113141225-113141225	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.772C>A; p.P258T; 10:113146063-113146063	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.772C>A; p.P258T; 10:113146063-113146063	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.525delC; p.L177fs*25; 10:113141225-113141225	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1121C>T; p.A374V; 10:113152361-113152361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1122G>A; p.A374A; 10:113152362-113152362	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1121C>T; p.A374V; 10:113152361-113152361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>A; p.V201I; 10:113141301-113141301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.862C>T; p.H288Y; 10:113151053-113151053	breast	carcinoma	Substitution - Missense
c.1158T>C; p.L386L; 10:113152398-113152398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1189C>T; p.R397W; 10:113152429-113152429	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1189C>T; p.R397W; 10:113152429-113152429	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.604G>T; p.D202Y; 10:113141304-113141304	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1013T>G; p.M338R; 10:113151805-113151805	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.26G>A; p.G9E; 10:112950782-112950782	skin	malignant_melanoma	Substitution - Missense
c.1338C>T; p.G446G; 10:113159957-113159957	liver	carcinoma	Substitution - coding silent
c.840G>A; p.T280T; 10:113151031-113151031	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.598G>A; p.D200N; 10:113141298-113141298	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.771C>A; p.Y257*; 10:113146062-113146062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1201-1G>C; p.?; 10:113158020-113158020	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.771C>A; p.Y257*; 10:113146062-113146062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1755C>T; p.P585P; 10:113165936-113165936	skin	malignant_melanoma	Substitution - coding silent
c.1536G>A; p.S512S; 10:113165717-113165717	large_intestine; colon	NS	Substitution - coding silent
c.1556C>T; p.P519L; 10:113165737-113165737	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.238C>A; p.R80R; 10:112951255-112951255	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.584C>T; p.P195L; 10:113141284-113141284	skin	malignant_melanoma	Substitution - Missense
c.1626C>T; p.S542S; 10:113165807-113165807	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1694C>T; p.S565L; 10:113165875-113165875	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.692C>T; p.P231L; 10:113143998-113143998	skin	malignant_melanoma	Substitution - Missense
c.143T>C; p.L48P; 10:112950899-112950899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1389C>T; p.C463C; 10:113165570-113165570	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.551_552GC>TT; p.S184>?; 10:113141251-113141252	large_intestine; rectum	carcinoma; adenocarcinoma	Complex
c.1077G>T; p.Q359H; 10:113151869-113151869	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545C>T; p.T182M; 10:113141245-113141245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1132G>T; p.E378*; 10:113152372-113152372	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Nonsense
c.1132G>T; p.E378*; 10:113152372-113152372	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1191G>T; p.R397R; 10:113152431-113152431	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.505C>T; p.Q169*; 10:113141205-113141205	liver	carcinoma	Substitution - Nonsense
c.1692A>G; p.S564S; 10:113165873-113165873	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.505C>T; p.Q169*; 10:113141205-113141205	liver	carcinoma	Substitution - Nonsense
c.1401A>G; p.I467M; 10:113165582-113165582	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1682C>T; p.A561V; 10:113165863-113165863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.A87T; 10:112951485-112951485	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.259G>A; p.A87T; 10:112951485-112951485	urinary_tract; bladder	carcinoma	Substitution - Missense
c.534G>A; p.T178T; 10:113141234-113141234	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140C>T; p.A380A; 10:113152380-113152380	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.1140C>T; p.A380A; 10:113152380-113152380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1430C>T; p.P477L; 10:113165611-113165611	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>T; p.S354S; 10:113151854-113151854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.556G>T; p.E186*; 10:113141256-113141256	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1561G>A; p.A521T; 10:113165742-113165742	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1378A>C; p.K460Q; 10:113165559-113165559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.915C>T; p.V305V; 10:113151106-113151106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.915C>T; p.V305V; 10:113151106-113151106	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.774C>T; p.P258P; 10:113146065-113146065	skin	malignant_melanoma	Substitution - coding silent
c.567G>A; p.T189T; 10:113141267-113141267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1505A>G; p.K502R; 10:113165686-113165686	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1703A>G; p.Q568R; 10:113165884-113165884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1375_1376insG; p.C463fs*8; 10:113165556-113165557	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1182G>T; p.W394C; 10:113152422-113152422	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation